Consensus Conference on Platelet Transfusion: Final Statement

Contreras, M.

doi:10.1046/j.1423-0410.1998.7520173.x

Cited by 9 publications

(9 citation statements)

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“…88 -90 In addition to thrombocytopenia, intrinsic platelet function is impaired by acidosis and hypothermia, which can develop in severely injured patients who require MT. 94,95 The importance of platelets in MT was studied in a single randomized trial that noted no difference in microvascular bleeding, though the platelet group received a low platelet:RBC ratio of 0.5:1. 94,95 The importance of platelets in MT was studied in a single randomized trial that noted no difference in microvascular bleeding, though the platelet group received a low platelet:RBC ratio of 0.5:1.…”

Section: Discussionmentioning

confidence: 99%

Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

et al. 2008

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“…Low platelet counts (<50 Â 10 9 /l) are considered as a major risk factor for bleeding complications [12]. TEG maximum amplitude is considered as the parameter best reflecting the effect of platelet count.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography

Roeloffzen¹,

Kluin-Nelemans²,

Mulder

et al. 2010

Blood Coagulation &Amp; Fibrinolysis

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ВведениеКровопотеря является актуальной проблемой анестезиологии реаниматологии [1][2][3][4]. Акушерские кровотечения являются частыми и грозными осложне ниями беременности и родов, а в структуре причин ма теринской смертности они занимают 25-30% [5, 6]. Только 65% родов через естественные пути сопровож даются физиологической кровопотерей, 1/3 пациенток теряет от 500 до 1000 мл крови, а в 3-8% случаев объ ем кровопотери превышает 1200-1500 мл и считается IntroductionBlood loss is the urgent problems in anestesiology and reanimatology [1][2][3][4]. Obstetric hemorrhage is frequent and serious complication of pregnancy and childbirth. It causes maternal mortality in 25-30% [5, 6]. Only 65% of births occuring through natural ways are accompanied by physio logical hemorrhage, in which one third of patients lose 500 to 1000 ml of blood/ In 3-8% of patients the amount of blood loss exceeds 1200-1500 ml that is considered as a massive obstetric hemorrhage (MOH) [7, 8]. In MOH the

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“…A 1992 survey by the AABB of 630 hospitals demonstrated considerable variation in platelet transfusion practice and judged this to be due in large part to the inadequate scientific evidence on which to base decision making [70]. Several different associations published guidelines addressing platelet transfusion, and a listing of these and other transfusion‐related guidelines can be found at http://www.aabb.org/docs/ofintpractice.htm. The most recent guidelines found have been published by the Royal College of Physicians of Edinburgh in 1998 [61,71,72] and by the American Society of Anesthesiologists (ASA) in 1996. The latter are available at http://www.asahq.org/practice/blood/blood__component.html[73].…”

Section: Clinical Approach To Thrombocytopenia In the Icumentioning

confidence: 99%

“…Based on a retrospective study of 11 patients with ITP or quinidine‐induced thrombocytopenia, it has been recommended by others to transfuse platelets to patients with ITP in the face of life‐threatening bleeding, ocular hemorrhage, or when patients undergoing major surgery have excessive nonsurgical bleeding. Two‐thirds of the patients studied had significant increases in their platelet counts, although sometimes requiring large doses of platelets [72,80,93].…”

Section: Idiopathic Thrombocytopenic Purpuramentioning

confidence: 99%

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Thrombocytopenia and Critical Care Medicine

Gelinas¹,

Stoddart²,

Snyder³

2001

J Intensive Care Med

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Platelet transfusions play an important role in the treatment of critically ill patients. Like any blood component, however, there are various aspects of platelet transfusion therapy that need be considered by the intensivist. These include the proper dose and type of platelet component to infuse, as well as the route and method of administration. Methods to reduce the volume of the transfused platelets, for example, must ensure that the infused platelets will be functional and viable, posttransfusion. Treatment and diagnosis of the HLA alloimmunized recipient can pose a serious challenge to the clinician and an obstacle to adequate platelet therapy. An ICU patient for whom an adequate posttransfusion platelet increment cannot be achieved is at great risk of suffering a fatal hemorrhage. The ICU physician should be aware of the techniques used in modern transfusion practice to avoid having to deal with this complication. Adverse reactions to platelet transfusion include not only serologic ones, but those related to febrile and allergic complications, as well as infectious complications. The latter group includes diseases caused by infection with cytomegalovirus, bacteria, and a cadre of viruses including HIV and hepatitis. The clinical approach to thrombocytopenia in the ICU will be covered in some detail in an effort to review many of the conditions associated with recipient thrombocytopenia, including ITP, TTP, dilutional thrombocytopenia, DIC, surgery, HELLP syndrome, and drug‐induced thrombocytopenia. Unfortunately the treatment approaches traditionally used are not always derived from evidence‐based studies. This review covers many of these topics in an attempt to help physicians become better able to manage thrombocytopenia in the ICU and thus provide the best transfusion therapy for their patients.

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Consensus Conference on Platelet Transfusion: Final Statement

Cited by 9 publications

References 0 publications

Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography

Thrombocytopenia and Critical Care Medicine

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