Consanguineous marriages in Beirut: Time trends, spatial distribution

Khlat, Myriam

doi:10.1080/19485565.1988.9988710

Cited by 36 publications

(35 citation statements)

References 12 publications

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“…Based on the assumption that 25% of marriages occur between first cousins, F was found to be equal to 1.56%. [22][23][24] Under the same assumption, the ROH method and FEstim estimated F equal to 2.3 and 2.6%, respectively; these values are significantly higher than what was previously found (1.56%). Therefore, these genome-wide findings lead to the inclusion of Lebanon in the group of Middle Eastern countries that show high levels of inbreeding.…”

Section: Discussionmentioning

confidence: 48%

“…Under the assumption that 25% of the unions in Lebanon are between first cousins, HBD values (Table 1) lead to an estimated F mean value equal to 2.3%, a much higher percentage than the previously estimated (1.56%). 3,[23][24][25] Homozygosity estimation using FEstim Among the 90 individuals, 48 had an inbreeding coefficient F significantly different than zero (Figure 2). In fact, we found that 33 of 34 FCO individuals and 14 of 55 (25%) URO individuals were inbred.…”

Section: Distribution Of Roh Regions Between Lebanese Communities Andmentioning

confidence: 99%

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Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

et al. 2014

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Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In consanguineous marriages, parents pass to their children autozygous segments known as homozygous by descent segments. In this study, single-nucleotide polymorphisms were analyzed in 165 unrelated Lebanese people from Greek Orthodox, Maronite, Shiite and Sunni communities. Runs of homozygosity, total inbreeding levels, remote consanguinity, and population admixture and structure were estimated. The inbreeding coefficient value was estimated to be 1.61% in offspring of unrelated parents over three generations and 8.33% in offspring of first cousins. From these values, remote consanguinity values, resulting from genetic drift or recurrent consanguineous unions, were estimated in offspring of unrelated and first-cousin parents to be 0.61 and 1.2%, respectively. This remote consanguinity value suggests that for any unrelated marriages in Lebanon, the mates could be related as third cousins or as second cousins once removed. Under the assumption that 25% of marriages occur between first cousins, the mean inbreeding value of 2.3% may explain the increased incidence of recessive disease in offspring. Our analysis reveals a common ancestral population in the four Lebanese communities we studied.

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Section: Discussionmentioning

confidence: 48%

Section: Distribution Of Roh Regions Between Lebanese Communities Andmentioning

confidence: 99%

Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

et al. 2014

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“…Only the hus band's education and his parents' consan guinity status were found to be significant variables. In other studies [11,[32][33][34][35], people in the lower social strata were more likely to practise endogamy than those in the upper strata of society, an example being the Pakis tanis in Britain who are associated with poor health indicators [36], but practise endogamy even at higher rates than those in Pakistan. However, in another study [29] from Bir mingham, social class and demographic fea tures were not found to contribute to the inci dence of consanguinity.…”

Section: Discussionmentioning

confidence: 99%

Consanguinity and Associated Socio-Demographic Factors in the United Arab Emirates

et al. 1996

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The aim of this study was to explore the association between socio-demographic factors and consanguineous marriages in the United Arab Emirates (UAE). This was a cross-sectional population-based study conducted in the cities of Al Ain and Dubai between October 1994 and March 1995. A multi-stage sampling design was used and a representative total sample of 2,200 UAE females aged 15 years and above were included in this study. Data on 2,033 (85.8%) UAE national families who consented to participate in the study were obtained. The rate of consanguineous marriages in the sample was found to be 50.5% with 95% estimated population confidence limits 49.2–51.8%. The socio-demographic factors considered were: husband’s age, wife’s age, husband’s and wife’s educational levels, husband’s occupation, wife’s occupation, housing conditions, husband’s parental kinship, wife’s parental kinship, and kinship between the spouses. Consanguinity is more common among women with educated husbands (secondary or university/high) than among women with less educated husbands. The results indicate that the frequency of consanguineous marriages significantly increases when the husband’s educational level is higher (p = 0.003). The distribution of relationship between spouses over the two generations of the study group and their parents is presented. The incidence of consanguineous marriages among the parents is 53% and 62% for the women and their husbands, respectively, and the overall incidence is 57%. The parallel patrilateral marriage is obviously the favoured practice when considering the parent’s kinship distributions. The results of step-wise multiple logistic regression analysis for the occurrence of consanguineous marriages show that the husband’s education and husband’s parents’ consanguinity status only are significantly associated variables.

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“…[1][2][3][4][5][6][7][8][9][10][11][12] Consanguinity has a significant influence on child mortality and morbidity independent of other causes of death and disease. '3'14 Previous studies of mainly nonconsanguineous parents have found that once stillbirth or infant death has appeared in a family, the risk of recurrence in subsequent siblings is higher than the population risk.…”

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confidence: 99%

Consanguinity and recurrence risk of stillbirth and infant death.

Stoltenberg¹,

Magnus²,

Skrondal³

et al. 1999

Am J Public Health

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OBJECTIVES: The aim of this study was to estimate the recurrence risk for stillbirth and infant death and compare results for offspring of first-cousin parents with results for offspring of unrelated parents. METHODS: The study population consisted of all single births with a previous sibling born in Norway between 1967 and 1994. Altogether, 629,888 births were to unrelated parents, and 3466 births were to parents who were first cousins. The risk of stillbirth and infant death was estimated for subsequent siblings contingent on parental consanguinity and survival of the previous sibling. RESULTS: For unrelated parents, the risk of early death (stillbirth plus infant death) for the subsequent sibling was 17 of 1000 if the previous child survived and 67 of 1000 if the previous child died before 1 year of age. For parents who were first cousins, the risk of early death for the subsequent sibling was 29 of 1000 if the previous child survived and 116 of 1000 if the previous child died. CONCLUSIONS: The risk of recurrence of stillbirth and infant death is higher for offspring of first-cousin parents compared with offspring of unrelated parents.

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Consanguineous marriages in Beirut: Time trends, spatial distribution

Cited by 36 publications

References 12 publications

Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

Consanguinity and Associated Socio-Demographic Factors in the United Arab Emirates

Consanguinity and recurrence risk of stillbirth and infant death.

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