Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

Attie, Kenneth M.; Bengtsson, Bengt; Blethen, Sandra L.; Blum, Werner; Cameron, Fergus; Carel, Jean Claude; Carlsson, Lena; Chipman, John J.; Christiansen, Jens Sandahl; Clayton, Peter E.; Clemmons, David R.; Cohen, Pinchas; Drop, Stenvert L. S.; Fukui, Kenji; Ghigo, Ezio; Hintz, Raymond L.; Ho, Ken K. Y.; Ilondo, Mbelenge Mapoko; Jásper, H; Jesussek, Bernd; Kappelgaard, Anne-Marie; Laron, Zvi; Lippe, Barbara M.; Malozowski, Saúl; Mullis, Primus Ε.; Muinck-Keizer-Schrama, Sabine De; Nishi, Yoshikazu; Parks, John S.; Phelps, Charlotte; Ranke, Michael B.; Robinson, Iain C. A. F.; Rosenfeld, Ron G.; Rose, Susan R.; Saenger, Paul; Saggese, G; Savage, Martin O.; Shalet, Stephen M; Sizonenko, Pierre C.; Strasburger, Christian J.; Tachibana, Kunihide; Tanaka, Toshiaki; Thorner, Michael O.; Wikland, Kerstin Albertsson; Zadik, Zvi

doi:10.1210/jc.85.11.3990

Cited by 449 publications

(283 citation statements)

References 4 publications

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“…The interpretation of the stimulation tests were based on current consensus guidelines (14,15). The criteria for patients without stimulation tests were based on data from studies in patients with previous radiotherapy (16), with two or more additional pituitary hormone deficiencies (17), and with insulin-like growth factor-I (IGF-I) below K2S.D.…”

Section: Methodsmentioning

confidence: 99%

“…The criteria for patients without stimulation tests were based on data from studies in patients with previous radiotherapy (16), with two or more additional pituitary hormone deficiencies (17), and with insulin-like growth factor-I (IGF-I) below K2S.D. (15), showing that such patients with high probability also suffer from GHD. It is important to stress that the diagnosis GHD was only applied when the clinical context was relevant, in order to minimize the inclusion of false-positive persons.…”

Section: Methodsmentioning

confidence: 99%

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Morbidity and GH deficiency: a nationwide study.

Stochholm

Laursen

Green

et al. 2008

European Journal of Endocrinology

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Objective: To estimate morbidity in Denmark in all patients with GH deficiency (GHD). Design: Morbidity was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in the GHD patients were studied and additional morbidity noted. Diagnoses and dates of admissions were identified in the National Patient Registry. Lag time until first admission was used as a measure of morbidity. Patients were divided into childhood onset (CO) and adult onset (AO), discriminated by an age cut-off of 18 years at onset of GHD. Method: Sex-and cause-specific hazard ratios (HRs) in CO and AO GHD compared with controls. Results: Total morbidity was significantly increased in the GHD patients. HR for CO males: 3.1 (95% confidence interval (CI): 2.7-3.7), CO females: 3.2 (95% CI: 2.6-3.9), AO males: 2.9 (95% CI: 2.6-3.2), and AO females: 3.2 (95% CI: 2.8-3.6). In 18 out of 20 chapters from the International Classification of Diseases-10, a significantly increased morbidity was identified for at least one of the four subgroups of patients. Morbidity was significantly increased in all the four subgroups due to infectious, endocrine, pulmonary, urogenital, and neurological diseases; cancer; diseases of the eye, ear, and circulatory diseases; and traumas. Fractures were significantly increased in AO females, not in males.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Morbidity and GH deficiency: a nationwide study.

Stochholm

Laursen

Green

et al. 2008

European Journal of Endocrinology

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“…6 Other disorders of the pituitary gland DE23. 7 Other disorders of the pituitary gland, unspecified DE34. 3 Short stature, not elsewhere classified DE89.…”

Section: Methodsmentioning

confidence: 99%

“…All departments with registrations gave permission to read the records. Criteria for the diagnosis GHD were chosen based on published guidelines (7,8) with modifications (9-11), see Table 2. If necessary two or more departments were visited in order to find relevant and sufficient data about each case.…”

Section: Methodsmentioning

confidence: 99%

Incidence of GH deficiency – a nationwide study

Stochholm¹,

Gravholt²,

Laursen³

et al. 2006

eur j endocrinol

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Objective: Data on incidence rates are scarce in GH deficiency (GHD). Here, we estimate the incidence rate in childhood onset (CO) and adult onset (AO) GHD in Denmark. Design: We used three national registries to identify 9131 cases with an increased risk of GHD. Date of entry was defined using the date when a registration had taken place and when a date of sufficient information could be defined from a thorough examination of a record of a GHD patient, which ever came last. We considered date of entry as the incident date. Methods: Sex-specific incidence rates of GHD in children and adults using the background population as reference. Results: During 1980-1999, 1823 patients were incident. Three-hundred and three males and 191 females had CO, 744 males and 585 females had AO GHD. The incidence rate over time was stable for females with AO GHD and increasing for the other three subgroups. Average incidence rate for CO males, 2.58 (95% confidence interval (CI), 2.30-2.88), CO females, 1.70 (95% CI, 1.48-1.96), AO males, 1.90 (95% CI, 1.77-2.04), and AO females, 1.42 (95% CI, 1.31-1.54) all per 100 000. The incidence rate was significantly higher in males compared to females in the CO GHD group (P!0.001) and in the AO GHD group in the age ranges of 45-64 and 65C years (P!0.001). There was no significant difference in the 18-44 years age group. Conclusions: In conclusion, we have identified the incidence rates of GHD in a nationwide study of Denmark. In this population-based study, we have identified in CO GHD and in the two oldest age groups of AO GHD, a statistically significant higher incidence rate in males when compared with females.European Journal of Endocrinology 155 61-71

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“…Esta diferença em relação aos dados descritos na literatura mundial pode ser resultado de uma diferença étnica regional ou pode ser justificada pelo critério diagnóstico de DIGH adotado pelo nosso grupo. Em nosso serviço utilizamos como critério para o diagnóstico de DIGH um do pico de GH em teste de estímulo inferior a 3,3 µg/L (9) , em contraste com a literatura que descreve a utilização do valor de GH menor que 7 a 10 µg/L no teste de liberação para definir um pico de GH insuficiente (10) . Portanto, pacientes com mutações no GH1 com herança autossômica dominante poderiam estar sendo erroneamente diagnosticados como portadores de baixa estatura idiopática (BEI) ou familiar em nosso serviço, visto que estes poderiam apresentar secreção de GH entre 3,3 a 10 µg/L nos testes de estímulo (11) .…”

Section: Dados Internacionais De Catalogação Na Publicação (Cip)unclassified

Estudo do gene do hormônio de crescimento hipofisário (GH1) em indivíduos com baixa estatura idiopática

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Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

Cited by 449 publications

References 4 publications

Morbidity and GH deficiency: a nationwide study.

Morbidity and GH deficiency: a nationwide study.

Incidence of GH deficiency – a nationwide study

Estudo do gene do hormônio de crescimento hipofisário (GH1) em indivíduos com baixa estatura idiopática

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