Conscious Attention Defect and Inhibitory Control Deficit in Parkinson’s Disease-Mild Cognitive Impairment: A Comparison Study With Amnestic Mild Cognitive Impairment Multiple Domain

Cammisuli, Davide Maria; Sportiello, Marco Timpano

doi:10.24869/psyd.2017.437

Cited by 2 publications

(3 citation statements)

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“…Comparing the three clusters on cognitive measures, we observed that the severity of memory deficits worsened with a progressive impairment of attention/ executive cognitive functioning in PD-MCI. Deficits in attention/executive functions (assessed by TMT parts A and B) increased from patients with PD-MCI and unimpaired memory (Cluster A), to patients included in Cluster B, and to patients of Cluster C. This scenario is consistent with the main view that cognitive disorders in PD without dementia are primarily mediated by attention/executive dysfunctions, 10,12,78,79 because of dopamine deafferentation of prefrontal-striatal circuitries. 4,5,80 Therefore, it can be argued that the deficits in dopamine-related attention/executive functions contribute to the episodic memory disorder of patients included in both Clusters B and C. Probably, in the former these deficits are the main factor affecting memory recall, whereas in the latter cluster the more severe recall impairment could be co-determined by prefrontal attention/executive deficits and by hippocampaldependent storage dysfunctions, usually depending on alterations in basal forebrain cholinergic system.…”

Section: Discussionsupporting

confidence: 85%

Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment

et al. 2023

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BackgroundMemory deficits in mild cognitive impairment related to Parkinson's disease (PD‐MCI) are quite heterogeneous, and there is no general agreement on their genesis.ObjectivesTo define memory phenotypes in de novo PD‐MCI and their associations with motor and non‐motor features and patients’ quality of life.MethodsFrom a sample of 183 early de novo patients with PD, cluster analysis was applied to neuropsychological measures of memory function of 82 patients with PD‐MCI (44.8%). The remaining patients free of cognitive impairment were considered as a comparison group (n = 101). Cognitive measures and structural magnetic resonance imaging‐based neural correlates of memory function were used to substantiate the results.ResultsA three‐cluster model produced the best solution. Cluster A (65.85%) included memory unimpaired patients; Cluster B (23.17%) included patients with mild episodic memory disorder related to a “prefrontal executive‐dependent phenotype”; Cluster C (10.97%) included patients with severe episodic memory disorder related to a “hybrid phenotype,” where hippocampal‐dependent deficits co‐occurred with prefrontal executive‐dependent memory dysfunctions. Cognitive and brain structural imaging correlates substantiated the findings. The three phenotypes did not differ in terms of motor and non‐motor features, but the attention/executive deficits progressively increased from Cluster A, through Cluster B, to Cluster C. This last cluster had worse quality of life compared to others.ConclusionsOur results demonstrated the memory heterogeneity of de novo PD‐MCI, suggesting existence of three distinct memory‐related phenotypes. Identification of such phenotypes can be fruitful in understanding the pathophysiological mechanisms underlying PD‐MCI and its subtypes and in guiding appropriate treatments. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Section: Discussionsupporting

confidence: 85%

Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment

et al. 2023

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“…The Brixton Spatial Anticipation Test (Burgess & Shallice, 1996) is regarded to be a measure of frontal executive function and is widely used in Europe in clinical practice (Lezak, Howieson, Bigler, & Tranel, 2012) and research (Bagshaw, Gray, & Snowden, 2014;Bayliss & Roodenrys, 2000;Cammisuli & Sportiello, 2017;Darcy et al, 2012;Hornberger et al, 2010;Lough et al, 2006;Lounes, Khan, & Tchanturia, 2011;Mang, Ridout, & Dritschel, 2018;McGuinness, Barrett, McIlvenna, Passmore, & Shorter, 2015;Primativo et al, 2017;Reay, Hamilton, Kennedy, & Scholey, 2006;Staios et al, 2013). The test requires participants to predict the location of a coloured dot as it moves over successive pages according to nine underlying rule occurrences.…”

Section: Introductionmentioning

confidence: 99%

“…The Brixton has been shown to be sensitive to brain dysfunction associated with a range of aetiologies, including Alzheimer's disease (Hornberger et al, 2010), amnestic multi-domain mild cognitive impairment (Cammisuli & Sportiello, 2017), amyotrophic lateral sclerosis (Staios et al, 2013), behavioural variant frontotemporal dementia (Hornberger et al, 2010;Lough et al, 2006;Primativo et al, 2017), Korsakoff's syndrome (van den Berg et al, 2009) and stroke (van den Berg et al, 2009;Vordenberg, Barrett, Doninger, Contardo, & Ozoude, 2014).…”

Section: Introductionmentioning

confidence: 99%

Is the Brixton Spatial Anticipation Test sensitive to frontal dysfunction? Evidence from patients with frontal and posterior lesions

Mole

Foddai

Chan

et al. 2020

Journal of Clinical and Experimental Neuropsychology

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Introduction: The Brixton Spatial Anticipation Test is a widely used neuropsychological test, regarded to be a measure of executive function. It is thought to be sensitive and impaired specifically in patients with frontal lobe lesions. We tested this assumption in patients with focal frontal or posterior lesions.Method: In this retrospective study, we compared performance on the Brixton in a sample of patients with focal frontal (n = 24) or posterior (n = 18) lesions and healthy controls (n = 22).Both overall performance on the test (total number of errors) and specific errors types were analysed.Results: We found no significant differences between frontal and posterior patients and healthy controls in overall Brixton performance. Moreover, patients with focal frontal lesions did not generate a significantly greater number of any type of error than posterior patients or healthy controls. Performance was also intact in patients with lesions involving left lateral (n = 11), right lateral (n = 10) or superior medial (n = 18) frontal subregions. Although the error analysis showed that posterior patients had a greater tendency to guess and make more errors when following specific rules than healthy controls, this was no longer significant once fluid intelligence was controlled for.Conclusions: While it is likely that the Brixton draws on a range of cognitive abilities, caution should be taken when drawing conclusions about its neural substrates.

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Conscious Attention Defect and Inhibitory Control Deficit in Parkinson’s Disease-Mild Cognitive Impairment: A Comparison Study With Amnestic Mild Cognitive Impairment Multiple Domain

Cited by 2 publications

References 38 publications

Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment

Memory Phenotypes In Early, De Novo Parkinson's Disease Patients with Mild Cognitive Impairment

Is the Brixton Spatial Anticipation Test sensitive to frontal dysfunction? Evidence from patients with frontal and posterior lesions

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