Connectome-scale assessment of structural and functional connectivity in mild traumatic brain injury at the acute stage

Iraji, Armin; Chen, Hanbo; Wiseman, Natalie; Zhang, Tuo; Welch, Robert D.; O’Neil, Brian J.; Kulek, Andrew; Ayaz, Syed Imran; Wang, Xiao; Zuk, Conor; Haacke, E. Mark; Liu, Tianming; Kou, Zhifeng

doi:10.1016/j.nicl.2016.06.012

Cited by 38 publications

(29 citation statements)

References 61 publications

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“…AFNI motion‐correction algorithms were used to perform more realignment steps with three angular rotations (roll, pitch, and yaw in units of degrees) and three directional displacement (in millimeters) adjustments to further minimize motion artifacts. After these correction steps, no statistical differences were observed in the previous six motion parameters and frame displacement along all temporal frames between MTBI and control groups ( P > 0.05) …”

Section: Methodsmentioning

confidence: 96%

“…After these correction steps, no statistical differences were observed in the previous six motion parameters and frame displacement along all temporal frames between MTBI and control groups (P > 0.05). 24 Data Analysis SMALL-WORLDNESS ANALYSES. A few key terminologies commonly used in graph theory [27][28][29][30] and this work include: (1) degree (D): equal to the number of connections (edges) attached to each node (ROI).…”

Section: Mri Imagingmentioning

confidence: 99%

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Small world properties changes in mild traumatic brain injury

Zhou

2016

Magnetic Resonance Imaging

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Purpose To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with post-concussive symptom (PCS). Materials and Methods Thirty patients (mean age 35 ± 13 years) with clinically defined MTBI and 45 age-matched healthy controls (mean age 37 ± 10 years) participated in the experiments. Resting-state functional MRI was performed using gradient echo planar imaging sequence with 3 Tesla MRI scanner to obtain functional small-world networks. Out of all participants, 20 MTBI patients and 20 controls had available DTI data with three b-values (0, 500, 1000) s/mm2 and 30 directions for diffuse axonal injury analyses. Results Compared with controls, MTBI patients showed lower relative betweenness centrality (P = 0.01), but significantly higher clustering coefficient (P = 0.04), and these two metrics correlated negatively in patients (r = −0.77; P < 0.001). Regions with lower betweenness centrality (e.g., frontal and occipital) corresponded with the regions of reduced FA in patients, while global FA reduction correlated with betweenness centrality (r = 0.48; P = 0.03) and clustering coefficient (r = −0.46; P = 0.04) in MTBI patients. In addition, there was significantly higher thalamocortical connectivity that correlated with clustering coefficient (r = 0.39; P = 0.03) in patients. Also, patients with higher clustering coefficient tended to have less PCS score with negative correlation (r = −0.4; P = 0.04). Conclusion Our results demonstrated significant functional small-world properties changes in patients with MTBI, and suggest decreased global efficiency, possibly due to diffuse axonal injury and local network upregulation including increased thalamo-cortical connectivity.

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Section: Methodsmentioning

confidence: 96%

Section: Mri Imagingmentioning

confidence: 99%

Small world properties changes in mild traumatic brain injury

Zhou

2016

Magnetic Resonance Imaging

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“…For example, out of 25 resting-state functional magnetic resonance imaging (rs-fMRI) studies of mTBI, 6 showed only increased FC, [17][18][19][20][21][22] 9 showed only decreased FC, [23][24][25][26][27][28][29][30][31][32] and 10 showed both increased FC in some brain networks/regions and decreased FC in other networks/regions. [33][34][35][36][37][38][39][40][41] Twenty-one of these rs-fMRI studies were concerned with blunt mTBI whereas only four were related to blast mTBI. In the four blast mTBI studies, Gilmore and colleagues found reduced FC between visual network regions and other brain areas, 23 Robinson and colleagues found decreased FC of bilateral primary somatosensory and motor cortices, 28 Han and colleagues found increased within-module FC, but decreased inter-module FC, 33 and Vakhtin and colleagues found decreased FC among various brain networks (default mode network [DMN]-basal ganglia, attention-sensorimotor, frontal-DMN, attentionfrontal, and sensorimotor-sensorimotor).…”

Section: Introductionmentioning

confidence: 99%

Resting-State Magnetoencephalography Reveals Different Patterns of Aberrant Functional Connectivity in Combat-Related Mild Traumatic Brain Injury

Huang

Harrington

Swan

et al. 2017

Journal of Neurotrauma

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Blast mild traumatic brain injury (mTBI) is a leading cause of sustained impairment in military service members and veterans. However, the mechanism of persistent disability is not fully understood. The present study investigated disturbances in brain functioning in mTBI participants using a source-imaging-based approach to analyze functional connectivity (FC) from resting-state magnetoencephalography (rs-MEG). Study participants included 26 active-duty service members or veterans who had blast mTBI with persistent post-concussive symptoms, and 22 healthy control active-duty service members or veterans. The source time courses from regions of interest (ROIs) were used to compute ROI to whole-brain (ROI-global) FC for different frequency bands using two different measures: 1) time-lagged cross-correlation and 2) phase-lock synchrony. Compared with the controls, blast mTBI participants showed increased ROI-global FC in beta, gamma, and low-frequency bands, but not in the alpha band. Sources of abnormally increased FC included the: 1) prefrontal cortex (right ventromedial prefrontal cortex [vmPFC], right rostral anterior cingulate cortex [rACC]), and left ventrolateral and dorsolateral prefrontal cortex; 2) medial temporal lobe (bilateral parahippocampus, hippocampus, and amygdala); and 3) right putamen and cerebellum. In contrast, the blast mTBI group also showed decreased FC of the right frontal pole. Group differences were highly consistent across the two different FC measures. FC of the left ventrolateral prefrontal cortex correlated with executive functioning and processing speed in mTBI participants. Altogether, our findings of increased and decreased regionalpatterns of FC suggest that disturbances in intrinsic brain connectivity may be the result of multiple mechanisms, and are associated with cognitive sequelae of the injury.

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“…Otras áreas generales como el cuerpo calloso, siembras grandes en el tallo cerebral, en el tálamo, los lóbulos frontales/temporales y en los tractos largos como el tracto corticoespinal han sido usadas para evaluar estos valores en DWI (35,36,38), siguiendo las recomendaciones para el mapeo general del cerebro con el reciente estudio americano Connectome, que pretende establecer las conexiones cerebrales existentes, y que ha servido de soporte para diferentes estudios en pacientes con trauma craneoencefálico (39)(40)(41).…”

Section: Discussionunclassified