Aim of the study. -The lack of traceability and monitoring of blood donors and transfused patients constitute a barrier to the most basic rules of haemovigilance and overall good transfusion practices. This study draws up an inventory of knowledge, attitudes and clinical practice of blood prescribers in Niamey. Materials and methods. -A questionnaire was administered to 180 prescribers of blood products in Niamey in 2011. Questions were related to basic informations on blood transfusion and clinical use of blood. Analyses were performed using SAS 9.3 version.Results. -The sample consisted of 180 respondents from several professional categories: 51 physicians (28.33%), 10 medical students (5.56%), 84 nurses (46.67%), 15 anaesthesiologist assistant (8.33%) and 20 midwives (11.11%). Among these, 22.2% received training in blood transfusion safety. Half of the respondents (50.8%) got between 50 and 75% of correct answers, 45.8% got less than 50% correct while 3.35% scored more than 75% correct answers. The overall quality of responses was higher among physicians compared to other prescribers (P < 0.0001); among respondents who received training in transfusion safety (P < 0.0001); and among males (P = 0.0306). For some items, subjects with more experience scored the best. Conclusion. -The level of knowledge is still inadequate. More training in transfusion practices is necessary for prescribers of blood products. Accompanying measures to improve transfusion practice must be considered or strengthened through assessments, knowledge update/upgrade (regular, ongoing training) and establishment of active and motivated hospital transfusion committees. © 2015 Elsevier Masson SAS. All rights reserved. Z. Mayaki et al. / Transfusion Clinique et Biologique 23 (2016) 78-85 79 Conclusion. -Le niveau des connaissances étant insuffisant, des formations en transfusion sont nécessaires pour les prescripteurs de produits sanguins. Des mesures d'accompagnement devraient être envisagées ou renforcées au moyen d'évaluations, de remises à niveau (formation continue), et par la mise en place de comités hospitaliers de transfusion actifs et motivés.