Consanguinity and associated perinatal outcomes, including stillbirth

Kapurubandara, Supuni; Melov, Sarah J.; Shalou, Evangeline; Alahakoon, I.

doi:10.1111/ajo.12493

Cited by 16 publications

(19 citation statements)

References 23 publications

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“…Congenital abnormalities are a major cause of infant mortality in higher resource environments, with variation between ethnic groups and a strong association with consanguinity [63,64]. Reducing the risks for life-threatening congenital abnormalities [65] (either through the condition itself, or through its association with preterm birth) is dependent on parental awareness regarding the risks of congenital abnormality pre-conceptually, availability and uptake of screening for major congenital abnormalities, the potential for intervention, and parent perspectives on termination of pregnancy, should they carry a baby with a lethal/potentially lethal condition in utero.…”

Section: Reducing the Risks For Congenital Abnormalitiesmentioning

confidence: 99%

Parent-Carer Education: Reducing the Risks for Neonatal and Infant Mortality

Pillay¹

2019

Neonatal Medicine

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In this chapter, the role of engaging parents, family members, partners, significant others and carers (subsequently referred to as parent-carers) as key partners in targeted strategies for reducing the risks associated with neonatal mortality is discussed, especially within the context of less resource-constrained environments. Parent-carer education, sharing information on regionally prevalent risk factors and associations with death in the first 28 days of life and in infancy, can be potentially impactful and could drive behavioural changes, while promoting acquisition of newer life-saving skills such as basic life support training. Such education can be considered participatory learning and action. It affords parent-carers the confidence and knowledge on measures to key risks in infancy, such as the risk of sudden infant death, and how to recognize when their baby may be ill, facilitating timely access to appropriate healthcare services. Potentially, these then empower parent-carers to work with health services proactively in measures to reduce the risks for neonatal mortality.mortality is explored, especially in less resource-constrained environments, by focusing on parent-carer education around risks for neonatal mortality, while using learning points from around the world. Potentially, these initiatives empower parent-carers to acquire the necessary skills to manage their baby at risk and also engage in risk-reducing behaviours for the benefit of their baby. Reducing neonatal mortality through parent-carer educationBefore embarking on parent education, understanding the risk factors for neonatal mortality is important. In poorly resourced areas, key risk factors and associations are infection, hypothermia, lack of breastfeeding, failure to recognise signs of illness in their baby and failure to provide adequate basic resuscitation at birth. Education packages focused on improving neonatal mortality therefore include information on maintaining warmth; drying; wrapping; skin-to-skin contact; supporting breastfeeding; infection prevention including handwashing, cord care, recognising signs of illness in their newborn baby and infant and basic life support [7].For neonatal teams in relatively higher resourced environments, where access to public health facilities and general maternal education are less of an issue, and most of the above are routinely adopted, what are other key risk factors and what other kinds of initiatives are needed in order to make a difference to current neonatal mortality rates, and can they work?In attempting to address this, the key risk factors here for neonatal mortality need to be identified. The most significant of these is prematurity [8][9][10]. In a report on perinatal mortality from MBRRACE on 2016 deaths, approximately 70% of all extended perinatal deaths occurred preterm, and almost 40% were in less than 28 weeks' gestation [9]. Optimising place of birth for the most vulnerable preterm births less than 26 weeks gestation at birth does reduce their mortality rates [11] and op...

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Section: Reducing the Risks For Congenital Abnormalitiesmentioning

confidence: 99%

Parent-Carer Education: Reducing the Risks for Neonatal and Infant Mortality

Pillay¹

2019

Neonatal Medicine

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“…conducted in Australia, where the consanguinity rate is 5.5%, concluded that parental consanguinity was associated with higher rates of threatened premature labour, fetal congenital abnormality, stillbirth, and perinatal mortality. 5 In that study, consanguinity was also found to be an independent risk factor of nearly 3-fold for stillbirth. In Hong Kong, parental consanguinity is more frequent among non-Chinese ethnic minorities, which account for 8% of the total population.…”

Section: Implications For Clinical Practice or Policymentioning

confidence: 83%

“…Most previous studies have not evaluated the effects of closer consanguinity that might increase risks of hereditary disorders. 5,15,16 To evaluate the effect of degree of inbreeding, comparisons were made among 'first cousin or closer' (including first cousin and double first cousin), 'beyond first cousin' (including first cousin once removed and second cousin), and non-consanguineous relationships.…”

Section: Fig Family Trees Of Consanguineous Marriages With Corresponmentioning

confidence: 99%

Parental consanguinity in Hong Kong

2019

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Enantioselective syntheses Enantioselective syntheses O 0031Catalytic Asymmetric Epoxidation of Alkenes with Arabinose-Derived Uloses.-Four L-erythro-2-uloses such as (I) are prepared and applied as catalysts in the epoxidation of trans-stilbene using Oxone as oxidant. Compounds (I) exhibit good enantioselectivities (up to 90% e.e.) but give only poor yields due to decomposition of the uloses during the reaction. Three L-threo-3-uloses such as (II) are not decomposed under epoxidation conditions and higher yields but lower enantioselectivities are obtained. (II) give moderate enantioselectivities and good yields in epoxidations of di-and trisubstituted alkenes.

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“…Another Indian study reported 26.9% of women having history of consanguineous marriage, while the current study reported it to be 19%. Consanguinity is associated with adverse perinatal outcome, pregnancy loss, stillbirths and low birth weight babies [33].…”

Section: Discussionmentioning

confidence: 99%

Health risks among women desiring pregnancy within one year: a cross-sectional study in Maharashtra India

Gothankar

Doke

Palkar

et al. 2020

Preprint

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Background Health of women during preconception phase though critical is comparatively ignored period in her life cycle. Presence of health risks are judged as hazardous to well-being of women and her forthcoming progeny. The objective of the study was to measure the prevalence of health risks and its comparison between blocks.Methods A cross sectional study was conducted in two tribal and two non-tribal blocks in Nasik district, Maharashtra, India. Currently married women desiring conception within one year were included as study participants. Sample size was estimated to be 6,951. Data was collected by trained Accredited Social Health Activists using validated interview schedule. Anthropometric measures of women were recorded in standard manner. Body Mass Index criteria were used to assess the nutritional status.Results Mean age of women was 23.19 ± 3.71 years and 16% of them were adolescents. Illiteracy rate was higher in tribal than non-tribal women. Commonest reported occupation was farming. Despite being high parity and gravida status more tribal women desired pregnancy. Substance abuse was high among tribal women. Majority of women consumed meal with family members or with husband. Although 35% of women had low consumption of protein and calorie, yet most of them perceived to have abundant food.Conclusion Health risks namely younger age, illiteracy, farming with moderate to high-intensity work, high parity, low consumption of protein and calories and undernutrition were found to be prevalent and the risks were significantly more among tribal women. “Continuum of care” must include preconception care.

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Consanguinity and associated perinatal outcomes, including stillbirth

Cited by 16 publications

References 23 publications

Parent-Carer Education: Reducing the Risks for Neonatal and Infant Mortality

Parent-Carer Education: Reducing the Risks for Neonatal and Infant Mortality

Parental consanguinity in Hong Kong

Health risks among women desiring pregnancy within one year: a cross-sectional study in Maharashtra India

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