2018
DOI: 10.3390/ijms19071891
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Connexin 43 Plays a Role in Pulmonary Vascular Reactivity in Mice

Abstract: Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1). Connexin (Cx)43 has been shown to be involved in cellular communication within the pulmonary vasculature. Therefore, we investigated the role of Cx43 in pulmonary vascular reactivity using Cx43 heterozygous (Cx43+/−) mice and 37,43Gap27, which is a pharmacological inhibitor of Cx37 and Cx43. Contraction and relaxation responses were… Show more

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Cited by 16 publications
(16 citation statements)
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“…PA vasoreactivity to ET-1 was increased in Cx43 +/− mice compared to Cx43 +/+ mice, under both N and CH conditions (figure 6a), whereas PA vasoreactivity to 5-HT was identical in all groups of mice (figure 6b). Such results are consistent with those observed by HTET et al [11] in Cx43 +/− C57BL6 mice. Such a role for Cx43 on PA vasoreactivity to ET-1 may explain why, despite PA remodelling and inflammation being absent, right-ventricular systolic pressure and Fulton index remained high in Cx43 +/− mice with CH-PH compared to Cx43 +/+ mice with CH-PH.…”
Section: Discussionsupporting
confidence: 94%
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“…PA vasoreactivity to ET-1 was increased in Cx43 +/− mice compared to Cx43 +/+ mice, under both N and CH conditions (figure 6a), whereas PA vasoreactivity to 5-HT was identical in all groups of mice (figure 6b). Such results are consistent with those observed by HTET et al [11] in Cx43 +/− C57BL6 mice. Such a role for Cx43 on PA vasoreactivity to ET-1 may explain why, despite PA remodelling and inflammation being absent, right-ventricular systolic pressure and Fulton index remained high in Cx43 +/− mice with CH-PH compared to Cx43 +/+ mice with CH-PH.…”
Section: Discussionsupporting
confidence: 94%
“…Collectively, these results indicate that Cx43 plays an important role in PA vasoreactivity, under both physiological and pathophysiological conditions (N and CH-PH, respectively), as already shown in rat and C57BL6 mouse pulmonary circulation [7,8,11].…”
Section: Discussionsupporting
confidence: 79%
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“…10 Mice deficient in Cx43 show reduced pulmonary vascular relaxation, and pharmacological inhibition of Cx43 also reduces pulmonary vascular relaxation. 11 In addition, Cx43 can mediate 5-HT signalling between rat PAECs and rat PASMCs (rPASMCs). 12 Transfer of 5-HT between these cell types was inhibited by the non-specific gap junction blocker, carbenoxolone or by siRNA knockdown of Cx43, but not by the serotonin transporter inhibitor fluoxetine.…”
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confidence: 99%