Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder

Ajilore, Olusola; Vizueta, Nathalie; Walshaw, Patricia D.; Zhan, Liang; Leow, Alex D.; Altshuler, Lori L.

doi:10.1016/j.jpsychires.2015.05.017

Cited by 58 publications

(20 citation statements)

References 51 publications

(59 reference statements)

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“…56,57 Additionally, several studies have reported that the ventral prefrontal cortex is implicated in the "top-down" regulation of emotional processing in patients with BD. 58,59 The FA reduction in the genu of the corpus callosum in the present study suggests impaired prefrontal interhemispheric connectivity, perhaps leading to neurocognitive deficits in processing speed and working memory, 60 for example, and to emotional dysregulation in patients with BD. Our subgroup analysis of patients with BD I reproduced the finding of decreased FA in the genu of corpus callosum compared with healthy controls, which was consistent with the findings of some previous DTI studies.…”

Section: Discussionmentioning

confidence: 63%

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Yang

Luo

et al. 2019

jpn

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Background: An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder. Methods: We conducted a systematic search up to May 2017 for all TBSS studies comparing fractional anisotropy (FA) between patients with bipolar disorder and healthy controls. We performed anisotropic effect size-signed differential mapping meta-analysis. Results: We identified a total of 22 data sets including 556 patients with bipolar disorder and 623 healthy controls. We found significant FA reductions in the genu and body of the corpus callosum in patients with bipolar disorder relative to healthy controls. No regions of increased FA were reported. In subgroup analyses, the FA reduction in the genu of the corpus callosum retained significance in patients with bipolar disorder type I, and the FA reduction in the body of the corpus callosum retained significance in euthymic patients with bipolar disorder. Meta-regression analysis revealed that the percentage of female patients was negatively correlated with reduced FA in the body of the corpus callosum. Limitations: Data acquisition, patient characteristics and clinical variables in the included studies were heterogeneous. The small number of diffusion tensor imaging studies using TBSS in patients with bipolar disorder type II, as well as the lack of other clinical information, hindered the application of subgroup meta-analyses. Conclusion: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder.

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Section: Discussionmentioning

confidence: 63%

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Yang

Luo

et al. 2019

jpn

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“…Studies investigating the neuropsychological effects of WM abnormalities have consistently demonstrated an association between widespread reductions in FA and slower PS in both HC (32,33) and BD samples (34). Thus, the relationship between reduced right UF FA and slower PS seen in the present study is consistent with an expected neuropsychological outcome of WM pathology.…”

Section: Discussionmentioning

confidence: 99%

Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder

Dev

Nguyen

McKenna

et al. 2017

The American Journal of Geriatric Psychiatry

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Objectives Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). However, few studies have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy comparison (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging. Design Cross-sectional study. Setting University of California San Diego and the Veterans Administration San Diego Healthcare System. Participants 33 euthymic BD and 38 HC participants. Measurements Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test. Results BD participants demonstrated slower PS compared to the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently. Conclusions Results provide support toward future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.

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“…These structural deficits suggest a potential etiology for frontally-mediated functional deficits seen in prior fMRI studies of bipolar disorder (7) and could explain why IFC functional deficits, in particular, appear trait- rather than state-related. That is, IFC hypoactivation has been reported both in bipolar mania (67, 68) and euthymia (18, 19, 50). Further, prior work shows patients with focal lesions to BA 6 have an increased number of false alarms during a simple Go-NoGo task (65) suggesting that structural abnormalities in this region impair performance.…”

Section: Discussionmentioning

confidence: 99%

“…A well-validated response inhibition task (Go-NoGo) (50) was used to probe brain regions involved in cognitive control, including IFC, other OFC regions (BA 10, 11, 47) and the cingulate (BA 24/32). Task details have been published previously (50) and are illustrated in Figure 1A and presented in the Supplement.…”

Section: Methodsmentioning

confidence: 99%

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Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder

Joshi

Vizueta

Foland‐Ross

et al. 2016

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Performance during cognitive control functional magnetic resonance imaging (fMRI) tasks are associated with frontal lobe hypoactivation in patients with bipolar disorder, even while euthymic. Here, we study the structural underpinnings for this functional abnormality simultaneously with brain activation data. Methods In a sample of ninety adults (45 with inter-episode Bipolar I disorder and 45 healthy controls), we explored whether abnormal functional activation patterns in bipolar euthymic subjects during a Go-NoGo fMRI task are associated with regional deficits in cortical gray matter thickness in the same regions. Cross-sectional differences in fMRI activation were used to form a-priori hypotheses for region-of-interest cortical gray matter thickness analyses. fMRI BOLD to structural magnetic resonance imaging (sMRI) thickness correlations were conducted across the sample and within patients and controls separately. Results During response inhibition (NoGo minus Go), bipolar subjects showed significant hypoactivation and reduced thickness in the inferior frontal cortex (IFC), superior frontal gyrus and cingulate compared to controls. Cingulate hypoactivation corresponded with reduced regional thickness. A significant activation by disease state interaction was observed with thickness in left prefrontal areas. Conclusions Reduced cingulate fMRI activation is associated with reduced cortical thickness. In the left frontal lobe, a thinner cortex was associated with increased fMRI activation in patients, but showed a reverse trend in controls. These findings suggest that reduced activation in the IFC and cingulate during a response inhibition task may have an underlying structural etiology, which may explain task-related functional hypoactivation that persists even when patients are euthymic.

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Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder

Cited by 58 publications

References 51 publications

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder

Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder

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