Connectivity between the anterior insula and dorsolateral prefrontal cortex links early symptom improvement to treatment response

Yuan, Hsinsung; Zhu, Xiao; Tang, Weijun; Cai, Yao; Shi, Sheng; Luo, Qiang

doi:10.1016/j.jad.2019.09.041

Cited by 26 publications

(17 citation statements)

References 97 publications

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“…As a consequence, the DLPFC is a preferred target region for therapeutic brain stimulation in such patients (Noda et al, 2017;Chen et al, 2019). Particularly, the connectivity between the DLPFC and the anterior insula seems to be important for mood regulation: A positive response to medical depression treatment was correlated with an increase in resting-state connectivity between anterior insula and the DLPFC (Yuan et al, 2020).…”

Section: Mood Regulationmentioning

confidence: 99%

The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing

Hertrich

Dietrich

Blum

et al. 2021

Front. Hum. Neurosci.

106

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This review article summarizes various functions of the dorsolateral prefrontal cortex (DLPFC) that are related to language processing. To this end, its connectivity with the left-dominant perisylvian language network was considered, as well as its interaction with other functional networks that, directly or indirectly, contribute to language processing. Language-related functions of the DLPFC comprise various aspects of pragmatic processing such as discourse management, integration of prosody, interpretation of nonliteral meanings, inference making, ambiguity resolution, and error repair. Neurophysiologically, the DLPFC seems to be a key region for implementing functional connectivity between the language network and other functional networks, including cortico-cortical as well as subcortical circuits. Considering clinical aspects, damage to the DLPFC causes psychiatric communication deficits rather than typical aphasic language syndromes. Although the number of well-controlled studies on DLPFC language functions is still limited, the DLPFC might be an important target region for the treatment of pragmatic language disorders.

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Section: Mood Regulationmentioning

confidence: 99%

The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing

Hertrich

Dietrich

Blum

et al. 2021

Front. Hum. Neurosci.

106

View full text Add to dashboard Cite

show abstract

“…In another study of old MDD patients (> 60 years old), a better response to sertraline was found to be associated with greater connectivity between the left pars triangularis of the IFG and the left frontal eye field (FEF) located in the frontal cortex [ 115 ]. Recently, Yuan and coauthors found that decreased resting-state FC between the right anterior insula and the left PFC was linked to early symptom improvement by sertraline treatment, including improvements in self-perceptual anxiety, somatic symptoms, and insomnia [ 116 ]. Interestingly, these treatment-related brain connectivity changes by SSRIs might be dependent on the serum TNF-α level in MDD patients [ 117 ].…”

Section: Brain Functional Connectome For Evaluating Treatment Efficacymentioning

confidence: 99%

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

et al. 2021

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Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis. We also highlighted the utility of brain functional connectome for differentiating MDD from other similar psychiatric disorders, predicting recurrence and suicide attempts in MDD, and evaluating treatment responses. Converging evidence has now linked aberrant brain functional network organization in MDD to the dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the neurobiological mechanisms of the disease and antidepressant efficacy. Widespread connectome dysfunctions in MDD patients include multiple, large-scale brain networks as well as local disturbances in brain circuits associated with negative and positive valence systems and cognitive functions. Although the clinical utility of the brain functional connectome remains to be realized, recent findings provide further promise that research in this area may lead to improved diagnosis, treatments, and clinical outcomes of MDD.

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“…Aberrant insula-prefrontal connectivity has shown higher hyperactivity to threat stimulus in individuals with SAD compared to HCs (Klumpp et al, 2012). Recently, functional MRI studies have reported that the individuals with SAD group exhibit greater activation in the bilateral posterior insula during a social performing task compared to HCs, which may reflect premature markers in self-perceptual SAD Yuan et al, 2020). Functional neuroimaging experiments on SAD focus on regional neural activity in response to anxiety, provocation, or emotional facial cues.…”

Section: Functional Connectivitymentioning

confidence: 99%

Review of EEG, ERP, and Brain Connectivity Estimators as Predictive Biomarkers of Social Anxiety Disorder

et al. 2020

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Social anxiety disorder (SAD) is characterized by a fear of negative evaluation, negative self-belief and extreme avoidance of social situations. These recurrent symptoms are thought to maintain the severity and substantial impairment in social and cognitive thoughts. SAD is associated with a disruption in neuronal networks implicated in emotional regulation, perceptual stimulus functions, and emotion processing, suggesting a network system to delineate the electrocortical endophenotypes of SAD. This paper seeks to provide a comprehensive review of the most frequently studied electroencephalographic (EEG) spectral coupling, event-related potential (ERP), visualevent potential (VEP), and other connectivity estimators in social anxiety during rest, anticipation, stimulus processing, and recovery states. A search on Web of Science provided 97 studies that document electrocortical biomarkers and relevant constructs pertaining to individuals with SAD. This study aims to identify SAD neuronal biomarkers and provide insight into the differences in these biomarkers based on EEG, ERPs, VEP, and brain connectivity networks in SAD patients and healthy controls (HC). Furthermore, we proposed recommendations to improve methods of delineating the electrocortical endophenotypes of SAD, e.g., a fusion of EEG with other modalities such as functional magnetic resonance imaging (fMRI) and magnetoencephalograms (MEG), to realize better effectiveness than EEG alone, in order to ultimately evolve the treatment selection process, and to review the possibility of using electrocortical measures in the early diagnosis and endophenotype examination of SAD.

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Connectivity between the anterior insula and dorsolateral prefrontal cortex links early symptom improvement to treatment response

Cited by 26 publications

References 97 publications

The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing

The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome

Review of EEG, ERP, and Brain Connectivity Estimators as Predictive Biomarkers of Social Anxiety Disorder

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