Consensus on the application of negative pressure wound therapy of diabetic foot wounds

Ji, Shizhao; Liu, Xiaobin; Huang, Jie; Bao, Junmin; Chen, Zhaohong; Han, Chunmao; Hao, Daifeng; Hong, Jing-Song; Hu, Dahai; Jiang, Yufeng; Ju, Shang; Li, Hongye; Li, Zongyu; Liang, Guangping; Liu, Yan; Luo, Gaoxing; Lv, Guozhong; Ran, Xingwu; Shi, Zhongmin; Tang, Juyu; Wang, Aiping; Wang, Guangyi; Wang, Xin; Wen, Bing; Wu, Jun; Xu, Hailin; Xu, Mingsheng; Ye, Xiaofei; Yuan, Liangxi; Zhang, Yi; Xiao, Shichu; Xia, Zenan

doi:10.1093/burnst/tkab018

Cited by 39 publications

(33 citation statements)

References 145 publications

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“…Negative pressure wound therapy (NPWT) is one of the most effective techniques for the treatment of foot wounds. Although some advancements in this technique have been achieved, due to the complex pathogenesis and management of diabetic foot, irregular application of NPWT has been linked to complications, such as infections, bleeding and necrosis that seriously affect its treatment outcomes [45]. Based on the aforementioned information, it is apparent that several different approaches are available for the healing of foot ulcers, however their efficacy is dependent on an adequate arterial perfusion [46].…”

Section: Discussionmentioning

confidence: 99%

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

et al. 2021

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Ineffective healing and treatment of foot ulcers can lead to an infection and gangrene of the wound area that ultimately results in the loss of the limb. The incidence of foot ulcers is higher in patients with diabetes, peripheral vascular disease and kidney disease. Accordingly, this study was undertaken to assess the ability of foot bathing in CO2-enriched water to heal foot ulcers. The design was a double-blinded, randomized, placebo-controlled study. Patients with at least one foot ulcer were randomized to receive either a treatment with bath therapy at 37 ± 0.5 °C containing either 1000–1200 ppm CO2-enriched tap water (the intervention) or non-carbonated tap water at 37 ± 0.5 °C (the control group). Treatment was conducted three times/week for 15 min per session for up to 16 weeks for a total of 48 treatment sessions. Before and at the end of every treatment month, wound size, wound area oxygenation and the ankle brachial index were measured. In addition, the McGill pain questionnaire was conducted. Blood was also collected at these time points (for a total of five collections) for the measurement of different biomarkers. While no significant differences (p < 0.05) in the group/time interaction effect were observed, a clear separation within the wound area reduction/wound area/oxygenated Hb outcomes was seen between placebo (control) and treatment (CO2) group. This pilot study is suggestive that bathing in CO2-enriched water may accelerate the healing of foot ulcers.

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Section: Discussionmentioning

confidence: 99%

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

et al. 2021

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“…Auf Wunden, in denen aufgrund eines unvollständigen Débridements noch nekrotisches Gewebe verblieben ist, sollten NPWT-Verbände ebenfalls nicht angewandt werden. In diesem Falle ist eine ausreichende chirurgische Wundtoilette der Unterdrucktherapie voranzustellen [7].…”

Section: Kontraindikationenunclassified

“…Die zu erreichenden Therapieziele sollten vor jeder Anwendung von NPWT-Verbänden für jeden Patienten definiert werden [7]. Zu diesen Zielen zählen häufig ▪ die Kontrolle bzw.…”

Section: Therapiezieleunclassified

“…Da der Wechsel der Vakuumverbände auch unter sterilen Kautelen außerhalb des Operationssaals und gegebenenfalls auch im ambulanten Setting durchgeführt werden kann, sollte alle 1-2 NPWT-Zyklen eine Reevaluation der Therapie durch einen Chirurgen durchgeführt werden [7] [11]. Die Autoren dieser Studie geben an, dass pro cm 3 Reduktion der Wundfläche Kosten von 30,92 US-Dollar/cm 3 bei konventionellen und 11,90 US-Dollar/cm 3…”

Section: Therapiezieleunclassified

“…TAKE HOME MESSAGEAus den oben aufgeführten Indikationen und Kontraindikationen lassen sich Voraussetzungen ableiten, welche vor NPWT-Applikation erfüllt sein sollten[7]: ▪ Die Wunde ist chirurgisch debridiert, nekrotisches Gewebe wurde entfernt, und das Infektionspotenzial ist kontrolliert. ▪ Es liegen keine aktiven Blutungsquellen vor.…”

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Unterdrucktherapie, Negative Pressure Wound Therapy (NPWT)

Diehm¹,

Reiter²,

Bigdeli³

et al. 2022

Orthopädie und Unfallchirurgie up2date

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Magnetic Field‐Directed Deep Thermal Therapy via Double‐Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds

He,

Liu,

Jia

et al. 2023

Adv Funct Materials

Self Cite

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Although near‐infrared (NIR) light‐based photothermal therapies have shown therapeutic potential for infected wounds, the attenuation of NIR light intensity in tissue has severely limited the usage in deep bacterial infections. Herein, magneto‐thermal responsive bilayer microneedles (Fe‐Se‐HA MNs) consisting of functionalized hyaluronic acid (HA), ferro‐ferric oxide (Fe3O4), and micelle‐protected selenium nanoparticles (SeNPs@LAS) are constructed to overcome this challenge based on a self‐designed disk‐shaped electromagnetic field device (Disk‐ZVS). The electromagnetic field generated by the Disk‐ZVS shows virtually no intensity attenuation in living tissue. Finite element simulations showed that the field intensity and electromagnetic loss are concentrated on the tips of Fe‐Se‐HA MNs. The MNs are able to puncture hard scabs, penetrate into bacterial biofilms, and perform effective magnetic‐thermal conversion for deep hyperthermia sterilization. Following, the Fe‐Se‐HA MNs can be gradually degraded by excessive hyaluronidase in diabetic wound to release SeNPs, which reduce reactive oxygen species (ROS) to regulate wound redox homeostasis. Meanwhile, the SeNPs are beneficial to angiogenesis, which facilitates blood vessel formation and promotes wound repair. Therefore, various functions can be achieved for the Fe‐Se‐HA MNs, such as magneto‐thermal disinfection, deep and non‐invasive tissue penetration, anti‐inflammation, and pro‐angiogenesis, which shows great potential as an adjunctive therapy for infected diabetic wounds.

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Consensus on the application of negative pressure wound therapy of diabetic foot wounds

Cited by 39 publications

References 145 publications

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

Unterdrucktherapie, Negative Pressure Wound Therapy (NPWT)

Magnetic Field‐Directed Deep Thermal Therapy via Double‐Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds

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