The results of the research presented in the article elucidate the importance of taking into account the amplitude-frequency characteristics of soil stratum models in the context of seismic safety of construction objects on the territory of Ukraine, in different regions. The presented results of the analysis of the calculated amplitude-frequency characteristics of models of soil environments for different regions of Ukraine reveal that the amplification of vibrations by soils has a complex nature that depends on many factors and can differ significantly for different construction sites. We have shown that during the earthquake-resistant design of buildings and structures, it is necessary to properly take into account the properties of soil complexes under the research site, which can significantly increase oscillations at “resonant” frequencies. The article examines in detail the features of amplitude-frequency characteristic models of soil strata for different geological conditions in Kyiv, Kryvyi Rih and Odesa. The purpose of this study is to compare these characteristics and develop recommendations for reducing risks associated with seismic hazards.