Consenso colombiano para la prevención, diagnóstico y manejo de condiciones trombóticas en pacientes adultos con COVID-19: aplicando el Marco de la Evidencia a la Decisión (EtD) GRADE

Acevedo-Peña, Juan

doi:10.36104/amc.2021.2078

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…Uma justificativa plausível para esse número expressivo frente as demais complicações seriam os mecanismos utilizados pelo coronavírus para entrar nas células de seus hospedeiros; a predileção pelos receptores de angiotensina-2, abundantemente presentes em células do trato respiratório, favorece a instalação do vírus nessa região, onde põe em atividade seus mecanismos de lesão endotelial e hipercoagulabilidade 7,8,9 .…”

Section: Evento Vascular óBito or (Ic 95%) P-valor Or (Ic 95%) P-valorunclassified

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Análise Do Perfil Clínico-Epidemiológico De Pacientes Com Eventos Vasculares Decorrentes Da Covid-19 No Hospital Regional De Presidente Prudente

Toreto,

Camargo,

Martins

et al. 2023

COLLOQ VITAE

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The COVID-19 pandemic has highlighted weaknesses in health systems around the world. At the beginning of the pandemic, several authors observed non-respiratory complications in patients of different ages and races, which drew attention to the nature of the novel coronavirus infection, which was hardly restricted to the respiratory tract. Evidence has shown that the pathophysiology of the virus is closely related to coagulation disorders, which favors the emergence of thrombotic events. The aim of this article is to highlight the epidemiological experience of a tertiary public hospital during the first year of the pandemic and the vascular complications observed. The study found that complications were more frequent in older patients, but there was no significant difference between race or gender. We conclude that understanding the behavior of COVID-19, not just the respiratory behavior, is fundamental, as vascular complications are real and need to be understood through new and extensive studies.

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Section: Evento Vascular óBito or (Ic 95%) P-valor Or (Ic 95%) P-valorunclassified

“…Pesquisas recentes demonstram que essa afinidade pode aumentar a capacidade do vírus de causar comprometimentos sistêmicos, uma vez que a ECA 2 não se limita aos sistema respiratório. O vírus entra na célula que expressa ECA 2, usando-a como um receptor 7,8,9 .…”

Section: Introductionunclassified

Análise Do Perfil Clínico-Epidemiológico De Pacientes Com Eventos Vasculares Decorrentes Da Covid-19 No Hospital Regional De Presidente Prudente

Toreto,

Camargo,

Martins

et al. 2023

COLLOQ VITAE

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“…However, at the moment there is no consensus about using PESI in patients with PE secondary to COVID-19. 14,15 There are multiple concerns about PESI underestimating mortality risk in this context and this hypothesis has not been evaluated yet.…”

Section: Introductionmentioning

confidence: 99%

Validation of the PESI Scale to Predict in-Hospital Mortality in Patients with Pulmonary Thromboembolism Secondary to SARS CoV − 2 Infection

Muñoz

Ruiz-Talero

Hernández-Flórez

et al. 2022

Clin Appl Thromb Hemost

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Objective To evaluate the discriminative ability and the calibration of the Pulmonary Embolism Severity Index (PESI) to predict in-hospital mortality in patients with Pulmonary Embolism (PE) secondary to COVID 19 in two hospitals in Bogotá. Methods External validation study of a prediction model based on a retrospective cohort of patients with PE secondary to COVID-19 treated at Hospital Universitario San Ignacio and Hospital universitario La Samaritana, between March 2020 and August 2021. Calibration of the scale was evaluated using the Hosmer-Lemeshow test and a calibration belt diagram. Discrimination ability was evaluated using a ROC curve. Results 272 patients were included (median age 61.5 years, male 58.8%). PE was diagnosed in 45.6% of the patients at the time of admission. Of the remaining 54.4%, 95.9% received thromboprophylaxis until the time of diagnosis.17.6% of the patients died. Regarding calibration, the scale systematically underestimates risk in all classes of PESI. For class I, the ratio of observed/expected events was 4.4 vs 0.8%, class II 4.8 vs 1.8%, class III 15.2 vs 4.2%, class IV 14.3 vs 5.9% and class V 46.7 vs 5.8%. The calibration test rejected the adequate calibration hypothesis (p < 0.001). The discriminatory ability was adequate (AUC = 0.7128, 95% CI 0.63-0.79). Conclusions The PESI scale in patients with PE secondary to COVID 19 underestimates the risk of in-hospital mortality, while maintaining adequate discrimination. It is suggested not to use the PESI scale until it is recalibrated in this context.

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Consenso colombiano para la prevención, diagnóstico y manejo de condiciones trombóticas en pacientes adultos con COVID-19: aplicando el Marco de la Evidencia a la Decisión (EtD) GRADE

Cited by 2 publications

References 30 publications

Análise Do Perfil Clínico-Epidemiológico De Pacientes Com Eventos Vasculares Decorrentes Da Covid-19 No Hospital Regional De Presidente Prudente

Análise Do Perfil Clínico-Epidemiológico De Pacientes Com Eventos Vasculares Decorrentes Da Covid-19 No Hospital Regional De Presidente Prudente

Validation of the PESI Scale to Predict in-Hospital Mortality in Patients with Pulmonary Thromboembolism Secondary to SARS CoV − 2 Infection

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