Connotation of Glutathione-S-Transferase Enzyme Expression (GST) and Glutathione (GSH) in Human Head and Neck Squamous Cell Carcinoma Cancer

Abstract

Introduction: A series of enzymes deliver protection from harmful injury by toxic chemicals. Among these, Glutathione-S-transferase (GST) is most imperative for detoxifying exogenous and endogenous substances to protect cells from the toxic effects of ROS. Reactive oxygen free radicals are implicated in the pathogenesis of a multistage process of head and neck carcinogenesis, which are proposed to cause DNA base alterations, strand breaks, damage to tumor suppressor genes and an enhanced expression of proto-oncogenes.