Abstract. In this paper we prove that if the r-th tensor power of the tangent bundle of a smooth projective variety X contains the determinant of an ample vector bundle of rank at least r, then X is isomorphic either to a projective space or to a smooth quadric hypersurface. Our result generalizes Mori's, Wahl's, Andreatta-Wiśniewski's and Araujo-Druel-Kovács's characterizations of projective spaces and hyperquadrics.Key words. Algebraic geometry, rational varieties, projective spaces, quadric hypersurfaces.AMS subject classifications. 14M20.1. Introduction. Starting with Mori's seminal paper [Mor79] where the author characterized projective spaces as the only smooth projective varieties with ample tangent bundle, the study of the relation of the positivity of the tangent bundle with the geometry of the variety has become a very active subject in the classification theory of smooth projective variety.In [CS95], the authors prove that if X is a smooth complex projective variety of dimension 3 with ∧ 2 T X ample, then X is isomorphic to a projective space or an hyperquadric.The aim of this paper is to provide a new characterization of projective spaces and hyperquadrics in terms of positivity properties of the tangent bundle. We refer the reader to the article [ADK08] which reviews these matters. Notice that our results generalize Mori's (see