Consanguineous marriages profile in the Tanger-Tetouan region in Morocco

Hardouz, H; Hami, Hinde; Mokhtari, Abdelrhani; Soulaymani, Abdelmajid; Sbai, L; kheddam, S. El; Doukkali, Z; Quyou, A.

doi:10.9790/3008-09626167

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…Larache province was the most affected with a frequency of 2.02% (11/542). This disproportioned distribution between the three provinces could be explained by the different consanguinity rates, different history with malaria, and disparity in terms of the availability of primary care services and genetic counseling [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of the α -mutated genes is believed to be increased due to the country's socioeconomic and cultural system encouraging consanguinity, the selective pressure of malaria in endemic close countries, and its history as a migration crossroad between sub-Saharan Africa and Europe [ 9 , 10 ]. The World Health Organization estimates the rate of hemoglobinopathies carriers in Morocco at 6.5%, with more than 30 000 cases of major forms [ 11 ]. A previous regional study highlighted the region of North Morocco as a geographical hot-spot for hemoglobinopathies due to its high consanguinity rate already estimated and its location in the malaria belt [ 10 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Laghmich

Ismaili

Barakat

et al. 2019

BioMed Research International

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Unlike the other hemoglobinopathies, few researches have been published concerning α-thalassemia in Morocco. The epidemiological features and the mutation spectrum of this disease are still unknown. This regional newborn screening is the first to study α-thalassemia in the north of Morocco. During the period from January 2015 to December 2016, 1658 newborns umbilical blood samples were investigated. Suspected newborns were screened for α-globin defects using Gap-PCR and Multiplex Ligation-dependent Probe Amplification technique. The prevalence of α-thalassemia, its mutation spectrum, and its allelic frequencies were described for the first time in Morocco. Six different α-globin genetic disorders were detected in 16 neonates. This screening valued the prevalence of α-thalassemia in the studied population at 0.96% and showed the wide mutation spectrum and the heterogeneous geographical distribution of the disease. A high rate of carriers was observed in Laouamra, a rural commune in Larache province. Heterogeneity of α-globin alleles in Morocco explains the high variability of α-thalassemia severity. This diversity reflects the anthropological history of the country. These results would contribute to the prevention of thalassemia in Morocco directing the design of a nationwide screening strategy and awareness campaign.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Laghmich

Ismaili

Barakat

et al. 2019

BioMed Research International

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“…Previous works showed that the national consanguinity rate in Morocco varied between 19.81 and 28% [6]. Northern regions registered the highest rates with 39.4% (FI = 0.02033) in the Tangier-Tetouan region [6] and 24.37% (FI = 0.008038) in the Tangier-Tetouan-Al Hoceima region [4]. The Gharb-Chrarda-Beni Hssen region, the neighbor region, also registered a high rate of consanguinity (22.8%) [15].…”

Section: Discussionmentioning

confidence: 99%

“…Regional studies showed that the northern regions register higher inbreeding rates. Recent studies have evaluated consanguinity in the global population of the Tangier-Tetouan region as 39.4% and of the Tangier-Tetouan-Al Hoceima region as 24.37% [5, 6]. Consanguinity in this region seems to be characterized by specific features of socioeconomic, cultural, historical, and geographical order [7].…”

Section: Introductionmentioning

confidence: 99%

Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Laghmich

Ismaili

Zian

et al. 2019

BioMed Research International

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Consanguinity is a social behavior characterized by the arrangement of marriages between relatives. It coincides generally with the geographic distribution of recessive genetic diseases as it increases the likelihood of homozygosis and, consequently, the incidence of their pathologies in the population. In this pilot study, we assess the effect of inbreeding on the burden of hemoglobinopathies in Northern Morocco. From January 2016 to December 2018, 197 children born in the studied region to three ancestral generations and diagnosed with hemoglobinopathies were subject to investigation. The rate of consanguinity in the parents' generation of children with hemoglobinopathies was 50.25%, with first cousin marriages accounting for 68.69% of consanguineous unions (FI = 0.02). The corresponding rates in the general population, based on a sample of N = 900, were 29.67% and 82.02%, respectively. The marriages between first cousins are the most common among the other types of consanguineous unions. Our study propounds that consanguinity substantially contributes to the hemoglobinopathy burden in the studied region and has changed little over time. Refraining from consanguineous marriages and detecting couples at risk could contribute to the reduction of the incidence of genetic diseases in our country.

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“…In the population of northern Morocco, the percentage of consanguineous couples is 24.37%, it is around the national average but is still lower compared to the percentage recorded by a study on the population of Tangier-Tetouan (39%) [20]. 14.86% of consanguineous unions statements, are contracted between spouses whose relationship is undefined (Table 3).…”

Section: Number Of Couplesmentioning

confidence: 95%

Study of consanguinity of the population of northern Morocco

Habibeddine¹,

Ouardani²,

Ossmani³

et al. 2018

J Forensic Res

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Consanguinity is a matrimonial behavior that is much perpetuated in the Arabo-Muslim world. This behavior contributes to the impoverishment of the genetic heritage of populations by increasing the genetic homogeneity, influencing, thus, the state of the public health. Belonging to the Arabo-Muslim world, the North population of Morocco has been partially studied to characterize this matrimonial behavior from an anthropogenetic point of view.Sample of 1588 couples belonging to the population of northern Morocco has been studied. The results showed a level of consanguinity very close to the national average (24.37%). Marriages between first cousins are most widespread among the other types of consanguineous unions (63.18%). Furthermore, specific features seem to characterize the practice of consanguinity in Morocco's northern region, which respond to many socioeconomic, cultural, historical and geographical factors.

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Consanguineous marriages profile in the Tanger-Tetouan region in Morocco

Cited by 5 publications

References 19 publications

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum

Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Study of consanguinity of the population of northern Morocco

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