It is widely recognized that affect and cognition can have a profound influence on information behavior. However, how these factors affect information behavior in the context of chronic, stigmatized conditions is less clear. This study employed a qualitative approach to explore the interrelatedness of affect, cognition, and information behavior among persons with fibromyalgia. Persons with fibromyalgia were recruited using multiple recruitment strategies (e.g., listservs and social media) for an interview study. The interview guided participants to tell their story as they drew a timeline. Data were analyzed using qualitative data analysis methods based on the Grounded Theory Methodology. Participants' narratives illustrated that affect and cognition had diverse effects on participants' information and health behaviors: uncertainty and negative affect promoted information seeking; affect and information facilitated reconceptualization and self-growth; and online venues facilitated venting, gave rise to validating experiences, and provided opportunities to help others. This study's findings contribute to extant knowledge by connecting affect, cognition, and action in long-term health management. The study also provides recommendations for practice: a need to focus on practical management strategies in information provision, develop information resources to address the needs of diverse populations, and promote empathy and awareness concerning invisible conditions.