Consensus document on dog and cat allergy

Dávila, Ignacio; Domínguez‐Ortega, Javier; Navarro‐Pulido, A.; Alonso, Ana María Fernández; Antolín‐Amérigo, Darío; González-Mancebo, E; Martín‐García, Cristina; Núñez-Acevedo, Beatriz; Prior, Nieves; Reche, Marta; Rosado, Ana; Ruíz-Hornillos, Javier; Sánchez, M. García; Torrecillas, M.

doi:10.1111/all.13391

Cited by 97 publications

(189 citation statements)

References 102 publications

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“…To date, eight cat‐origin allergens have been identified and registered through the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub‐Committee . Fel d 1, a secretoglobin, is the major cat allergen . (Table ) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1 .…”

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…All cats produce Fel d 1 regardless of breed, age, hair length, sex, housing (indoors vs outdoors), or body weight; there are no allergen‐free or hypoallergenic cats . Fel d 1 production varies widely among individual cats and may vary widely throughout the year in the same cat .…”

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…Allergies to cats are the most common mammalian‐origin allergy in humans and affect approximately 1 in 5 adults worldwide . Fel d 1 is the major cat allergen, accounting for up to 96% of human allergic sensitization to cats and 60%‐90% of the overall antigenicity of cats and cat dander …”

Section: Introductionmentioning

confidence: 99%

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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Background Allergies to cats are the most common animal‐origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component‐resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next‐generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance. Methods and Results This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen. Discussion The authors present the scientific basis of a novel care pathway that utilizes anti‐Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure. Conclusion Efficacy of a feline diet with an egg product ingredient containing anti‐Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat‐allergic human participants.

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Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

See 1 more Smart Citation

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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“…After mites and pollens, animals are the third leading cause of allergic asthma. The recommendations for the diagnosis and treatment of dog and cat allergies have been recently reviewed in a consensus document prepared using the RAND/UCLA Appropriateness Method …”

Section: Asthma Treatmentmentioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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“…1 It is estimated that 27% of European adults coming to the clinic for suspected allergy to inhalant allergens are sensitized to dogs, 2 and mammal epithelia are the third cause of rhinitis and asthma after dust mites and pollen in Spain. The amount of registered dogs in our country arises up to over 5 million, and they are currently the main pet.…”

mentioning

confidence: 99%