Consanguinity, prematurity, birth weight and pregnancy loss: a prospective cohort study at four primary health center areas of Karnataka, India

Bellad, Mrutyunjaya; Goudar, Shivaprasad S.; Edlavitch, SA; Mahantshetti, NS; Naik, Vijaya A.; Hemingway-Foday, Jennifer; Gupta, Mrinal; Nalina, HR; Derman, Richard J.; Moss, Nancy; Kodkany, Bhala

doi:10.1038/jp.2011.115

Cited by 27 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their study, PTB was also not increased among consanguineous marriages. Similar findings of a lack of correlation between consanguinity and PTB were also noted in India and Turkey [15][16][17] . However, in these studies the authors did not distinguish between spontaneous and medically induced PTB, and the sample sizes were relatively small.…”

Section: Ptb In Consanguineous Marriagessupporting

confidence: 69%

The Effect of Consanguinity on Neonatal Outcomes and Health

Abbas

Yunis

2014

Hum Hered

View full text Add to dashboard Cite

Consanguineous marriages constitute a significant fraction of marriages worldwide and confer a major public health concern on newborns. In addition to the risk of acquiring a recessive genetic disease, the offspring of consanguineous parents are plausibly at an increased risk of preterm birth, decreased anthropometric measurements, congenital defects and mortality. How consanguinity confers such an increased risk is still largely unknown. In this review, we discuss the effect of consanguinity on selected gestational outcomes by delineating the different studies that have led to such findings. We also investigate the different conclusions that have emerged regarding the effect of consanguinity on gestational outcomes.

show abstract

Section: Ptb In Consanguineous Marriagessupporting

confidence: 69%

The Effect of Consanguinity on Neonatal Outcomes and Health

Abbas

Yunis

2014

Hum Hered

View full text Add to dashboard Cite

show abstract

“…Congenital anomalies represented 8.4% of all causes, with Belagavi, India having a substantially higher proportion (nearly 20%) due to congenital anomalies. A prior study conducted at this site in India found 24% of pregnant women were in consanguineous partnerships, which is a high risk for birth defects . Finally, in this study, prematurity was responsible for nearly 7% of all stillbirths.…”

Section: Discussionsupporting

confidence: 50%

Global Network for Women's and Children's Health Research: probable causes of stillbirth in low‐ and middle‐income countries using a prospectively defined classification system

McClure

Garcés

Saleem

et al. 2017

BJOG

View full text Add to dashboard Cite

Objective We sought to classify causes of stillbirth for six lowmiddle-income countries using a prospectively defined algorithm.Design Prospective, observational study.Setting Communities in India, Pakistan, Guatemala, Democratic Republic of Congo, Zambia and Kenya.Population Pregnant women residing in defined study regions.Methods Basic data regarding conditions present during pregnancy and delivery were collected. Using these data, a computer-based hierarchal algorithm assigned cause of stillbirth. Causes included birth trauma, congenital anomaly, infection, asphyxia, and preterm birth, based on existing cause of death classifications and included contributing maternal conditions.Main outcome measures Primary cause of stillbirth.Results Of 109 911 women who were enrolled and delivered (99% of those screened in pregnancy), 2847 had a stillbirth (a rate of 27.2 per 1000 births). Asphyxia was the cause of 46.6% of the stillbirths, followed by infection (20.8%), congenital anomalies (8.4%) and prematurity (6.6%). Among those caused by asphyxia, 38% had prolonged or obstructed labour, 19% antepartum haemorrhage and 18% pre-eclampsia/eclampsia. About two-thirds (67.4%) of the stillbirths did not have signs of maceration.Conclusions Our algorithm determined cause of stillbirth from basic data obtained from lay-health providers. The major cause of stillbirth was fetal asphyxia associated with prolonged or obstructed labour, pre-eclampsia and antepartum haemorrhage. In the African sites, infection also was an important contributor to stillbirth. Using this algorithm, we documented cause of stillbirth and its trends to inform public health programs, using consistency, transparency, and comparability across time or regions with minimal burden on the healthcare system. Keywords Cause of death classification system, low-income countries, stillbirth.Tweetable abstract Major causes of stillbirth are asphyxia, preeclampsia and haemorrhage. Infections are important in Africa.

show abstract

“…A meta-analysis of 46 studies on consanguinity and links to early deaths showed a statistically significant 1.3 % higher number of infant deaths in children of first cousins than those born to non-consanguineous couples (Bittles 2012). Stillbirths were also higher by 0.5 % in first cousin progeny (Bittles 2012), and recent data continue to show increased stillbirths (Bellad et al 2012;Sørbye et al 2014) as well as increased infant deaths (Charafeddine et al 2012;Sørbye et al 2014) in children of consanguineous parents compared to non-consanguineous couples.…”

Section: The Research Sitementioning

confidence: 99%

UK Pakistani views on the adverse health risks associated with consanguineous marriages

2015

View full text Add to dashboard Cite

This is a qualitative study exploring the perceptions of members from the Pakistani/Kashmiri community living in Luton, UK, on the adverse health risks associated with consanguineous marriages. Rates of stillbirths and infant mortality are higher than the national average in Luton and the existing evidence base suggests that these higher rates may be associated with consanguinity (especially first cousin marriages) in highly consanguineous populations, such as the Pakistani/Kashmiri ethnic group. This qualitative study included 9 focus groups and 10 one to one in-depth interviews (n=58) with members from the Pakistani/Kashmiri community in Luton during 2012. Audio-recorded transcripts were analysed using framework analysis. Emerging themes included a limited knowledge, opposition to evidence and need for a more culturally sensitive health services approach. Findings from the focus group and interview discussions indicated that participants had a limited and varied understanding of genetic risk and indicated a lack of discussion within the community regarding genetic risk. They also opposed evidence that may link consanguineous marriages with infant mortality, stillbirth or genetic disorders that led to disability. The participants stressed the need for culturally sensitive and locally constructed services for information on genetic risk and services. These findings may be used to address higher rates of infant mortality and adverse health impacts associated with higher rates of consanguinity in Luton and elsewhere, through a partnership approach, improve upon current services and develop culturally appropriate services.

show abstract

Consanguinity, prematurity, birth weight and pregnancy loss: a prospective cohort study at four primary health center areas of Karnataka, India

Cited by 27 publications

References 26 publications

The Effect of Consanguinity on Neonatal Outcomes and Health

The Effect of Consanguinity on Neonatal Outcomes and Health

Global Network for Women's and Children's Health Research: probable causes of stillbirth in low‐ and middle‐income countries using a prospectively defined classification system

UK Pakistani views on the adverse health risks associated with consanguineous marriages

Contact Info

Product

Resources

About