Conjunctival tumors in children: histopathologic diagnosis in 165 cases

Abstract

(3-6).Cunha et al. reported the histopathology of 282 consecutive, clinically diagnosed epibulbar tumors excised from children. The most common tumors were melanocytic (23%), choristomatous (22%), and benign epithelial (10%) tumors (3) . In another case series, Elsas et al. reported 302 cases of epibulbar tumors in children, comprising 33% choristomas, 29% conjunctival nevi, 11% epithelial inclusion cysts, 7% papillomas, 6% pyogenic granulomas, and 5% granulomas (4) . Beby et ABSTRACT Purpose: Conjunctival tissue tumors have a varied presentation, and few series studies on pediatric patients have been published. The objective of this paper is to report the histopathologic diagnoses (spanning over 1988-2013) of conjunctival tumors in children younger than 14 years. Methods: We conducted a retrospective, descriptive, and observational study by reviewing the database of all children in whom a conjunctival tumor was surgically removed at Hospital de Ojos y Oídos "Dr. Rodolfo Robles V., " Benemérito Comité Pro Ciegos y Sordos de Guatemala. The data pertaining to gender, age, and histopathologic diagnosis of all cases was collected. The same ocular pathologist made all diagnoses. Results: One hundred sixty-five cases were found, with a mean age of 7.88 years, being 91 (55.15%) male subjects. Melanocytic lesions were the most common tumors found (30.91% of cases), with only one case (0.60%) being malignant. Conclusions: Melanocytic lesions were the most common tumors found, and of all the cases, only one was malignant; this was in a patient with xeroderma pigmentosum. These findings are consistent with those reported in other studies regarding the frequencies of the histopathology of conjunctival tumors in the pediatric population.

Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians

“…Primary ocular surface tumors (OSTs) are diverse and include degenerative, inflammatory lesions, choristomas/hamartomas, benign and malignant epithelial lesions, melanocytic, hematolymphoid, and soft tissue tumors [1, 2]. Most of these lesions have overlapping clinical features that make a distinction on clinical examination alone a challenge [3].…”

Benigne und maligne Bindehauttumoren in Diagnostik und Therapie

“…Konjunktivale Papillome sind Tumoren, die sowohl im Kindes-als auch im Erwachsenenalter auftreten (Altershöhepunkt 20-40 Jahre) und vom Plattenepithel abstammen (Übersicht bei [6]). Sie stellen zwischen 1 und 12 % der konjunktivalen Tumoren dar [2,7]. Ein Zusammenhang zu einer HPV-Infektion (humanes Papillomavirus), insbesondere mit den Low-Risk-Serotypen 6 und 11, wurde in verschiedenen Studien hergestellt [8].…”

Overview and Classification of Conjunctival and Corneal Tumors

“…Shields et al described 1643 conjunctival lesions, among which 872 (53%) were melanocytic tumors, including nevus, primary acquired melanosis, and melanoma [5]. Even in the pediatric population, melanocytic tumors are the most common tumor in a clinical practice as Shields et al reviewed 262 children and noted the leading tumors included melanocytic (67%), choristomatous (10%), vascular (9%), and benign epithelial tumors (2%), as well as other miscellaneous lesions (10%) [6,7].…”

“…The conjunctival melanocytic tumors include nevus, racial melanosis, primary acquired melanosis, and melanoma. Conjunctival nevus is the most common tumor in both children and adults [5][6][7]16]. In a large clinical review of 5002 cases, nevus accounted for 45% (n = 1163/2590) of conjunctival melanocytic lesions and for 23% of all 5002 conjunctival lesions [8].…”

“…Vascular, neural, fibrous, lipomatous, xanthomatous, metastatic, and secondary tumors of the conjunctiva are rare and together comprise approximately 10% of all conjunctival tumors [5]. For more information on those tumors, reference to major articles [1,[4][5][6][7][8][9] and textbooks [10,17,[24][25][26][27] is advised.…”