Connectivity characterization of the mouse basolateral amygdalar complex

Hintiryan, Houri; Bowman, Ian; Johnson, David Linton; Korobkova, Laura; Zhu, Muye; Khanjani, Neda; Gou, Lin; Gao, Lei; Yamashita, Seita; Bienkowski, Michael S.; Garcia, Luis; Foster, Nicholas N.; Benavidez, Nora L.; Song, Monica Y.; Lo, D.C.W.; Cotter, Kaelan; Becerra, Marlene; Aquino, Sarvia; Cao, Chunru; Cabeen, Ryan P.; Stanis, Jim; Fayzullina, Marina; Ustrell, Sarah; Boesen, Tyler; Zhang, Zhenggang; Fanselow, Michael S.; Golshani, Peyman; Hahn, Joel D.; Wickersham, Ian R.; Ascoli, Giorgio A.; Zhang, Li I.; Dong, Hong‐Wei

doi:10.1101/807743

Cited by 5 publications

(8 citation statements)

References 148 publications

(184 reference statements)

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“…These medial SC zones send outputs to the RE, CM, and IAM shown to be activated during arousal and the presence of visual threats 69,70 . Our results also reveal an interesting divergent ILA→SC.m/l projection pathway that is consistent with the role of ILA in mediating fear extinction, risk assessment and evaluation to threat situations, particularly to looming stimuli and predators 17,18,57,71 .…”

Section: Cortico-tectal Subnetwork In Defensive/aggressive Behaviorssupporting

confidence: 86%

The mouse cortico-tectal projectome

Benavidez

Bienkowski

Khanjani

et al. 2020

Preprint

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The superior colliculus (SC) is a midbrain structure that receives diverse and robust cortical inputs to drive a range of cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical inputs arising from higher-order associative areas coordinate with SC sensorimotor networks to influence its outputs. In this study, we constructed a comprehensive map of all cortico-tectal projections and identified four collicular zones with differential cortical inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) and lateral (SC.l). Computational analyses revealed that cortico-tectal projections are organized as multiple subnetworks that are consistent with previously identified cortico-cortical and cortico-striatal subnetworks. Furthermore, we delineated the brain-wide input/output organization of each collicular zone and described a subset of their constituent neuronal cell types based on distinct connectional and morphological features. Altogether, this work provides a novel structural foundation for the integrative role of the SC in controlling cognition, orientation, and other sensorimotor behaviors.3

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Section: Cortico-tectal Subnetwork In Defensive/aggressive Behaviorssupporting

confidence: 86%

The mouse cortico-tectal projectome

Benavidez

Bienkowski

Khanjani

et al. 2020

Preprint

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“…The highly coherent behavioral manifestations also lend a strong support for the imperativeness of delta oscillations, which serve as the basic or natural frequencies of the telencephalic networks. It is of note that MD, prelimbic cortex, and contralateral BLA ( Figure 7 ) are all telencephalic structures receiving direct glutamatergic input from left BLA ( McDonald, 1987 , Mátyás et al., 2014 , Hintiryan et al, 2019 ; Huang et al., 2019 ; Hsu et al., 2020 ). In contrast to the potential role of INs in local spreading (see above), PN probably is essential for distant or long-range projection of the oscillating activities.…”

Section: Discussionmentioning

confidence: 99%

Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission

et al. 2020

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Summary Epileptic seizures constitute a common neurological disease primarily diagnosed by characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or electroencephalograms. With a basolateral amygdala (BLA) kindling model, we found that the dominant frequency of BLA oscillations is in the delta range (1–5 Hz) in both normal and seizure conditions. Multi-unit discharges are increased with higher seizure staging but remain phase-locked to the delta waves in LFPs. Also, the change in synchrony precedes and outlasts the changes in discharging units as well as behavioral seizures. One short train of stimuli readily drives the pyramidal-inhibitory neuronal networks in BLA slices into prolonged reverberating activities, where the burst and interburst intervals may concurrently set a “natural wavelength” for delta frequencies. Seizures thus could be viewed as erroneous temporospatial continuums to normal oscillations in a system with a built-in synchronizing and resonating nature for information relay.

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“…While the LS is critical for controlling responses to social novelty (16)(17)(18)(19), the brain regions that transmit information to the LS for proper execution of social novelty discrimination have not been identified. We noted the BLA and the vCA1 as candidate regions because both have established roles in regulating social novelty (9,16,47) and recognition (23,48,49), and send projections to the LS (22,26). To determine the importance of projections from the BLA or vCA1 to the LS in controlling social novelty behavior, we used a diphtheria toxin A (DtA)mediated viral circuit elimination strategy.…”

Section: Bla Projections But Not Vca1 Projections To the Ls Are Necessary For Social Novelty Discriminationmentioning

confidence: 99%

“…Investigation of the LS in rodents demonstrated its involvement in social saliency (15,16), social recognition (17- 19), and social aggression (20,21). The LS is also innervated by many regions involved in regulating various social behaviors, including the basolateral amygdala (BLA) (22), ventral hippocampus CA1 area (vCA1) (23), ventral tegmental area (9,24), as well as the infralimbic and prelimbic cortices (9,25,26).…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that 1) TrkB signaling in LS GABAergic neurons is important for regulating rodent social behavior, and that 2) neuronal projections from BDNF-rich limbic regions serve as a source of BDNF to activate TrkB signaling in LS to control this behavior. Key candidate regions included the BLA and vCA1 because both regions highly express BDNF (44), send projections to the LS (20,22,26), and have established roles in regulating social novelty (9,16,47) and recognition (23,48,49). Indeed, local knockdown of TrkB in the LS demonstrates a role for LS TrkB expression in social novelty and recognition behavior in mice.…”

Section: Introductionmentioning

confidence: 99%

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The basolateral amygdala to lateral septum circuit is critical for regulating sociability in mice

Rodriguez

Kim

Page

et al. 2021

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Background: The lateral septum (LS) is a critical social behavior node. The LS is activated by social novelty, and perturbing LS activity impairs social recognition. However, the neural circuits and cell signaling pathways that converge on the LS to mediate this behavior aren't known. We identify brain-derived neurotrophic factor (BDNF) in projection neurons from the basolateral amgydala (BLA) to the LS, and tropomyosin kinase B receptor (TrkB) signaling in LS neurons, as required for social novelty recognition. Methods: We used single-molecule fluorescent in-situ hybridization to quantify Ntrk2 expression in LS. Viral transgenesis was used to induce cre-recombinase mediated TrkB knockdown in LS to evaluate impact on social recognition behavior, and social novelty-induced c-Fos expression in the LS. We used viral approaches for projection-specific ablation and BDNF-depletion in BLA-LS projection neurons to assess the role of this circuit in social recognition behavior. Results: The majority of GABAergic neurons in LS express TrkB. TrkB knockdown in LS abolishes social novelty recognition, and decreases LS activation in response to social novelty. Selectively ablating BLA-LS projection neurons abolishes social novelty recognition behavior, an effect that is phenocopied by depleting BDNF in this circuit. Conclusions: BLA-LS projection neurons depend on BDNF expression to regulate social recognition in the mouse. Within the LS, neurons require intact TrkB receptor signaling to mediate this behavior.

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Connectivity characterization of the mouse basolateral amygdalar complex

Cited by 5 publications

References 148 publications

The mouse cortico-tectal projectome

The mouse cortico-tectal projectome

Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic Transmission

The basolateral amygdala to lateral septum circuit is critical for regulating sociability in mice

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