Consanguinity and family clustering of male factor infertility in Lebanon

Inhorn, Marcia C.; Kobeissi, Loulou; Nassar, Zaher; Lakkis, D.; Fakih, M.H.

doi:10.1016/j.fertnstert.2008.01.008

Cited by 37 publications

(28 citation statements)

References 28 publications

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“…These results are compatible with those of other studies (Khlat et al, 1988a, b;Barbari et al, 2003;Barbour & Salameh, 2009;Inhorn et al, 2009;Mumtaz et al, 2010) and other Arab (Tadmouri et al, 2009;Othman & Saadat, 2009) and Islamic populations (Saadat et al, 2004;Saify & Saadat, 2012), which have all shown high levels of consanguinity. These results are compatible with those of other studies (Khlat et al, 1988a, b;Barbari et al, 2003;Barbour & Salameh, 2009;Inhorn et al, 2009;Mumtaz et al, 2010) and other Arab (Tadmouri et al, 2009;Othman & Saadat, 2009) and Islamic populations (Saadat et al, 2004;Saify & Saadat, 2012), which have all shown high levels of consanguinity.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Consanguineous Marriages Among Shi'a Populations of Lebanon

El-Kheshen

Saadat

2013

J. Biosoc. Sci.

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In genetics, a consanguineous marriage means union between couples who are related as second cousins or closer. The present cross-sectional study was carried out in order to illustrate the prevalence and types of consanguineous marriages in the Shi'a population living in widespread territories in Lebanon including the Bekaa Valley, the south of Lebanon and the southern suburb of Beirut. Data on types of marriages were collected using a simple questionnaire. The total number of couples in the study was 1203. Consanguineous marriage was classified by the degree of relationship between couples. The overall frequency of consanguinity was found to be 28.4%, with first cousin marriages (21.3%) being the most common type followed by first cousins once removed (5.5%), then double first cousins (0.8%). The frequencies of second cousin and beyond second cousin marriages were the same at 0.4% of all the marriages. The mean inbreeding coefficient (α) was estimated at about 0.0161 for the population. There were no significant differences between the three studied territories for frequencies of different types of marriages (p>0.1), nor were there significant differences between the rural and urban areas (p>0.1).

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Section: Discussionsupporting

confidence: 93%

Prevalence of Consanguineous Marriages Among Shi'a Populations of Lebanon

El-Kheshen

Saadat

2013

J. Biosoc. Sci.

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“…Since first cousins co-inherit 12.5% of their genes from a common ancestor, the risk that both carry identical copies of a detrimental geneand therefore the risk of that gene being expressed in their offspringis increased. Medical and genetics research has found that besides early childhood mortality (Bittles et al, 1991;Grant & Bittles, 1997;Khan et al, 1997), consanguinity may be associated with a diverse range of complex disorders, ranging from congenital heart disease (Shieh et al, 2012) to adult-onset conditions such as male infertility (Inhorn et al, 2009), hypertension, myocardial infarction and stroke (Rudan et al, 2003a, b;Ismail et al, 2004), cancers (Rudan et al, 2003a) and schizophrenia (Mansour et al, 2010;Bener et al, 2012). Recent studies suggest that past estimates of the negative health effects of cousin unions have been exaggerated, largely because of inadequate controls for the socioeconomic correlates of such unions (Hamamy et al, 2011;Bittles, 2012).…”

Section: Introductionmentioning

confidence: 99%

Estimating the Health and Socioeconomic Effects of Cousin Marriage in South Asia

et al. 2018

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The effects of marriage between biological relatives on the incidence of childhood genetic illness and mortality are of major policy significance, as rates of consanguinity exceed 50% in various countries. Empirical research on this question is complicated by the fact that consanguinity is often correlated with poverty and other unobserved characteristics of households, which may have independent effects on mortality. This study has developed an instrumental variables empirical strategy to re-examine this question, based on the concept that the availability of unmarried cousins of the opposite gender at the time of marriage creates quasi-random variation in the propensity to marry consanguineously. Using primary data collected in Bangladesh in 2006-07 and Pakistan in 2009-10, the study found that previous estimates of the impact of consanguinity on child health were biased and falsely precise. The study also empirically investigated the social and economic causes of consanguinity (including marital quality) and concludes that marrying a cousin can have positive economic effects for one's natal family, by allowing deferral of dowry payments until after marriage.

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“…Consanguineous marriages are not rare in some countries, beliefs and regions [1][2][3]. In our country, consanguinity among infertile couples and among their parents is not rare.…”

Section: Introductionmentioning

confidence: 69%

Parental Consanguinity in Infertile Males

Demirtaş¹,

Akınsal²,

Ekmekçioğlu³

2013

OJU

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This study was investigated whether parental consanguinity in males has an effect on or relationship with some infertile subgroups and some semen and hormone parameters. The charts of 2651 infertile males were evaluated retrospectively for parental consanguinity ratios, sperm counts, motility parameters and hormonal values from the records of 2651 infertile males. In 1260 eligible males the first cousin parental consanguinity ratio was 22.6%. In 119 males with nonobstructive azoospermic (NOA) and 430 males with normal sperm counts, the ratios were 34.5% and 20.9%, respectively (p = 0.002). In the NOA group the parental consanguinity ratios were 27.1% (23/85) and 52.9% (18/34) in males with FSH values of >7.6 and <7.6 mIU/ml, respectively (p = 0.007). In males with normal sperm counts if the parents were first cousins, both sperm counts and motility parameters were significantly reduced when compared with the others. To our knowledge, this is the first study of consanguinity ratios among some infertile subgroups. In males with parental consanguinity lower sperm counts and motility ratios in normozoospermic males and lower FSH levels in the NOA group might show a relation with some genetically transmitted defects.

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Consanguinity and family clustering of male factor infertility in Lebanon

Cited by 37 publications

References 28 publications

Prevalence of Consanguineous Marriages Among Shi'a Populations of Lebanon

Prevalence of Consanguineous Marriages Among Shi'a Populations of Lebanon

Estimating the Health and Socioeconomic Effects of Cousin Marriage in South Asia

Parental Consanguinity in Infertile Males

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