Connectivity in Antiquity

LaBianca, Oystein S.; Scham, Sandra Arnold

doi:10.4324/9781315539218

Cited by 4 publications

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“…CEA is the only blood test currently recommended for use in the surveillance of patients with CRC to aid in the detection of recurrence. 1,[16][17][18][19] However, studies have questioned the suitability of CEA for surveillance because of its low sensitivity and specificity. 20 In the current study, we used a commonly applied cutoff value of 5 ng/mL, and although specificity estimates were high, the sensitivity of CEA for recurrence was only 32%.…”

Section: Discussionmentioning

confidence: 99%

Circulating epigenetic biomarkers for detection of recurrent colorectal cancer

Symonds

Pedersen²,

Murray³

et al. 2020

Cancer

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Background The sensitive detection of recurrent colorectal cancer (CRC) by the measurement of circulating tumor DNA (ctDNA) might improve the chance of a cure. This study compared a quantitative methylated ctDNA test with carcinoembryonic antigen (CEA) in the setting of surveillance for recurrence. Methods Blood samples collected either during surveillance or within 12 months of the confirmation of recurrence were assayed for ctDNA (methylated branched‐chain amino acid transaminase 1 [BCAT1]/Ikaros family zinc‐finger 1 protein [IKZF1]) and CEA. The optimal ctDNA threshold was determined by receiver operating characteristic analysis, and the test performance for the detection of recurrence was compared with CEA (5 ng/mL threshold). Results The study cohort comprised 144 eligible patients and included 50 recurrence events. The sensitivity of the methylated ctDNA test for recurrence was 66.0% (95% confidence interval [CI], 57.1%‐69.3%), which was significantly higher than the sensitivity of CEA (31.9%; 95% CI, 22.8%‐36.6%; P < .001). The sensitivity for resectable recurrence (n = 20) was also higher (ctDNA, 60.0%; CEA, 20.0%; P = .01). The specificity did not differ between the tests (ctDNA, 97.9%; 95% CI, 93.2%‐99.6%; CEA, 96.4%; 95% CI, 91.4%‐99.0%). When adjustments were made for other predictors of the presence of recurrence, a positive ctDNA test was an independent predictor (odds ratio, 155.7; 95% CI, 17.9‐1360.6; P < .001), whereas CEA was not (odds ratio, 2.5; 95% CI, 0.3‐20.6; P = .407). Conclusions The quantitative ctDNA test showed superior sensitivity in comparison with CEA without a difference in the specificity for detecting recurrent CRC. Longitudinal studies are warranted to further assess the utility (specifically the survival benefit) of methylated BCAT1/IKZF1 ctDNA in the surveillance of patients with CRC.

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Section: Discussionmentioning

confidence: 99%

Circulating epigenetic biomarkers for detection of recurrent colorectal cancer

Symonds

Pedersen²,

Murray³

et al. 2020

Cancer

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Introduction: Archaeology and the ‘People without History’

Boivin

Frachetti

Globalization in Prehistory

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Approaching Interaction in Iron Age Sardinia: Multi-Scalar Survey Evidence from the Sinis Archaeological Project and the Progetto S’Urachi

Gosner,

Nowlin

2023

Open Archaeology

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Using west-central Sardinia as a case study, this article explores how multi-scalar survey archaeology can be used to address questions of the intensity, nature, and scale of interaction in the Iron Age central Mediterranean. This large island played an important role in Mediterranean trade networks and was frequented and settled by Phoenicians, Carthaginians, and Romans, among others over the course of the first millennium BCE. These foreign groups interacted with local Nuragic people through trade, the exchange of ideas, and genetic admixing, which led to increasing connectivity over time. Large excavations at major colonial sites and genetic studies have reinforced the perception that interactions were felt most strongly in coastal regions, while inland communities remained more isolated. Our multi-scalar survey data, drawn from site-based survey at the inland nuraghe S’Urachi and regional survey in its surrounding territory (the Sinis Archaeological Project), supply information concerning how Iron Age interactions impacted inland rural communities. These data show how interaction transformed over time, as trade increased and agriculture intensified in response to external demands. Ultimately, we suggest that survey archaeology is an important tool for illuminating multi-scalar interaction in Sardinia and elsewhere.

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Connectivity in Antiquity

Cited by 4 publications

References 0 publications

Circulating epigenetic biomarkers for detection of recurrent colorectal cancer

Circulating epigenetic biomarkers for detection of recurrent colorectal cancer

Introduction: Archaeology and the ‘People without History’

Approaching Interaction in Iron Age Sardinia: Multi-Scalar Survey Evidence from the Sinis Archaeological Project and the Progetto S’Urachi

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