Consciousness, awareness of insight and neural mechanisms of schizophrenia

Touskova, Tereza; Bob, Petr

doi:10.1515/revneuro-2014-0063

Cited by 11 publications

(7 citation statements)

References 139 publications

(217 reference statements)

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“…It is a failure to make consensually valid sense of complex and potentially traumatic experiences. This view is consistent with studies of firstperson experience of psychosis, which demonstrate that insight is most significant to persons with psychosis when it helps them make sense or meaning of life events in a narratized manner [191][192][193][194] .…”

Section: Summary and Future Directionssupporting

confidence: 84%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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Section: Summary and Future Directionssupporting

confidence: 84%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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“…What becomes split in dissociation phenomena: the personality, the identity or some psychic functions like cognition and affectivity? (4)(5)(6). In the light of current evidence for overlapping symptoms between schizophrenia and complex PTSD, especially when traumatic events like sexual abuse, child maltreatment or neglect occur in the childhood, this question links to the nature of "splitting of the mind" that is at the basis of the concept of "schizophrenia", as was proposed by Egon Bleuler in 1911 (7,8).…”

Section: Zusammenfassungmentioning

confidence: 99%

Do concepts of childhood trauma and dissociation provide an epistemological linkage between schizophrenia and PTSD?

Peña-Salazar¹,

Nebot²,

Álvarez³

et al. 2016

Nervenheilkunde

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Zusammenfassung Hintergrund: Seit Bleuler und Janet wurde der Betrachtung von Schizophrenie als dissoziatives Phänomen wenig Beachtung geschenkt. Eine strikte Trennung zwischen Schizophrenie als ausschließlich biologischen Prozess und dissoziativen Störungen als alleinige Folge von traumatischen Erlebnissen in der Kindheit ist inzwischen überwunden. Methode: Die Autoren wählen eine narrative Literaturübersicht, die mögliche Zusammenhänge zwischen Kindheitstraumata, dissoziativen Störungen und psychotischen Symptomen in der Allgemeinbevölkerung als auch bei an Schizophrenie leidenden Menschen empirisch untersuchen. Wissenschaftstheoretische Partikularitäten postulierter Zusammenhangsannahmen werden diskutiert. Ergebnisse: Die untersuchte Literatur legt die Annahme nahe, dass schizophrene Menschen, die gleichzeitig dissoziative Störungen aufweisen, unter stärkeren positiven psychotischen Symptomen, häufiger Komorbidität und höherer Krankheitsbelastung leiden. Andererseits weisen Patienten mit „strukturellen dissoziativen Störungen“ phänomenologische Ähnlichkeiten mit schizophrenen Patienten. Gemeinsame biologische als auch psychologische Erklärungsansätze werden diskutiert. Schlussfolgerungen: Anhand der hier diskutierten empirischen Ergebnissen darf beim heutigen Wissensstand davon ausgegangen werden, dass sowohl posttraumatische Belastungsstörungen (PTSD) als auch schizophrene Psychosen auf biologischen als auch auf eine das Selbst vor unerträglichen Bedrohungen schützende Abwehrfunktionen basieren, jedoch klinisch und phänomenologisch unterschiedlich zum Ausdruck kommen.

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“…In social situations these difficulties can lead to confusion, paranoid interpretations and inappropriate reactions that can make it difficult for these individuals to forge and sustain friendships or social relationships (Mazurek 2010; Harley 2012). They can also show deficits in awareness of self and others and in the ability to make an accurate evaluation of reality, of the emotional content of social scenes/situations and of their inner states (Sasson 2007; Williams 2010; Touskova 2015). Nevertheless, studies have also found different patterns of social cognition abnormalities between the groups and it has even been suggested that these disorders exhibit diametric deficits, with theory of mind being underdeveloped in autism spectrum conditions and overdeveloped in psychosis (Crespi 2008; Bara 2011).…”

Section: Boundaries and Overlapsmentioning

confidence: 99%

Autism spectrum disorder and schizophrenia: boundaries and uncertainties

Pina‐Camacho¹,

Parellada²,

Kyriakopoulos³

2016

BJPsych advances

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SummaryAutism and schizophrenia were placed in different diagnostic categories in DSM-III, having previously been considered as related diagnostic entities. New evidence suggests that these disorders show clinical and cognitive deficit overlaps and shared neurobiological characteristics. Furthermore, children presenting with both autism spectrum disorder (ASD) and psychotic experiences may represent a subgroup of ASD more closely linked to psychosis. The study of ASD and childhood schizophrenia, and their clinical boundaries and overlapping pathophysiological characteristics, may clarify their relationship and lead to more effective interventions. This article discusses the relationship through a critical review of current and historical dilemmas surrounding the phenomenology and pathophysiology of these disorders. It provides a framework for working with children and young people with mixed clinical presentations, illustrated by three brief fictional case vignettes.

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Consciousness, awareness of insight and neural mechanisms of schizophrenia

Cited by 11 publications

References 139 publications

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Do concepts of childhood trauma and dissociation provide an epistemological linkage between schizophrenia and PTSD?

Autism spectrum disorder and schizophrenia: boundaries and uncertainties

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