Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT

Abstract

A classification system and criteria for OCT-defined atrophy in the setting of AMD has been proposed based on an international consensus. This classification is a more complete representation of changes that occur in AMD than can be detected using color fundus photography alone. Longitudinal information is required to validate the implied risk of vision loss associated with these terms. This system will enable such future studies to be undertaken using consistent definitions.

Multimodal Imaging Patterns for Development of Central Atrophy Secondary to Age-Related Macular Degeneration

“…24 For this study, we adopted the recently proposed definition of cRORA that has been brought forward as part of the CAM program consensus classification system. 29 A better classification that becomes widely established would be also helpful for interpretation of other potential precursor lesions that have been recently described by SD-OCT, such as thinning of retinal layers in the presence of drusen regression, evolution of HRF, and disintegrated RPE dots. 23,[26][27][28][47][48][49][50][51] Various limitations of this study need to be considered.…”

“…23,[25][26][27][28] Among those observations, ''nascent GA'' as part of the chronological appearance of drusen-associated atrophy development has been analyzed by Wu et al 26 Recently, the Classification of Atrophy Meetings (CAM) group defined OCT-based criteria for complete RPE and outer retinal atrophy (cRORA) as atrophy in AMD. 29 The aim of the current study was to analyze the incidence and development of central atrophy in AMD eyes that were considered at high risk for development of late AMD stages. Hereby, the term ''central'' referred to the presence of atrophy within the central subfield of the Early Treatment in Diabetic Retinopathy Study (ETDRS) grid.…”

Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression

“…(complete RPE and outer retinal atrophy or cRORA) was defined using the Classification of Atrophy Meeting (CAM) criteria 18 as hypertransmission of OCT signal into the choroid (at least 250 lm in diameter) with an overlying RPE defect and thinning of the outer retina. A pigment epithelial detachment was considered suspicious for CNV based on its shape (irregular elevation), heterogeneous internal reflectivity, and/ or presence of exudation (intraretinal, subretinal, sub-RPE fluid).…”

Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

“…[1][2][3][4][5] These two limitations have started to be addressed with the widespread availability of MMI techniques and the development and manufacture of scotopic perimeters. The advances in MMI with fundus autofluorescence (FAF), near infrared (NIR), and spectral-domain optical coherence tomography (SD-OCT) imaging allowed features, such as SDD, [7][8][9][10] hyperreflective foci, [11][12][13] and nascent geographic atrophy (nGA), 14,15 all of which are considered to be associated with an increased risk of vision loss in AMD, to be identified. Instruments, such as the scotopic Nidek microperimeter (MP-1S; Nidek Technologies, Padova, Italy) 16 and the scotopic Macular Integrity Assessment (S-MAIA; CenterVue, Padova, Italy) microperimeter, 16,17 were designed to allow static rodmediated function to be assessed at multiple locations within the macula in the one testing session.…”