Connection between polymorphisms in HTR2A, TPH2, BDNF, TOMM40 genes and the successful mastering of human–computer interfaces

Turovsky, Ya. A.; Gureev, Artem P.; Vitkalova, Inna Yu; Popov, Vasily N.

doi:10.1007/s12041-019-1138-6

Cited by 2 publications

(5 citation statements)

References 21 publications

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“…Earlier results from our group have shown that, on the contrary, carriers of the T allele gave more correct commands. However, these studies involved an electromyographic interface, not VOI [9]. The C allele of the rs6313 polymorphism increases the efficiency of protein translation and concentration of the 5-HT2A receptor, which plays a crucial role in serotonin metabolism [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Genotyping was performed via polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis according to previously described methods [9]. PCR was performed using a Bio-Rad CFX96 T M system (Bio-Rad, USA) with HS SYBR qPCR mix (Evrogen, Russia).…”

Section: Pcr-rflp Analysismentioning

confidence: 99%

“…Our preliminary results have demonstrated connections between the number of single nucleotide polymorphisms (SNPs) and values of systemic behavior during device operation (accuracy of achieving goals, characteristics of subjective time scales) [9,10], as well as characteristics of biomedical signals, such heart rate variability [11]. Previous studies have shown that SNPs in a gene encoding a protein involved in serotonin metabolism are associated with the mastery of the electromyographic interface [9]. Of particular interest are polymorphism in the brain-derived neurotrophic factor (BDNF) gene (such as rs6265 and rs2030324), which is responsible for the regulation of the maturation and differentiation of neurons and forming of working memory [12] and long-term potentiation [13].…”

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

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The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Turovsky¹,

Gureev²,

Vitkalova³

et al. 2021

J. Integr. Neurosci.

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A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.

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Section: Discussionmentioning

confidence: 99%

Section: Pcr-rflp Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

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The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Turovsky¹,

Gureev²,

Vitkalova³

et al. 2021

J. Integr. Neurosci.

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“…Ранее нами было показано, что успешность освоения интерфейсов находится в тесной взаимосвязи с особенностями генотипа оператора, в частности, с полиморфизмами генов, которые участвуют в метаболизме серотонина [21]. Мы предполагаем, что параметры ВСР пользователей интерфейсов «мозг-компьютер», окулографических, дыхательных и мио- графических интерфейсов также могут зависеть от SNV (single nucleotide variation) в генах, которые так или иначе связаны с функционированием вегетативной нервной системы.…”

Section: Introductionunclassified

Genetic Features of Dynamics of Heart Rate Variability at Work with Perspective Human — Computers Interfaces

Turovskiy

Gureev

Vitkalova

et al. 2021

Experimental Psychology (Russia)

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The aim of the work was to assess the parameters of the heart rate variability of the user by the interfaces of the brain-computer, oculographic, respiratory, myographic, depending on the SNV in the genes that are somehow related to the functioning of the autonomic nervous system. Heart rate variability is an indicator of the cardiovascular system and a number of mechanisms regulating the whole organism, which can be used as one of the markers of the state of a human operator. The paper analyzes the association of point mutations of the HTR2A, APOE and TPH2 genes with HRV indices when users master a number of human-computer interfaces: brain-computer, oculographic, myographic and respiratory. The brain-computer interface is implemented on stable (well-established) visual evoked potentials; oculographic interface provided a set of text by eye movement, myographic provided the same task as the two above interfaces, due to changes in the user’s muscular activity; respiratory interface — due to changes in breathing. It has been shown that the SNV of the HTR2A and TPH2 genes involved in serotonin metabolism are associated with HRV indices in the development of neurocomputer interfaces. The SNV rs6313 HTR2A C allele carriers are characterized by higher rates of tonic effects on HRV when working with the oculographic interface, which is probably associated with an increase in serotonin receptor expression, which is involved in the vegetative regulation of heart rhythm. The genotype T / T SNV rs4290270 of the TPH2 gene is associated with a large spread of cardiointervals. This is probably due to an increase in the expression of the TPH2 gene, which catalyzes the limiting step of serotonin synthesis.

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Connection between polymorphisms in HTR2A, TPH2, BDNF, TOMM40 genes and the successful mastering of human–computer interfaces

Cited by 2 publications

References 21 publications

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface

Genetic Features of Dynamics of Heart Rate Variability at Work with Perspective Human — Computers Interfaces

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