Conscientiousness is associated with less amyloid deposition in cognitively normal aging.

Yoon, Bora; Baker, Suzanne L.; Korman, Deniz; Tennant, Victoria R; Harrison, Theresa M.; Landau, Susan

doi:10.1037/pag0000582

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…It has been well established that the pathological sequalae of dementia such as changes in brain structure and accumulation of amyloid plaques are known to begin up to two decades before the onset of cognitive disturbances (Bateman et al, 2012). Additionally, recent studies have found associations between FFM personality traits and Alzheimer's neuropathology (Aschenbrenner et al, 2020;Yoon et al, 2020). Therefore, we cannot make strong conclusions regarding the directionality of the relationship between personality and cognitive status based on the results of this study.…”

Section: Strengths and Limitationsmentioning

confidence: 63%

Premorbid personality traits as predictors for incident predementia syndromes: a multistate model approach

Schaeffer,

MacDonald,

Paterson

2024

J Int Neuropsychol Soc

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Objective: Associations have been found between five-factor model (FFM) personality traits and risk of developing specific predementia syndromes such as subjective cognitive decline (SCD) and mild cognitive impairment (MCI). The aims of this study were to: 1) Compare baseline FFM traits between participants who transitioned from healthy cognition or SCD to amnestic MCI (aMCI) versus non-amnestic MCI (naMCI); and 2) Determine the relationship between FFM traits and risk of transition between predementia cognitive states. Methods: Participants were 562 older adults from the Einstein Aging Study, 378 of which had at least one follow-up assessment. Baseline data collected included levels of FFM personality traits, anxiety and depressive symptoms, medical history, performance on a cognitive battery, and demographics. Follow-up cognitive diagnoses were also recorded. Results: Mann–Whitney U tests revealed no differences in baseline levels of FFM personality traits between participants who developed aMCI compared to those who developed naMCI. A four-state multistate Markov model revealed that higher levels of conscientiousness were protective against developing SCD while higher levels of neuroticism resulted in an increased risk of developing SCD. Further, higher levels of extraversion were protective against developing naMCI. Conclusions: FFM personality traits may be useful in improving predictions of who is at greatest risk for developing specific predementia syndromes. Information on these personality traits could enrich clinical trials by permitting trials to target individuals who are at greatest risk for developing specific forms of cognitive impairment. These results should be replicated in future studies with larger sample sizes and younger participants.

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Section: Strengths and Limitationsmentioning

confidence: 63%

Premorbid personality traits as predictors for incident predementia syndromes: a multistate model approach

Schaeffer,

MacDonald,

Paterson

2024

J Int Neuropsychol Soc

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“…In addition, individuals with a high level of conscientiousness have consistently been lower BMI and gained less weight over time, particularly during major life transitions [23]. It also suggests that this trait is linked to healthier biomarker profiles and improved physical functioning [24,25]. The most essential health-related activities, particularly physical exercise habits and healthy eating behavior, are reliably predicted by conscientiousness.…”

Section: Discussionmentioning

confidence: 99%

Associations of Personality Trait with Body Mass Index in Midlife

Saptarini¹,

Idaiani²,

Andarwati³

2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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Midlife people tend to gain weight with age, contributing to poor health. Personality traits are often linked to health outcomes that have adverse effects. The ways of thinking, feeling, and acting summed up by broad personality traits may make people more likely to become obese. The results of previous studies on the relationship between body weight and personality traits got different results. We determined the association between personality traits and BMI in males and females using large cross-sectional data from IFLS5. Body mass index was calculated by weight and height (kg/m 2 ). BMI was categorized into two groups; normal (BMI 18.5-24.9 kg/m 2 ) and overweight/obese (BMI ≥ 25 kg/m 2 ). We excluded underweight participants. We use the Big Five Inventory 15 (BFI 15), a set of 15 adjectives representing all 5 of the big five personality groups, including extraversion, agreeableness, openness, conscientiousness, and neuroticism. We adjusted the model with socioeconomic factors, health status, and behavioral factors. We used binary logistic regression to determine the association between personality traits and obesity. Data from 4,655 males and 5,154 females who participated in this study were included in the analysis. After being adjusted with potential confounders, Extraversion was significantly associated with obesity in males (AOR: 1.22; 95% CI 1.05-1.41) and females (AOR: 1.24; 95% CI 1.10-1.40). Conscientiousness was a protective factor for being overweight/obese in males (AOR: 0.83; 95% CI 0.72-0.95), and agreeableness was a protective factor for being overweight/obese in females (AOR: 0.88; 95% CI 0.78-0.99). The current results show how important it is to include phycological intervention in overweight/obesity therapy.

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“…For example, purpose in life 9 and the personality characteristic conscientiousness 10 have been associated with markedly reduced AD incidence. Novel neuroimaging and clinicopathologic findings have demonstrated that purpose in life 11 and conscientiousness, 12 among other psychological characteristics (e.g., resilience to stress, 13 optimism, 14 and trait mindfulness 15 ), may bestow protective benefit. Specifically, higher levels of conscientiousness and trait mindfulness and greater resilience to stress have been associated with less amyloid deposition and/or tau aggregation.…”

Section: Trial Registration Informationmentioning

confidence: 99%

Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults

et al. 2022

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Background and Objectives:Self-reflection (the active evaluation of ones thoughts, feelings and behaviours) can confer protection against adverse health outcomes. Its impact on markers sensitive to Alzheimer’s disease (AD), however, is unknown. The primary objective of this cross-sectional study was to examine the association between self-reflection and AD-sensitive markers.Methods:This study utilised baseline data from cognitively unimpaired older adults enrolled in the Age-Well clinical trial and older adults with subjective cognitive decline from the SCD-Well clinical trial. In both cohorts, self-reflection was measured via the reflective pondering subscale of the Rumination Response Scale, global cognition assessed via the Preclinical Alzheimer’s Cognitive Composite 5, and a modified late-life Lifestyle-for-Brain-Health (LIBRA) index computed to assess health and lifestyle factors. In Age-Well, glucose metabolism and amyloid deposition were quantified in AD-sensitive grey matter regions via FDG- and AV45-PET scans, respectively. Associations between self-reflection and AD-sensitive markers (global cognition, glucose metabolism, and amyloid deposition) were assessed via unadjusted and adjusted regressions. Further, we explored whether associations were independent of health and lifestyle factors. To control for multiple comparisons in Age-Well, false discovery rate corrected p-values (pFDR) are reported.Results:A total of 134 (mean age 69.3 ± 3.8 years, 61.9% female) Age-Well and 125 (mean age 72.6 ± 6.9 years, 65.6% female) SCD-Well participants were included. Across unadjusted and adjusted analyses self-reflection was positively associated with global cognition in both cohorts (Age-Well: adjusted-β = 0.22, 95% confidence interval [CI] 0.05-0.40, pFDR = 0.041; SCD-Well: adjusted-β = 0.18, 95% CI 0.03-0.33, p = 0.023) and with glucose metabolism in Age-Well after adjustment for all covariates (adjusted-β = 0.29, 95% CI 0.03-0.55, pFDR = 0.041). Associations remained following additional adjustment for LIBRA but did not survive FDR correction. Self-reflection was not associated with amyloid deposition (adjusted-β = 0.13, 95% CI -0.07-0.34, pFDR = 0.189).Discussion:Self-reflection was associated with better global cognition in two independent cohorts and with higher glucose metabolism after adjustment for covariates. There was weak evidence that relationships were independent from health and lifestyle behaviours. Longitudinal and experimental studies are warranted to elucidate whether self-reflection helps preserve cognition and glucose metabolism, or whether reduced capacity to self-reflect is a harbinger of cognitive decline and glucose hypometabolism.Trial Registration:Age-Well: NCT02977819; SCD-Well: NCT03005652

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Conscientiousness is associated with less amyloid deposition in cognitively normal aging.

Cited by 8 publications

References 48 publications

Premorbid personality traits as predictors for incident predementia syndromes: a multistate model approach

Premorbid personality traits as predictors for incident predementia syndromes: a multistate model approach

Associations of Personality Trait with Body Mass Index in Midlife

Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults

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