Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

Seifer, David B.

doi:10.1016/j.fertnstert.2021.01.020

Cited by 4 publications

(4 citation statements)

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“…As maternal age was identified as a prominent confounding factor affecting AMH levels and AFC, we further compared the PM0 and PM3 groups after stratification by age (Table 3). Among participants aged <35 years, AMH and AFC levels were both significantly higher in the PM0 group (median 4.96 ng/ml, IQR [2.99-8.00] and median 11 number, IQR [8][9][10][11][12][13][14][15], respectively) than in the PM3 group (median 3.62 ng/ml, IQR [1.71-5.49], P =…”

Section: The Relationship Between the Pm0 And Pm3 Groups And Ormentioning

confidence: 99%

“…Ovarian reserve (OR) demonstrates reproductive potential as the number and quality of remaining oocytes. The basal serum levels of basal follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2 ), and FSH : LH ratio, inhibit B, anti-Müllerian hormone (AMH) and antral follicle count (AFC) are parameters of OR, which have been proven to be predictors of oocyte quantity (6)(7)(8)(9)(10). Although still be controversial, they are also thought to be possible predictors of oocyte quantity (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…The basal serum levels of basal follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2 ), and FSH : LH ratio, inhibit B, anti-Müllerian hormone (AMH) and antral follicle count (AFC) are parameters of OR, which have been proven to be predictors of oocyte quantity (6)(7)(8)(9)(10). Although still be controversial, they are also thought to be possible predictors of oocyte quantity (9)(10)(11)(12). Diminished ovarian reserve (DOR) is a common phrase for evaluating the value of OR, which is important to provide the clinical counseling for women with the previous miscarriages (PMs) (4,9,13,14).…”

Section: Introductionmentioning

confidence: 99%

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Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis

Tan

Jiang

et al. 2022

Front. Endocrinol.

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The fact of ovarian reserve (OR) decreased in women with recurrent miscarriage has been well known. However, Whether OR would decrease with increasing numbers of previous miscarriages (PMs) is still unclear. To address this, OR parameters of following four groups’ patients were evaluated: 99 women with one previous miscarriage (PM1), 46 women with two previous miscarriages (PM2) and 35 women with three or more previous miscarriages (PM3). The control group included 213 women without a history of miscarriage (PM0). The correlation of OR parameters and the proportion of diminished ovarian reserve (DOR) patients between the four groups were analyzed using Kendall’s Tau-B coefficients. The results showed the median anti-Müllerian hormone (AMH) levels were 4.04, 3.40, 3.14 and 2.55 respectively in the PM0, PM1, PM2 and PM3 groups, respectively (H=15.99, P = 0.001); the median antral follicle counts (AFCs) were 10, 8, 8 and 6, respectively (H=24.53, P < 0.001); and the proportions of DOR patients were 10.8%, 15.2%, 23.9% and 31.4% (χ2 = 13.01, P = 0.005). In addition, AMH level and AFC correlated negatively with the number of PMs (correlation coefficients -0.154, P < 0.001; -0.205, P < 0.001 respectively), the proportion of DOR patients correlated positively with the number of PMs (correlation coefficients 0.156, P = 0.001). After stratification by age, AMH and AFC levels were still significantly lower in the PM3 group than the PM0 group (P < 0.05). The proportion of DOR patients between the PM0 and PM3 groups was statistically significant (P < 0.001). This study showed that AMH levels and AFCs decreased as well as the proportion of DOR patients increased significantly as the number of PMs increased. In conclusion, our study indicates decreased AMH levels and AFCs might be one of the factors contributing to early miscarriage.

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Section: The Relationship Between the Pm0 And Pm3 Groups And Ormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis

Tan

Jiang

et al. 2022

Front. Endocrinol.

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“…Anti-Müllerian hormone (AMH) is a well-established marker for ovarian reserve and found to correlate with several outcomes in reproductive medicine, most reliably oocyte yield during ART cycles [1][2][3][4]. AMH, by some studies, has been shown to have a moderate association with implantation, clinical pregnancy, and live birth for both fresh and frozen transfers [5][6][7][8][9][10][11]. It has also been shown to correlate with amenorrhea and PCOS severity, risk of premature ovarian insufficiency, and onset of Li et al Reproductive Biology and Endocrinology (2023) 21:19 menopause [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

Seifer

Tal

2023

Reprod Biol Endocrinol

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Background While anti-Müllerian hormone (AMH) predicts quantitative IVF outcomes such as oocyte yield, it is not certain whether AMH predicts markers of oocyte quality such as aneuploidy. Methods Retrospective case–control analysis of the SART-CORS database, 2014–2016, to determine whether anti-Müllerian hormone (AMH) predicts aneuploidy and live birth in IVF cycles utilizing preimplantation genetic testing for aneuploidy (PGT-A). Results Of 51,273 cycles utilizing PGT-A for all embryos, 10,878 cycles were included in the final analysis; of these, 2,100 cycles resulted in canceled transfer due to lack of normal embryos and 8,778 cycles resulted in primary FET. AMH levels of cycles with ≥ 1 euploid embryo were greater than those of cycles with no normal embryos, stratifying by number of embryos biopsied (1–2, 3–4, 5–6, and ≥ 7), P < 0.017 for each stratum. Adjusting for age and number of embryos biopsied, AMH was a significant independent predictor of ≥ 1 euploid embryo for all age groups: < 35 yrs (aOR 1.074; 95%CI 1.005–1.163), 35–37 years (aOR 1.085; 95%CI 1.018–1.165) and ≥ 38 years (aOR 1.055; 95%CI 1.020–1.093). In comparative model analysis, AMH was superior to age as a predictor of ≥ 1 euploid embryo for age groups < 35 years and 35–37 years, but not ≥ 38 years. Across all cycles, age (aOR 0.945, 95% CI 0.935–0.956) and number of embryos (aOR 1.144, 95%CI 1.127–1.162) were associated with live birth per transfer, but AMH was not (aOR 0.995, 95%CI 0.983–1.008). In the subset of cycles resulting in ≥ 1 euploid embryo for transfer, neither age nor AMH were associated with live birth. Conclusions Adjusting for age and number of embryos biopsied, AMH independently predicted likelihood of obtaining ≥ 1 euploid embryo for transfer in IVF PGT-A cycles. However, neither age nor AMH were predictive of live birth once a euploid embryo was identified by PGT-A for transfer. This analysis suggests a predictive role of AMH for oocyte quality (aneuploidy risk), but not live birth per transfer once a euploid embryo is identified following PGT-A.

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A diagnosis of diminished ovarian reserve does not impact embryo aneuploidy or live birth rates compared to patients with normal ovarian reserve

Fouks

Penzias

Neuhausser

et al. 2022

Fertility and Sterility

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Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

Cited by 4 publications

References 5 publications

Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis

Decreased Ovarian Reserves With an Increasing Number of Previous Early Miscarriages: A Retrospective Analysis

AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

A diagnosis of diminished ovarian reserve does not impact embryo aneuploidy or live birth rates compared to patients with normal ovarian reserve

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