Connector-Free World-to-Chip Interconnection for Microfluidic Devices

Abstract

In the development of functional lab-on-a-chip (LOC), there is a need to produce a reliable and high pressure connection between capillary tubes and microfluidic devices for carrying fluids. The current technologies still have limitations in achieving ideal interconnection since they are bulky, expensive or complicated. In this paper, a novel connector-free technique using an interference fit mechanism is introduced for world-to-chip interconnection. The proposed technique has considerable potential for replacing current interconnection tools for microfluidic devices due to the advantages including no chemical contamination, easy plugging, enough strength to sustain pressure, high density integration, simple and rapid integration.

Development of an on-chip sample injection system with a 6-port valve incorporated in a microchip

“…To decrease the dead volume at the tubing connections between the microchip and the outside macro-world, some researchers have developed uidic interconnection techniques, such as a ball-joint connection, 18 an interference t connection, 19,20 and connections using a convex-type or a long cast ange shaped polydimethylsiloxane (PDMS). 21,22 Further, van Swaay et al 23 developed a simple and inexpensive chip-to-world connector with a sample injection port.…”

Advanced microfluidic devices for fabricating multi‐structural hydrogel microsphere

“…The stability of the device during the bonding process is another issue that cannot be neglected, as most thermoplastic devices are deformed by significant changes in Young's modulus during the bonding process. [43]…”

Universal and Versatile Magnetic Connectors for Microfluidic Devices

“…They can be reused but involve additional manipulation, such as dissolving glue with acetone. Alternatively, integrated interference fits, or miniature sockets can sustain high pressures but require specialized tooling and precision machining [ 14 , 15 ]. By contrast, other investigators have used magnetic clamping to connect reconfigurable microfluidic modules [ 16 , 17 , 18 ].…”