Connecting the dots in type 1 diabetes: The role for gut–pancreas axis

Menezes-Silva, Luísa; Fonseca, Denise Morais da

doi:10.1002/jlb.3ce0719-242r

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Changes of microbiota may lead to systemic immune impairment. Such a close interaction between changes of microbiota, cytokines, and pancreas has been considered as the gut-pancreas axis theory [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Chen

Mao

et al. 2020

Gastroenterology Research and Practice

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Background/Objectives. This systematic review was conducted to investigate the association between pancreatitis and IBD. Methods. MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance. Results. Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28; P<0.00001) and UC (OR, 2.49; 95% CI, 1.91-3.26; P<0.00001). Increased risks of CD (OR, 12.90; 95% CI, 5.15-32.50; P<0.00001) and UC (OR, 2.80; 95% CI, 1.00-7.86; P=0.05) were found in patients with chronic pancreatitis. As for patients with acute pancreatitis, there were significant association of CD (OR, 3.70; 95% CI, 1.90-7.60; P=0.0002), but were not UC. Conclusions. The evidence confirmed an association between pancreatitis and IBD. When pancreatitis patients have chronic diarrhea and mucus blood stool or IBD patients have repeated abdominal pain and weight loss, they should consult pancreatic and gastrointestinal specialists.

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Section: Discussionmentioning

confidence: 99%

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Chen

Mao

et al. 2020

Gastroenterology Research and Practice

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“…The increase in intestinal membrane permeability allows harmful metabolites in the intestine to reach the corresponding target organs through body fluid circulation, causing inflammation and the subsequent development of obesity and diabetes 21 , 59 . Disruption of the physical intestinal barrier and increased intestinal membrane permeability in high-GLU-treated mice leads to an increased inflammatory environment and damage to the pancreas through the gut-pancreas axis 18 . In the present study, the intestinal tight junction proteins Claudin 1 and Occludin were significantly downregulated in the high-glucose TD broilers, suggesting that the intestinal barrier had been damaged, and the DAO content in plasma had increased, suggesting increased intestinal permeability.…”

Section: Discussionmentioning

confidence: 99%

“…The gut-pancreas axis plays a key role in regulating glucose homoeostasis and may be involved in the treatment of type 2 diabetes, hypoglycaemia and hyperinsulinaemia [17][18][19] . When stimulated by nutrition, the gut secretes a number of peptide hormones to increase insulin release, while insulin secretion is also regulated by the G protein-coupled receptor (GPCR) 17,20 .…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis

Chen

Zhang

et al. 2023

npj Biofilms Microbiomes

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Tibial dyschondroplasia (TD) with multiple incentives is a metabolic skeletal disease that occurs in fast-growing broilers. Perturbations in the gut microbiota (GM) have been shown to affect bone homoeostasis, but the mechanisms by which GM modulates bone metabolism in TD broilers remain unknown. Here, using a broiler model of TD, we noted elevated blood glucose (GLU) levels in TD broilers, accompanied by alterations in the pancreatic structure and secretory function and damaged intestinal barrier function. Importantly, faecal microbiota transplantation (FMT) of gut microbes from normal donors rehabilitated the GM and decreased the elevated GLU levels in TD broilers. A high GLU level is a predisposing factor to bone disease, suggesting that GM dysbiosis-mediated hyperglycaemia might be involved in bone regulation. 16S rRNA gene sequencing and short-chain fatty acid analysis revealed that the significantly increased level of the metabolite butyric acid derived from the genera Blautia and Coprococcus regulated GLU levels in TD broilers by binding to GPR109A in the pancreas. Tibial studies showed reduced expression of vascular regulatory factors (including PI3K, AKT and VEFGA) based on transcriptomics analysis and reduced vascular distribution, contributing to nonvascularization of cartilage in the proximal tibial growth plate of TD broilers with elevated GLU levels. Additionally, treatment with the total flavonoids from Rhizoma drynariae further validated the improvement in bone homoeostasis in TD broilers by regulating GLU levels through the regulation of GM to subsequently improve intestinal and pancreatic function. These findings clarify the critical role of GM-mediated changes in GLU levels via the gut–pancreas axis in bone homoeostasis in TD chickens.

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“…2019 ). Type one DM (T1D) and type two DM (T2D) are the most common and are caused by pancreatic β-cells insulin-production failure and acquired insulin resistance, respectively ( Menezes-Silva and Fonseca 2019 ). In T1D, this is caused by the self-destruction of insulin producing pancreatic cells by the immune system ( Boerner and Sarvetnick 2011 ).…”

Section: Systemic Disease and The Oral Microbiomementioning

confidence: 99%

Studying ancient human oral microbiomes could yield insights into the evolutionary history of noncommunicable diseases

Gancz

Weyrich

2023

F1000Res

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Noncommunicable diseases (NCDs) have played a critical role in shaping human evolution and societies. Despite the exceptional impact of NCDs economically and socially, little is known about the prevalence or impact of these diseases in the past as most do not leave distinguishing features on the human skeleton and are not directly associated with unique pathogens. The inability to identify NCDs in antiquity precludes researchers from investigating how changes in diet, lifestyle, and environments modulate NCD risks in specific populations and from linking evolutionary processes to modern health patterns and disparities. In this review, we highlight how recent advances in ancient DNA (aDNA) sequencing and analytical methodologies may now make it possible to reconstruct NCD-related oral microbiome traits in past populations, thereby providing the first proxies for ancient NCD risk. First, we review the direct and indirect associations between modern oral microbiomes and NCDs, specifically cardiovascular disease, diabetes mellitus, rheumatoid arthritis, and Alzheimer's disease. We then discuss how oral microbiome features associated with NCDs in modern populations may be used to identify previously unstudied sources of morbidity and mortality differences in ancient groups. Finally, we conclude with an outline of the challenges and limitations of employing this approach, as well as how they might be circumvented. While significant experimental work is needed to verify that ancient oral microbiome markers are indeed associated with quantifiable health and survivorship outcomes, this new approach is a promising path forward for evolutionary health research.

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Connecting the dots in type 1 diabetes: The role for gut–pancreas axis

Abstract: Discussion on changes in gut microbiota driving the breakdown of mucosal barrier in NOD mice; the resulting inflammation and impairment of oral tolerance induces the autoimmune diabetes.

Cited by 8 publications

References 10 publications

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis

Studying ancient human oral microbiomes could yield insights into the evolutionary history of noncommunicable diseases

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