Consensus-Derived Practice Standards Plan for Complicated Kaposiform Hemangioendothelioma

Drolet, Beth A.; Trenor, Cameron C.; Brandão, Leonardo R.; Chiu, Yvonne E.; Chun, Robert H.; Dasgupta, Roshni; Garzon, María C.; Hammill, Adrienne M.; Johnson, Craig M.; Tlougan, Brook E.; Blei, Francine; David, Michèle; Elluru, Ravindhra G.; Frieden, Ilona J.; Friedlander, Sheila Fallon; Iacobas, Ionela; Jensen, John; King, David M.; Lee, Margaret T.; Nelson, Stephen C.; Patel, Manish; Pope, Elena; Powell, Julie; Seefeldt, Marcia; Siegel, Dawn H.; Kelly, Michael; Adams, Denise M.

doi:10.1016/j.jpeds.2013.03.080

Cited by 241 publications

(290 citation statements)

References 50 publications

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“…Wide local excision when possible and feasible is recommended [95]. Resolution of KMS has been reported in cases when complete resection is achieved [40,66,[96][97][98][99].…”

Section: Surgical Managementmentioning

confidence: 99%

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

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Kasabach-Merritt syndrome (KMS) consists of a clinical trial of capillary hemangioma, thrombocytopenia and disseminated intravascular coagulation. KMS occurs most commonly in the pediatric population, and its occurrence in adults is rare. Specific guidelines or randomized clinical trials guiding clinical management of KMS in adult patients are lacking. This manuscript provides a comprehensive review of KMS and discusses recent advances in the medical management of KMS. We also propose a systematic therapeutic approach which would serve as a guide in the management of adult patients with KMS caused by hemangiomas.

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“…Wide local excision when possible and feasible is recommended [95]. Resolution of KMS has been reported in cases when complete resection is achieved [40,66,[96][97][98][99].…”

Section: Surgical Managementmentioning

confidence: 99%

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

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“…In particular, vincristine has been reported to cause loss of deep tendon reflexes, peripheral neuropathy and abdominal autonomic disturbance, such as constipation (21). The effects of angiography and embolization have been shown to be temporary and are used primarily as an adjunct to surgery, in order to minimize bleeding during a planned resection (22). In certain refractory cases, in which the patient cannot be tapered off of the corticosteroids, chemotherapy is used.…”

Section: Kms Was First Noted By Kasabach and Merritt In 1940 (1) Enjmentioning

confidence: 99%

Multimodal treatment of Kasabach-Merritt syndrome arising from tufted angioma: A case report

Jiang

Zhao

2017

Oncology Letters

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Abstract. Kasabach-Merritt syndrome (KMS) is a rare type of vascular tumor associated with a severely decreased platelet count. No standard guidelines for the treatment of the disease have been established so far. In the present study, a 1-year-old pediatric patient with KMS arising from tufted angioma was successfully and variously treated with steroids, vincristine, surgery and propranolol for 18 months. Systemic steroids stabilized the platelet count stable, while vincristine reduced the size of the tumor. Due to unpredictable response, the patient was operated. Combination of vincristine and propranolol was introduced post-surgery to improve the severely low platelet count of the patient. Following multimodal therapy for 18 months, there has been no evidence of recurrence or metastasis during 2 years of follow-up. Currently, the patient is alive and well. The management of KMS presents a challenge, and well-designed studies are required to clearly determine the benefits and risks of multidisciplinary treatment.

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“…From the literature, we identified 14 KHE patients with bone involvement, but only 1 adult has been reported with humeral involvement [3]. Resection combined with radiation or medical treatments has been considered for KHE patients with varying degrees of success [18]. In the current study, we report a rare case of KHE that occurred primarily in the bone of an adult patient without cutaneous changes or KMS.…”

Section: Introductionmentioning

confidence: 89%

CyberKnife Treatment for Kaposiform Hemangioendothelioma of the Ilium in an Adult: Case Report and Review of the Literature

Wang¹,

Kong

Wu³

et al. 2014

Oncol Res Treat

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Background: Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that mainly affects infants. KHE rarely develops in adolescents and adults. These tumors tend to be locally invasive, but are not known to produce distant metastases. Numerous treatment modalities are available for KHE, but the optimal therapy is unknown. Case Report: A 51-year-old woman was diagnosed with KHE of the ilium in September 2005. The lesion recurred within 5 years of local excision, and was subsequently treated with CyberKnife. Within 1 month of CyberKnife therapy, pain intensity was significantly reduced and the patient's quality of life was significantly improved. Since January 2011, she has remained pain-free and has had no signs of recurrence or metastasis for more than 2 years following CyberKnife therapy. Conclusion: We report the first CyberKnife treatment of an adult with KHE of the bone without accompanying cutaneous changes and Kasabach-Merritt syndrome. CyberKnife treatment could be a useful temporizing measure for bone KHE.

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Consensus-Derived Practice Standards Plan for Complicated Kaposiform Hemangioendothelioma

Cited by 241 publications

References 50 publications

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Multimodal treatment of Kasabach-Merritt syndrome arising from tufted angioma: A case report

CyberKnife Treatment for Kaposiform Hemangioendothelioma of the Ilium in an Adult: Case Report and Review of the Literature

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