2016
DOI: 10.1523/jneurosci.1975-15.2016
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Connectivity Profiles Reveal a Transition Subarea in the Parahippocampal Region That Integrates the Anterior Temporal–Posterior Medial Systems

Abstract: Traditional anatomical studies of the parahippocampal region (PHR) defined the lateral portion into two subregions, the perirhinal (PRC) and parahippocampal (PHC) cortices. Based on this organization, several models suggested that the PRC and the PHC play different roles in memory through connections with different memory-related brain networks. To identify the key components of the human PHR, we used a well accepted connection-based parcellation method on two independent datasets. Our parcellation divided the… Show more

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Cited by 37 publications
(39 citation statements)
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“…In these studies, as in our findings, the most anterior aspect of the MTL cortex responded to object stimuli, whereas the middle transitional zone of the cortex responded to both object and scene information. This transitional zone between PRC and PHC has also recently been found to have unique functional and anatomical characteristics in relation to the more anterior or posterior portions of the parahippocampal gyrus (Zhuo et al, ). Nevertheless, contrary to the selective response to scene stimuli in the posterior MTL cortex in previous studies (Litman et al, ; Staresina et al, ), our findings show that even in the posterior aspect of the gyrus (and indeed even in the posterior PHC), the activation patterns were sensitive to both object and scene familiarity.…”
Section: Discussionmentioning
confidence: 97%
“…In these studies, as in our findings, the most anterior aspect of the MTL cortex responded to object stimuli, whereas the middle transitional zone of the cortex responded to both object and scene information. This transitional zone between PRC and PHC has also recently been found to have unique functional and anatomical characteristics in relation to the more anterior or posterior portions of the parahippocampal gyrus (Zhuo et al, ). Nevertheless, contrary to the selective response to scene stimuli in the posterior MTL cortex in previous studies (Litman et al, ; Staresina et al, ), our findings show that even in the posterior aspect of the gyrus (and indeed even in the posterior PHC), the activation patterns were sensitive to both object and scene familiarity.…”
Section: Discussionmentioning
confidence: 97%
“…While atrophy is relatively homogeneous along the hippocampus in AD [Davies et al, ; Jack et al, ], it strongly predominates in the head of the hippocampus in SD [La Joie et al, ; Tan et al, ]. Interestingly, several studies have highlighted that the connectivity of hippocampus [Aggleton, ; Poppenk et al, ] but also entorhinal [Maass et al, ; Navarro Schröder et al, ] and perirhinal [Zhuo et al, ] cortices varies along the anterior–posterior axis. It is thus possible that the earliest MTL lesions occur in distinct regions in AD versus SD and that the pathology then spreads across distinct sub‐MTL networks.…”
Section: Discussionmentioning
confidence: 99%
“…There was no significant laterality effect in the PM (t(37) = .29, P = . 77) and MP subnetworks (t(37) = .98, P = .33). This connectivity difference might help to explain differentiated function of the left and right hippocampus.…”
Section: Cortico-hippocampal Network Connectivitymentioning
confidence: 99%