Consanguineous Marriages in the Middle East: Nature Versus Nurture

Bowirrat, Abdalla; Zaher, Armaly

doi:10.2174/1876391x01305010001

Cited by 19 publications

(11 citation statements)

References 74 publications

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“…Results are illustrated in Additional file 2: Figure S5. We found ROH16 to be significantly greater than IBD16 for the Nepalese Indo-Aryan supporting consanguinity as an explanation for observed ROH patterns in that population, despite unions between biological kin being prohibited [27]. Although ROH16 was also greater than the IBD16 for all other Nepalese ethnic groups tested, the results were not significant.…”

Section: Resultsmentioning

confidence: 63%

Genetic structure in the Sherpa and neighboring Nepalese populations

et al. 2017

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BackgroundWe set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity.ResultsWe identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry.ConclusionsWe show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3469-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 63%

Genetic structure in the Sherpa and neighboring Nepalese populations

et al. 2017

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“…In Kuwait, similar to other Arab countries, the prevalence of consanguineous marriages is high and it reached 54.3% [7]. Consequently, this leads to an increased incidence of autosomal recessive disorders some of which are rare and lethal [8,9]. In this report, pedigree analysis revealed that the concerned family had practiced consanguinity over many generations, and with many first cousin couples (Fig.…”

Section: Discussionmentioning

confidence: 53%

Primary ciliary dyskinesia: Kartagener syndrome in a family with a novel DNAH5 gene mutation and variable phenotypes

Marafie

Suliman

Redha

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: Primary ciliary dyskinesia is a genetically heterogeneous autosomal recessive disorder with variable clinical manifestations, including chronic rhinosinusitis, otitis media, bronchitis, pneumonia, bronchiectasis, situs inversus totalis, reduced fertility in female patients and male infertility. The condition occurs as a result of abnormal ciliary structure and function. It is presented in early life with an estimated incidence of approximately 1/16,000-20,000. About 50% of the affected patients have situs inversus totalis leading to Kartagener syndrome (MIM: 244400). So far more than 19 causative genes have been associated with primary ciliary dyskinesia.Case report: Here we are presenting Kartagener syndrome in a consanguineous Kuwaiti family with a novel pathogenic DNAH5 gene mutation; namely c.9864dupA; [p.Pro3289ThrfsStop52], which is predicted to result in protein truncation. In this family several homozygous individuals showed variable disease manifestations.Conclusion: Molecular test helped in confirmation of the clinical diagnosis and in providing better management of the affected family members, which in turn could significantly improve overall quality of their life. Consequently, preimplantation genetic diagnosis, which is the most acceptable procedure in the Islamic countries, was offered to the heterozygous-carrier couple in order to prevent recurrence of the disease in their future generations.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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“…The highest prevalence is in Oman (56%) followed by Sudan, Libya, UAE, and Saudi Arabia, where 40-50% of spouses are married to their first cousins. In Algeria, Egypt, Jordan, and Kuwait, the prevalence ranges from 20% to 30%, while in the remaining countries the rate is under 20% (Jurdi and Saxena 2002;DeJong et al 2005;Tadmouri et al 2009;Abdalla and Zaher 2013).…”

Section: Marriage Patternsmentioning

confidence: 99%

Reproductive Health in Arab Countries

Abdelbaqy

2019

Handbook of Healthcare in the Arab World

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Reproductive health in the Arab region is of great local interest. Traditions and local cultures with the differences in healthcare policies help to shape services available in the region. This chapter reviews healthcare services in different Arab countries, with a focus on the general situation in the Arab region and a comparison between various Arab countries. The topics covered include the types of services and accessibility, family planning, female genital mutilation, maternal healthcare services, fertility services, cesarean section, abortion, adolescence health, marriage pattern, reproductive healthcare for refugees, financing sexual and reproductive health (SRH), reproductive cancers, and genetic and congenital anomalies. In general, the lack of awareness and poor resource availability negatively affect women in the region, particularly related to their reproductive health and rights.

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Consanguineous Marriages in the Middle East: Nature Versus Nurture

Cited by 19 publications

References 74 publications

Genetic structure in the Sherpa and neighboring Nepalese populations

Genetic structure in the Sherpa and neighboring Nepalese populations

Primary ciliary dyskinesia: Kartagener syndrome in a family with a novel DNAH5 gene mutation and variable phenotypes

Reproductive Health in Arab Countries

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