Consensus guidelines on management of childhood convulsive status epilepticus

Mishra, Devendra; Sharma, Suvasini; Sankhyan, Naveen; Konanki, Ramesh; Kamate, Mahesh; Kanhere, Sujata; Aneja, Satinder

doi:10.1007/s13312-014-0543-4

Cited by 43 publications

(45 citation statements)

References 99 publications

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“…In a comparative study in children, it was reported as effective as valproate and safer in the control of refractory SE 13 . Review of literature shows that use of LEV is considered safe and effective in children with refractory SE [13][14][15] . In a report of two years' experience with this drug in SE, no severe adverse reactions were observed 16 .…”

Section: Discussionmentioning

confidence: 99%

Use of levetiracetam in pediatric refractory status epilepticus

Shakya

Bhatta

Phuyal

et al. 2019

J. Kathmandu Med. Coll.

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Refractory status epilepticus, with persistence of seizures despite initial intravenous benzodiazepine and one secondline intravenous antiepileptic drug occurs in nine percent to 44% of the patients with status epilepticus. Aggressive treatment is needed to control such seizures with drug refractoriness. A case of a 2-year-old boy treated with intravenous levetiracetam with cessation of seizures, averting the need for general anesthesia is reported. Option of using levetiracetam in refractory status epilepticus is suggested.

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Section: Discussionmentioning

confidence: 99%

Use of levetiracetam in pediatric refractory status epilepticus

Shakya

Bhatta

Phuyal

et al. 2019

J. Kathmandu Med. Coll.

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“…Even though generalized convulsive status epilepticus in adults and older children >5years refers to more than 5 min of continuous seizures or two or more discrete seizures between which there is incomplete recovery of consciousness, in view of most previous studies on status epilepticus having been done using the 30 minute definition, this study also has been done using 30 minutes definition. 3 Prolonged or refractory status epileptius is defined as seizures that persist despite the administration of two appropriate anticonvulsants at acceptable doses, with a minimum duration of status of 60 minutes (by history or in observation). 3 Shock and indication for intubation are defined according to PALS Guidelines.…”

Section: Methodsmentioning

confidence: 99%

“…3 Prolonged or refractory status epileptius is defined as seizures that persist despite the administration of two appropriate anticonvulsants at acceptable doses, with a minimum duration of status of 60 minutes (by history or in observation). 3 Shock and indication for intubation are defined according to PALS Guidelines.…”

Section: Methodsmentioning

confidence: 99%

Convulsive status epilepticus in children

Jagannathan¹,

Palanivelu²

2017

Int J Contemp Pediatr

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Background: Present study was undertaken to study the clinical profile, immediate outcome and possible risk factors for mortality in children with convulsive status epilepticus, admitted in pediatric intensive care unit in a tertiary care centre.Methods: This retrospective descriptive study included children between 1 month and 12 years of age admitted in pediatric intensive care unit with convulsive status epilepticus from April 2016 to March 2017. They were evaluated for their clinical presentation, laboratory parameters and immediate outcome. Data were gathered on 52 patients with convulsive status epilepticus. Factors were analysed using univariate and multivariate analyses.Results: Among the 52 patients, the observations made were, common age group1-5years (51%), males (63%), wih fever (62%), idiopathic seizures (41.5%), febrile status epilepticus (22.7%) abnormal eeg (9.4%), leuocytosis (54.7%), csf abnormalities (33%), prolonged seizures (33%), need for intubation (31%), shock (29%), mortality (9.4%).Conclusions: Clinical profile of children with convulsive status epilepticus is described. Presence of shock, need for intubation and prolonged seizures are significantly associated with mortality.

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“…3 The use of operational definition allows early treatment before the seizure becomes refractory to antiepileptic drugs. 4 Prolonged status epilepticus can lead to various complications such as cardiac dysrhythmia, metabolic derangements, autonomic dysfunction, neurogenic pulmonary oedema, hyperthermia, pulmonary aspiration and even permanent neurological damage. Approximately 4-10% of children experience one episode of seizure within first 16 years of life.…”

Section: Introductionmentioning

confidence: 99%

“…In view of this, the 'Multi-disciplinary Group on Management of Status Epilepticus in Children in India' in a consensus guideline has highlighted the need for research on epidemiology and outcome of SE in Indian children. 4 This study was undertaken as an attempt to describe clinical profile and outcome of children with convulsive status epilepticus presenting to pediatric intensive care unit (PICU) in a tertiary care hospital.…”

Section: Introductionmentioning

confidence: 99%

Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

Madhu

Krithika

2019

Int J Contemp Pediatr

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Background: The outcome of status epilepticus (SE) depends on various determinants such as age, type and duration of SE, etiology, management and associated comorbidities. This study was undertaken to describe the clinical profile and outcome of children with convulsive status epilepticus presenting to pediatric intensive care unit (PICU).Methods: Eighty-seven children between the age group 1 month to 12 years who at presentation or during the PICU stay had convulsive status epilepticus (CSE) were included in the study. Clinical profile, etiological spectrum and outcome at the end of hospital stay were analysed.Results: Median age of CSE was 4 years and 55 (63.2%) were below 5 years of age. Acute symptomatic etiology of CSE was a significant risk factor (p= 0.03) for refractory status epilepticus (RSE) which was seen in 31 patients (39%). Acute symptomatic etiology was the cause of CSE in 46 (59.2%) children. Remote symptomatic (26.4%), cryptogenic (18.4%) and progressive (2.3%) were other etiologies. Neuro-infection (29.8%) and febrile seizures (11.5%) were the most common acute symptomatic causes. Mortality and morbidity occurred in 23 (26.4%) and 8 (9.2%) patients respectively. Remaining 56 (64.6%) returned to baseline condition at the end of hospital stay. Longer duration (p= 0.03) and acute symptomatic etiology (p=0.049) were significant risk factors for mortality.Conclusions: Most common causes of CSE in children are acute symptomatic. Longer duration of status is associated with higher mortality. Hence, termination of seizure activity at the earliest, prudent management of respiratory or circulatory impairments in these children and improving the overall health care to prevent neuro-infections are important steps to improve outcome.

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Consensus guidelines on management of childhood convulsive status epilepticus

Cited by 43 publications

References 99 publications

Use of levetiracetam in pediatric refractory status epilepticus

Use of levetiracetam in pediatric refractory status epilepticus

Convulsive status epilepticus in children

Convulsive status epilepticus in children: clinical profile and outcome in a tertiary care hospital

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