Connectivity analysis of EEG under drug therapy

Abstract

Analysis of human EEG constitutes a useful instrument for the evaluation of drug bioavailability at the brain. Linear and nonlinear techniques were applied to EEG signals for the assessment of brain connectivity after drug intake by coherence and cross mutual information, respectively. The main goal was to evaluate the pharmacological effect of different doses of alprazolam on the brain during wakefulness. Preliminary results reported in this work showed statistically significant differences in EEG channels coupling between the states corresponding to placebo and different drug doses. However, nonlinear variables correlated better with the expected within-doses and within-time effects.

Scalp EEG brain functional connectivity networks in pediatric epilepsy

“…Assessment of functional connectivity network (FCN) in patients suffering with various neurological disorders (e.g. Epilepsy in our study) through modalities such as EEG recording has elicited new findings in ways of underlying distinctions that delineate epileptic from control populations [4,10,21,32,36,43,44,46].…”

“…Scalp EEG has gained significant prominence for assessing brain function in patients with different neurological disorders, among them epilepsy. These include surveying the response of the brain under the influence of drug therapies [4,38,44], source localization of epileptic seizures which exploits techniques in the time/frequency domains for analysis of individual EEG electrode recordings [2,3], to name a few. Assessment of functional connectivity network (FCN) in patients suffering with various neurological disorders (e.g.…”

A probabilistic approach for pediatric epilepsy diagnosis using brain functional connectivity networks

“…Analysis of Scalp EEG during resting state condition, without performing a cognitive task and with the absence of external stimuli, has gained significant prominence for assessing brain function and related disorders. Applications include tasks that require assessing responses of the brain under the influence of different drug therapies [ 3 ], and tasks that rely on determining the 3D source localization of epileptic seizures which exploits techniques in the time/frequency domains for analysis of individual EEG electrode recordings [ 4 , 5 ]. Assessment of brain functional connectivity network in patients suffering with various neurological disorders through modalities such as EEG recording, Magnetoencephalography (MEG) and functional Magnetic Resonance Imaging (fMRI) has elicited new findings in ways of underlying distinctions that delineate epileptic from control populations [ 6 - 14 ].…”

Multimodal EEG Recordings, Psychometrics and Behavioural Analysis

“…Also inconsistencies could occur; for example, with benzodiazepines there is consensus that alpha band power decreases, but when longitudinal (sensor space) coherent activity was analysed in this band, no drug effect was found [92]. For these resting state and possible other observations there definitely is room for improvement.…”