Consecutive antibiotic treatment with doxycycline and marbofloxacin clears bacteremia in Mycoplasma haemofelis -infected cats

Novacco, Marilisa; Sugiarto, Sarah; Willi, Barbara; Baumann, Julia; Spiri, Andrea M.; Oestmann, A; Riond, Barbara; Boretti, Felicitas S; Naegeli, Hanspeter; Hofmann‐Lehmann, Regina

doi:10.1016/j.vetmic.2018.03.006

Cited by 19 publications

(25 citation statements)

References 30 publications

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“…Human infections with swine and ovine hemoplasmas have also been reported 42,43 . Finally, as was the case in the experimentally hemoplasma-infected cats included in a recent study 44 , clearance of infection may be a requirement of re-homing.…”

Section: Treatment When To Treatmentioning

confidence: 91%

“…In M. haemofelis-infected cats, clinical signs have resolved without their administration 19,21 , suggesting that they are not necessary. Moreover, immunosuppression induced by corticosteroid administration has been used in experimental studies with the aim of enhancing infection or inducing recrudescence of bacteremia 15,44,52 . Further studies are required to determine whether corticosteroids at any dose rate are detrimental or beneficial; however, it is generally accepted that they may be indicated pending confirmation of diagnosis.…”

Section: Supportive Managementmentioning

confidence: 99%

“…Specific management -chronic carrier status A recent study described a treatment protocol that consistently cleared M. haemofelis infection in a small number (n=15) of chronically infected cats 44 . Furthermore, following immunosuppression recrudescence was not detected.…”

Section: Specific Management -Hemoplasmosismentioning

confidence: 99%

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Update on Feline Hemoplasmosis

Barker

2019

Veterinary Clinics of North America: Small Animal Practice

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Disclosure statement Employed by Langford Vets, a wholly owned subsidiary of University of Bristol, whom offer a quantitative PCR assay for the detection of canine and feline haemoplasmas. Author's PhD on the molecular characterization of companion animal hemoplasmas was part funded by Zoetis (previously Pfizer Animal Health).Abstract/Summary [this will be used for indexing services and does not appear with article]

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Section: Treatment When To Treatmentioning

confidence: 91%

Section: Supportive Managementmentioning

confidence: 99%

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Update on Feline Hemoplasmosis

Barker

2019

Veterinary Clinics of North America: Small Animal Practice

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“…This was initiated immediately after the cat was confirmed to have hemotropic mycoplasmosis. However, cats that are non-responsive to doxycycline are usually placed on marbofloxacin at 2 mg/kg b.wt twice daily for 14 days [13]. Due to the immune-mediated nature of mycoplasmosis pathogenesis, prednisone administration was withheld despite its strategic importance in reducing the humoral immune response vital for the pathogenesis of extravascular hemolysis [7].…”

Section: Discussionmentioning

confidence: 99%

Feline hemotropic mycoplasmosis concurrent with bacterial cystitis in a domestic shorthair cat

2018

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Objective: The main aim of this case report is to present a case of feline hemotropic mycoplasmosis that occurred concurrently with bacterial cystitis following the bite. Material and methods: A 3-year-old intact male domestic shorthair cat weighing 3.7 kg was referred to the Universiti Malaysia Kelantan Veterinary Clinic with clinical signs of hematuria and dysuria. History revealed that it was managed outdoor, fed with kibbles and wet food, but with no vaccination and deworming. Upon physical examination, the cat had a dull appearance, pale mucous membrane, normal respiratory rate, hypothermia, and bradycardia. Upon the examination of the urogenital system, there were urine burns at the anal region, necrotized penile tip, and presence of bite wound observed at the perineal region. Turgid and enlarged urinary bladder was identified upon palpation. Results: Diagnostic investigation revealed the hemotropic mycoplasmosis via microscopy, while urine culture was positive for Escherichia coli infection. The cat was successfully treated symptomatically. Conclusion: However, the prognosis of this cat was guarded given that the anemia was unresolved at the point of discharge.

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“…Symptoms of Mp infection generally resolve within 3-4 weeks after disease onset but can be shortened with antibiotic therapy; macrolides and doxycycline are the mainstay of this treatment (14). The mainstay for the prevention of pigment-induced acute kidney injury is the correction of volume depletion, prevention of intratubular cast formation, and the treatment of the underlying cause of rhabdomyolysis (4).…”

Section: Discussionmentioning

confidence: 99%