2023
DOI: 10.3389/fendo.2023.1253584
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Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical atherosclerosis in children with obesity

Monica Simina Mihuta,
Corina Paul,
Andreea Borlea
et al.

Abstract: IntroductionChildhood obesity leads to early subclinical atherosclerosis and arterial stiffness. Studying biomarkers like trimethylamine N-oxide (TMAO), linked to cardio-metabolic disorders in adults, is crucial to prevent long-term cardiovascular issues.MethodsThe study involved 70 children aged 4 to 18 (50 obese, 20 normal-weight). Clinical examination included BMI, waist measurements, puberty stage, the presence of acanthosis nigricans, and irregular menstrual cycles. Subclinical atherosclerosis was assesse… Show more

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“…Nonetheless, the role of gut microbiota and its metabolites in cardiovascular diseases has been extensively reported [2,14,15]. For PAH, a growing corpus of research implicates gut microbiota, particularly bacteria, as significant contributors to the pathophysiological landscape of PAH [16].…”
Section: Discussionmentioning
confidence: 99%
“…Nonetheless, the role of gut microbiota and its metabolites in cardiovascular diseases has been extensively reported [2,14,15]. For PAH, a growing corpus of research implicates gut microbiota, particularly bacteria, as significant contributors to the pathophysiological landscape of PAH [16].…”
Section: Discussionmentioning
confidence: 99%