Connexines et canaux jonctionnels. Leurs rôles dans la propagation de l’activité électrique cardiaque et le développement du cœur

Expression level, control, and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of four male and four female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins, cadherins, plakophilins, and other components of the intercalated discs form a complex network that is chamber dependent and differs between the two sexes. In addition, most HRD genes in atria had higher expression in males than in females, while in ventricles, expression levels were mostly higher in females than in males. Moreover, significant chamber differences were observed between the sexes, with higher expression in atria than ventricles for males and higher expression in ventricles than atria for females. We have ranked the selected genes according to their prominence (new concept) within the HRD gene web defined as extent of expression coordination with the other web genes and stability of expression. Interestingly, the prominence hierarchy was substantially different between the two sexes. Taken together, these findings indicate that the organizational principles of the heart rhythm transcriptome are sex dependent, with the newly introduced prominence analysis allowing identification of genes that are pivotal for the sexual dichotomy.

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Sex-dependent gene regulatory networks of the heart rhythm

Iacobaş

Thomas

et al. 2009

Funct Integr Genomics

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La communication intercellulaire par l’intermédiaire des jonctions gap : un nouveau mécanisme dans la physiopathologie de la migraine avec aura. Applications thérapeutiques

Sarrouilhe

Dejean

2012

Pathologie Biologie

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Connexines et conduction cardiaque

Hervé

Derangeon

2013

Archives des Maladies du Coeur et des Vaisseaux - Pratique

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Connexines et canaux jonctionnels. Leurs rôles dans la propagation de l’activité électrique cardiaque et le développement du cœur

Cited by 6 publications

References 37 publications

Sex-dependent gene regulatory networks of the heart rhythm

Sex-dependent gene regulatory networks of the heart rhythm

La communication intercellulaire par l’intermédiaire des jonctions gap : un nouveau mécanisme dans la physiopathologie de la migraine avec aura. Applications thérapeutiques

Connexines et conduction cardiaque

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