Conotoxins down under

Norton, Raymond S.; Olivera, Baldomero M.

doi:10.1016/j.toxicon.2006.07.022

Cited by 155 publications

(157 citation statements)

References 172 publications

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“…Первые конотоксины, взаимодействующие с калиевыми каналами, были обнаружены и охарактеризованы в 1996 году [80], и на данный момент незначительное их число изучено подробно. Исследование молекулярных механизмов взаимодействия конотоксинов, связывающихся с гетеромерными К-каналами, требует значительных усилий: из-за сложной структуры канала затруднительно точно определить молекулярную мишень конотоксина [25].…”

Section: Mо-конотоксины и D-конотоксиныunclassified

“…Физиологически k-PVIIA действует синергично с d-конотоксином РVIA, приводя к общему перевозбуждению мембран электрочувствительных клеток всего организма жертвы и её почти мгновенному тетаническому параличу [25].…”

Section: Mо-конотоксины и D-конотоксиныunclassified

“…kА-и kМ-конотоксины значительно различаются по строению. kА-Конотоксины представляют собой О-гликозилированные олигопептиды, относящиеся к А-надсемейству [25], тогда как kМ-конотоксины относятся с М-надсемейству и по паттерну дисульфидных связей близки к m-конотоксинам [81].…”

Section: 32unclassified

“…С химической точки зрения токсины конусов (в широком смысле -конопептиды) представляют собой олигопептиды длиной 12-46 аминокислотных остатков (а.о. ), как правило, содержащие большое число остатков цистеина [25,26]. Количество и порядок расположения остатков цистеина лежит в основе химической классификации конотоксинов (рисунок).…”

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Conotoxins: from the biodiversity of gastropods to new drugs

et al. 2013

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A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970 . There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.

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Section: Mо-конотоксины и D-конотоксиныunclassified

Section: 32unclassified

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Conotoxins: from the biodiversity of gastropods to new drugs

et al. 2013

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“…By far, the most extensively studied toxoglossate gastropods are the cone snails that belong to the Conidae family (20,28,29). Modern Conus research has primarily focused on purifying and characterizing the toxins from the venom apparatus and on demonstrating that the poison from an individual cone snail contains several toxins, mostly small peptides (conotoxins) that target specific isoforms of receptors or ion channels (3,6,20,25,27,35). While Conidae venoms have been widely investigated, there have been only two studies concerning biochemical characterization of toxoglossate venoms other than those of cone snails (17,21).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of venoms obtained from Mexican toxoglossate gastropods on isolated guinea pig ileum

Rojas¹,

Feregrino²,

Ibarra-Alvarado³

et al. 2008

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The protein-containing extracts prepared from the venom ducts of Conus austini, Conus spurius and Polystira albida caused a concentration-dependent inhibition of spontaneous contractions in guinea pig ileum. The most potent extract was obtained from P. albida venom ducts (IC 50 = 0.11 ± 0.02 µg protein/mL). The three extracts produced a moderate inhibition of contractions elicited by acetylcholine (ACh 1 µM), suggesting the presence of anticholinergic compounds. The contractile response elicited by nicotine (10 µM) was significantly reduced by the extracts prepared from the ducts of C. austini and P. albida, which indicates that the venom produced by these species contains toxins that target neuronal nicotinic receptors. All three extracts significantly inhibited contractions evoked by histamine (0.5 µM), particularly those from C. spurius and P. albida. These findings reveal the presence of antihistaminergic compounds not previously described in any conoidean venom. Finally, we found that only the extract prepared from C. spurius ducts decreased KCl (60 mM)-induced contractions, indicating that the venom of this snail contains compounds that block voltage-dependent Ca 2+ or Na + channels.

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Peptides

Döhren

2010

Encyclopedia of Industrial Biotechnology

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Conotoxins down under

Cited by 155 publications

References 172 publications

Conotoxins: from the biodiversity of gastropods to new drugs

Conotoxins: from the biodiversity of gastropods to new drugs

Pharmacological characterization of venoms obtained from Mexican toxoglossate gastropods on isolated guinea pig ileum

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