Conjunctival Tophi Associated With Gout

Yourish, Norman

doi:10.1001/archopht.1953.00920030377022

Cited by 15 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Crystalline deposits have been identified in the conjunctiva, sclera, and cornea. 5,6 Other ocular conditions associated with gout are scleritis, episcleritis, uveitis, asteroid hyalosis, increased intraocular pressure, and chronically hyperemic conjunctivae. 7 However, after studying 69 patients with gout, Ferry et al 7 concluded that gout had been overemphasized as a cause of uveitis.…”

Section: Report Of a Casementioning

confidence: 99%

“…Yourish's case report described a "conjunctival tophus associated with gout," but no histopathological examination was performed. 5 The crystals he described in and beneath the conjunctiva were identified as a urate salt by chemical reaction. Martinez-Cordero et al 6 observed a scleral "tophus," but no inflammation was described, and no histopathological study was recorded.…”

Section: Report Of a Casementioning

confidence: 99%

See 1 more Smart Citation

Pyogenic Granuloma of the Cornea in an Infant With Unilateral Microphthalmia

Karatza

Calhoun²,

Eagle³

2003

Arch Ophthalmol

View full text Add to dashboard Cite

Section: Report Of a Casementioning

confidence: 99%

Section: Report Of a Casementioning

confidence: 99%

Pyogenic Granuloma of the Cornea in an Infant With Unilateral Microphthalmia

Karatza

Calhoun²,

Eagle³

2003

Arch Ophthalmol

View full text Add to dashboard Cite

“…Nursing home residents have experienced the brunt of the coronavirus disease 2019 (COVID-19) epidemic. Recent estimates suggest that nursing home residents comprise approximately 35% of COVID-19 deaths in the US and between 66% and 81% of deaths in Canada . Compared with community-dwelling older adults, nursing home residents are 5 times more likely to die of COVID-19 .…”

Section: Introductionmentioning

confidence: 99%

Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada

et al. 2021

View full text Add to dashboard Cite

IMPORTANCE Nursing home residents have been disproportionately affected by coronavirus disease 2019 . Prevention recommendations emphasize frequent testing of health care personnel and residents, but additional strategies are needed.OBJECTIVE To develop a reproducible index of nursing home crowding and determine whether crowding was associated with COVID-19 cases and mortality in the first months of the COVID-19 epidemic.DESIGN, SETTING, AND PARTICIPANTS This population-based retrospective cohort study included more than 78 000 residents across more than 600 nursing homes in Ontario, Canada, and was conducted from March 29 to May 20, 2020.EXPOSURES The nursing home crowding index equaled the mean number of residents per bedroom and bathroom. MAIN OUTCOMES AND MEASURESThe cumulative incidence of COVID-19 cases confirmed by a validated nucleic acid amplification assay and mortality per 100 residents; the introduction of COVID-19 into a home (Ն1 resident case) was a negative tracer. RESULTSOf 623 homes in Ontario, we obtained complete information on 618 homes (99%) housing 78 607 residents (women, 54 160 [68.9%]; age Ն85 years, 42 919 [54.6%]). A total of 5218 residents (6.6%) developed COVID-19 infection, and 1452 (1.8%) died of COVID-19 infection as of May 20, 2020. COVID-19 infection was distributed unevenly across nursing homes; 4496 infections (86%) occurred in 63 homes (10%). The crowding index ranged across homes from 1.3 (mainly single-occupancy rooms) to 4.0 (exclusively quadruple occupancy rooms); 308 homes (50%) had a high crowding index (Ն2). Incidence in high crowding index homes was 9.7% vs 4.5% in low crowding index homes (P < .001), while COVID-19 mortality was 2.7% vs 1.3%, respectively (P < .001). The likelihood of COVID-19 introduction did not differ (high = 31.3% vs low = 30.2%; P = .79). After adjustment for regional, nursing home, and resident covariates, the crowding index remained associated with an increased incidence of infection (relative risk [RR] = 1.73, 95% CI, 1.10-2.72) and mortality (RR, 1.69; 95% CI, 0.99-2.87). A propensity score analysis yielded similar conclusions for infection (RR, 2.09; 95% CI, 1.30-3.38) and mortality (RR, 1.83; 95% CI, 1.09-3.08). Simulations suggested that converting all 4-bed rooms to 2-bed rooms would have averted 998 COVID-19 cases (19.1%) and 263 deaths (18.1%). CONCLUSIONS AND RELEVANCEIn this cohort of Canadian nursing homes, crowding was common and crowded homes were more likely to experience larger and deadlier COVID-19 outbreaks.

show abstract

“…Precipitation of urate crystal has been described in eyelids, tarsal plates, conjunctiva, cornea, sclera, tendons of extraocular muscles, orbit, and lens. It has been reported that tophi can be deposited in the iris or in the anterior chamber, causing anterior uveitis or glaucoma [43]. Lin et al [42], found uric acid crystals on the ocular surface in 3/380 (0.79%) consecutive gout patients.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Monosodium Urate (MSU) Deposits in Cadavers Detected by Dual-Energy Computed Tomography (DECT)

et al. 2022

View full text Add to dashboard Cite

Background: Dual-energy computed tomography (DECT) allows direct visualization of monosodium urate (MSU) deposits in joints and soft tissues. Purpose: To describe the distribution of MSU deposits in cadavers using DECT in the head, body trunk, and feet. Materials and Methods: A total of 49 cadavers (41 embalmed and 8 fresh cadavers; 20 male, 29 female; mean age, 79.5 years; SD ± 11.3; range 52–95) of unknown clinical history underwent DECT to assess MSU deposits in the head, body trunk, and feet. Lens, thoracic aorta, and foot tendon dissections of fresh cadavers were used to verify MSU deposits by polarizing light microscopy. Results: 33/41 embalmed cadavers (80.5%) showed MSU deposits within the thoracic aorta. 11/41 cadavers (26.8%) showed MSU deposits within the metatarsophalangeal (MTP) joints and 46.3% of cadavers demonstrated MSU deposits within foot tendons, larger than and equal to 5 mm. No MSU deposits were detected in the cranium/intracerebral vessels, or the coronary arteries. Microscopy used as a gold standard could verify the presence of MSU deposits within the lens, thoracic aorta, or foot tendons in eight fresh cadavers. Conclusions: Microscopy confirmed the presence of MSU deposits in fresh cadavers within the lens, thoracic aorta, and foot tendons, whereas no MSU deposits could be detected in cranium/intracerebral vessels or coronary arteries. DECT may offer great potential as a screening tool to detect MSU deposits and measure the total uric acid burden in the body. The clinical impact of this cadaver study in terms of assessment of MSU burden should be further proven.

show abstract

Conjunctival Tophi Associated With Gout

Cited by 15 publications

References 6 publications

Pyogenic Granuloma of the Cornea in an Infant With Unilateral Microphthalmia

Pyogenic Granuloma of the Cornea in an Infant With Unilateral Microphthalmia

Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada

Prevalence of Monosodium Urate (MSU) Deposits in Cadavers Detected by Dual-Energy Computed Tomography (DECT)

Contact Info

Product

Resources

About