Connective Tissue and the Pentose Phosphate Pathway in Normal and Denervated Muscle

Garcia‐Buñuel, Luis; Garcia-Buñuel, Virginia M.

doi:10.1038/213913a0

Cited by 21 publications

(6 citation statements)

References 14 publications

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“…However, most of the previous studies were using muscle specimens taken at an advanced stage of the disease. Macrophages and lipid cells, commonly found in muscle at the advanced stage, are rich in some of the enzymes regulating the metabolism of oxygen free radicals (23)(24)(25). Therefore, the possibility that the observed changes might be secondary to infiltration cannot entirely be excluded.…”

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confidence: 99%

Pathogenesis of progressive muscular dystrophy: studies on free radical metabolism in an animal model

Ohta

Muzuno

1988

Acta Neurologica Scandinavica

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Evidence to suggest the presence of abnormal metabolism of oxygen free radicals in progressive muscular dystrophy is presented using an animal model. In the superficial pectoral muscles of dystrophic chickens, enzyme activities regulating the metabolism of oxygen free radicals, i.e., catalase, superoxide dismutases and glutathione peroxidase, were significantly elevated within 1 week of hatching. Activities of related enzymes, i.e., glutathione reductase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase were also elevated. In contrast, the specific activity of phosphofructokinase, the rate-limiting enzyme of the glycolytic pathway, was normal during the first 4-week period. These results suggest that there is an increased turnover of oxygen free radicals in the dystrophic muscle. This concept appears important in a further investigation of the pathogenesis and treatment of progressive muscular dystrophies.

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confidence: 99%

Pathogenesis of progressive muscular dystrophy: studies on free radical metabolism in an animal model

Ohta

Muzuno

1988

Acta Neurologica Scandinavica

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“…Diese Termini geben die differenzierte Auffassung zur Histogenese und Dignität des KMN wieder. Zwischenzeitlich hat sich der Begriff "congenital mesoblastic nephroma" weitgehend durchgesetzt (Bolande et al, 1967 (8,16,18,19,25,44). Der dysontogenetische Ursprung ist jedoch keineswegs endgültig bewiesen.…”

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“…5). Elektronenmikroskopisch wurde im Rezidivtumor die Ähnlichkeit zu pri• mitiven, unreifen fetalen Fibroblasten festgestellt, während der Primärtumor reife Fibroblasten aufwies (8,18,19).…”

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Konnatales mesoblastisches Nephrom im Säuglingsalter - Übersicht zur Rezidivhäufigkeit und zu Therapieergebnissen von 74 Fällen

1980

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The congenital mesoblastic nephroma is clearly distinguishable from Wilms' tumour. Almost exclusively it becomes manifest in early infancy. From the literature 71 established cases were complied, 3 own cases have been added. By many authors this tumour was characterized as benign. There has been, however, a total of 7 recurrences. An epicritical review is given of the course of one own case. The complications arising from radio-and chemotherapy clearly indicate that surgery is the method of choice of semi-malignant tumour.

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“…Bunuel, 1967). which can be accounted for by fc 1.1.1.49, G6PDH) plays a role in glucose me-its role in the pentose phosphate pathway.…”

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confidence: 99%

“…Hence, high levels of G6PDH are found in tissues synthesizing high levels of DNA and RNA (rapidly proliferating or regenerating cells), lipids (fatty tissue or membrane) or steroids (mammary gland or adrenal medul la). Elevated levels of G6PDH have been ob served in muscle in a variety of nonfunctional states, such as denervation [Garcia-Bunuel and Garcia-Bunuel, 1967;Wagner and Max, 1979], crushed nerve denervation [Max et al, 1981], administration of a myotoxic local anesthetic [Wagner et al, 1978], mechanical immobilization [Garcia-Bunuel and GarciaBunuel, 1980], muscular dystrophy [Mizuno, 1985], and infantile spinal muscular atrophy [Meijer et al, 1977]. Max et al [1981] have shown that the rate of increase of muscle G6PDH induced by nerve crush denervation is related to the length of the remaining nerve stump: the longer the nerve stump, the slower the increase in G6PDH.…”

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confidence: 99%

Changes in Glucose 6-Phosphate Dehydrogenase Activity in Developing Embryonic Chick Skeletal Muscle and Spinal Cord

Lyles¹,

Weill²

1986

Dev Neurosci

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Glucose 6-phosphate dehydrogenase (G6PDH) activity was examined in the developing embryonic chick in brachial and lumbar spinal cord and pectoral and leg muscle. Enzyme activity was generally highest at the earliest stage examined, embryonic day 5. The developmental profiles for G6PDH activity in the two muscles were similar: a sharp initial decrease occurred between days 5 and 9, with relatively low levels present by day 18; peaks of G6PDH activity at days 12 and 16 were more prominent in leg muscle. Similar levels of G6PDH were also detected in spinal cord with the developmental profile in the brachial spinal cord resembling that seen in, muscle. In lumbar spinal cord, initial G6PDH activity was lower than in brachial spinal cord; the developmental profile, however, resembled that seen in the brachial spinal cord, with an initial drop in enzyme activity seen between days 5 and 7. Neural regulation of G6PDH activity in mature muscle is believed to repress enzyme synthesis. The drop in G6PDH activity observed in embryonic spinal cord and muscle between days 5 and 9 coincides with the initiation of functional neuromuscular contacts. Hence, the normal regulation of G6PDH during embryonic development may involve the repression of G6PDH in spinal cord neurons and muscle, possibly effected by their interaction.

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Connective Tissue and the Pentose Phosphate Pathway in Normal and Denervated Muscle

Cited by 21 publications

References 14 publications

Pathogenesis of progressive muscular dystrophy: studies on free radical metabolism in an animal model

Pathogenesis of progressive muscular dystrophy: studies on free radical metabolism in an animal model

Konnatales mesoblastisches Nephrom im Säuglingsalter - Übersicht zur Rezidivhäufigkeit und zu Therapieergebnissen von 74 Fällen

Changes in Glucose 6-Phosphate Dehydrogenase Activity in Developing Embryonic Chick Skeletal Muscle and Spinal Cord

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