Consecutive Microscopic Anatomical Characteristics of the Lacrimal Sac and Nasolacrimal Duct: Cases With or Without Inflammation

Mito, Hidenori; Takahashi, Yasuhiro; Nakano, Takashi; Asamoto, Ken; Ikeda, Hiroshi; Kakizaki, Hirohiko

doi:10.1167/iovs.14-14449

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…But as noted here and in previous research, the disease can also occur in younger individuals. In the pathology sections, we observed established fibrosis and various degrees of lymphocyte and plasmocyte infiltration in the sac wall of the chronic dacryocystitis patients, similar to the findings of Mauriello et al (7)(8)(9).…”

Section: Discussionsupporting

confidence: 89%

Investigating estrogen and progesterone receptors in the lacrimal sacs of individuals with and without chronic dacriocystitis

Baybora¹

2019

Beyoglu Eye J

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IntroductionChronic dacryocystitis is a long-lasting, non-infectious inflammation of the lacrimal sac that leads to epiphora (1). It is more common in females than males (2), which may be due, at least in part, to the anatomically narrower nasolacrimal duct in females (3). The exact pathophysiology is not clear.Age seems an important factor, since most chronic dacryocystitis patients are middle-aged, although young individuals may also be affected. A lack of the estrogen hormone may be a cause and explain the presence of the disease in some males, (4) but this does not explain the presence of chronic dacryocystitis in premenopausal females. The presence or Objectives: Chronic dacryocystitis is usually seen in middle-aged or older women, suggesting that decreased estrogen and progesterone serum levels may be a causative factor in the disease pathology. However, the occurrence of the disease in premenopausal females and males suggests that there may be more to the explanation than the level of female sex hormones. The purpose of the present study was to investigate estrogen and progesterone receptor positivity in the lacrimal sacs of individuals with and without chronic dacryocystitis. Methods: The study group included 50 female and 20 male patients diagnosed with chronic dacryocystitis. Lacrimal sac samples were taken during a dacryocystorhinostomy. The control group comprised 29 cadavers with no evidence of lacrimal system pathology in the health records. The samples were obtained transconjunctivally. Lacrimal sac samples from both groups were stained with the estrogen and progesterone receptor protein antigen. Fisher's exact test and a chi-square test were used to compare the receptor positivity results of premenopausal and postmenopausal women, and samples of those with dacryocystitis and cadaver sacs without the disease. Results: In the control group, estrogen receptor positivity was observed in the samples of 2 premenopausal females. In the study group, estrogen receptor positivity was seen in 4 premenopausal females. There was no significant difference in estrogen receptor positivity between the premenopausal and postmenopausal female groups (p=0.41). A similar result was not established between the premenopausal and postmenopausal females in case group (p=0.056). No comparison was made of the progesterone receptor because only 1 example of progesterone receptor positivity was found in a premenopausal female in the dacryocystitis group. Conclusion: Estrogen receptor positivity did not seem to be a factor in chronic dacryocystitis physiopathology.

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Section: Discussionsupporting

confidence: 89%

Investigating estrogen and progesterone receptors in the lacrimal sacs of individuals with and without chronic dacriocystitis

Baybora¹

2019

Beyoglu Eye J

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“…Because the inner diameter of the nasolacrimal duct is narrower than that of the lacrimal sac, 8,9 the NLD may be easily obstructed when it is injured during maxillary sinus surgery. However, permanent NLDO may be prevented by securing the lumen via silicone intubation into the NLD before scar formation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, many goblet cells are distributed throughout the inferior nasolacrimal duct. 8 Because goblet cells secrete mucin, this antiadhesion effect is also helpful for prophylaxis against obstruction. 10 Understanding the course of the NLD during maxillary sinus surgery is difficult.…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive imaging studies of nasolacrimal duct obstruction secondary to maxillary sinus surgery

Takahashi

Miyazaki

Ichinose

et al. 2016

Canadian Journal of Ophthalmology

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“…Ilyenkor merül fel a jelentősége a könnytömlő falát borító csillőszőrös hengerhám épségének [14][15][16][17]. Ugyanerre hívja fel a figyelmet Mito és munkacsoportja: ők kadáverkönnytömlők szövettani vizsgálatai során azt állapították meg, hogy súlyosan károsodott volt a csillószőrös hengerhám azon saccusok falának belső felszínén, amelyeknél gyulladásos jeleket is találtak [18].…”

Section: Eredeti Közleményunclassified

Dacryocystorrhinostomia műtétek során eltávolított könnytömlőminták szövettani elemzése

et al. 2018

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Introduction: Endonasal dacryocystorhinostomy (EDCR) has good results. Aim: To perform a prospective histological investigation of the removed lacrimal sacs’ walls. Method: Between 2016 and 2017, we carried out 21 operations in two groups: inflammatory (11 patients) and non-inflammatory (10 patients) lacrimation groups. The mean age was 60.5 years. Histological samples were investigated after staining them with hematoxylin-eosin. Results: In the non-inflammatory group, histology revealed the incipient metaplasia of the ciliated goblet cells. In the lacrimal sac’s wall, there is a chronic inflammation with mucinous metaplasia of the serous glands. In the inflammatory group, the metaplasia of the ciliated goblet cells is more pronounced. Chronic fibrotic inflammation destroys the lacrimal sac’s wall, which is dilated, ruptured. The mucinous metaplasia of the serous glands is pronounced. Conclusions: The results of histological investigations of the lacrimal sacs removed in the course of EDCR are much alike in the inflammatory and non- inflammatory groups. Orv Hetil. 2018; 159(52): 2207–2211.

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Consecutive Microscopic Anatomical Characteristics of the Lacrimal Sac and Nasolacrimal Duct: Cases With or Without Inflammation

Abstract: Consecutive microscopic anatomical characteristics of the lacrimal sac and nasolacrimal duct were different from each other. A narrowed part of the nasolacrimal duct lumen is speculated to be a risk for obstruction.

Cited by 15 publications

References 14 publications

Investigating estrogen and progesterone receptors in the lacrimal sacs of individuals with and without chronic dacriocystitis

Investigating estrogen and progesterone receptors in the lacrimal sacs of individuals with and without chronic dacriocystitis

Comprehensive imaging studies of nasolacrimal duct obstruction secondary to maxillary sinus surgery

Dacryocystorrhinostomia műtétek során eltávolított könnytömlőminták szövettani elemzése

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