Consensus Report From the Stockholm Pediatric Proton Therapy Conference

Indelicato, Daniel J.; Merchant, Thomas E.; Laperrière, Normand; Lassen, Y.; Vennarini, Sabina; Wolden, Suzanne L.; Hartsell, William F.; Pankuch, Mark; Brandal, Petter; Law, Chi Ching; Taylor, Roger; Laskar, Siddhartha; Okcu, M. Fatih; Bouffet, Éric; Mandeville, Henry; Björk‐Eriksson, Thomas; Nilsson, Kristina; Nyström, Håkan; Constine, Louis S.; Story, Michael D.; Timmermann, Beate; Roberts, Kenneth B.; Kortmann, Rolf Dieter

doi:10.1016/j.ijrobp.2016.06.2446

Cited by 52 publications

(37 citation statements)

References 8 publications

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“…Thus, the indication for this treatment modality should be discussed with the same caution as for conventional radiation therapy. ▪ In case of advantages in comparison to conventional therapy with respect to dose to organs at risk, or if the patient is very young, proton beam therapy (as treatment technique) may be recommended if irradiation is indicated in a child with LGG [57].…”

Section: Proton Beam Therapymentioning

confidence: 99%

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

et al. 2019

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Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors of WHO grades I and II occurring throughout all pediatric age groups and at all central nervous system (CNS) sites. The tumors are characterized by a slow growth rate and may show periods of growth arrest. Around 40% of all LGG patients can be cured by complete neurosurgical resection and are followed by close observation. In case of relapse, second resection often is possible. Following incomplete resection observation is recommended, as long as there is no radiologic tumor growth and the patient does not suffer from significant, tumor-related symptoms. This also applies to patients with a diagnosis of LGG on the basis of radiological criteria. By contrast, clinical worsening and / or radiologic progression are an indication to treatment with either chemo- or radiotherapy. Overall survival is around 90%, and many patients survive with residual tumor, i. e. they suffer from chronic disease. All patients need comprehensive neuro-oncological care, the principles and details of which are summarized in the current guidelines. These represent standard of care for diagnostic work-up (including neuroimaging and neuropathology), and for therapeutic decisions (including the indications to non-surgical treatment) as well as concepts for neurosurgical intervention, chemotherapy and radiotherapy as well as surveillance and rehabilitation. The current treatment algorithm was compiled by members of the LGG working group of the SIOP-E brain tumor group (SIOP-E-BTG) and is based upon the results of previous European LGG studies and international reports.

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Section: Proton Beam Therapymentioning

confidence: 99%

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

et al. 2019

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“…With the improvement of survival rates of pediatric patients with GCT, the long‐term side effects of treatment are of increasing importance, especially the late toxicities of normal tissue exposure to radiation. In efforts to decrease radiation toxicity, there has been an increase in the use of proton therapy for pediatric tumors . In brain tumors requiring focal radiation, proton therapy can reduce the dose to the cochlea and hypothalamus, lessening the long‐term impact of radiation on cognitive functioning .…”

Section: Discussionmentioning

confidence: 99%

Early outcomes and patterns of failure following proton therapy for nonmetastatic intracranial nongerminomatous germ cell tumors

Mokhtech

Rotondo

Bradley

et al. 2018

Pediatric Blood & Cancer

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“…Allen et al [5] evidenced the benefit of PBT over photon treatments for pediatric Central Nervous System (CNS) tumors and other malignancies, but they underlined that existing data were still limited to provide conclusive recommendations for pediatric non-CNS tumors. In the Consensus Report from the Stockholm Pediatric Proton Therapy Conference published in 2016 [16], expert opinions on current indications for PBT in pediatrics confirmed that the majority of pediatric cancers which require RT should be treated with PBT. Protons were assumed as a preferred indication for most common pediatric CNS tumors, as well as for skull base tumors and retinoblastoma [16].…”

Section: Introductionmentioning

confidence: 99%

Proton therapy in the most common pediatric non-central nervous system malignancies: an overview of clinical and dosimetric outcomes

et al. 2019

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Radiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PBT) – is of great interest. In particular, potential radiation-induced injuries and secondary malignancies – also associated to the prolonged life expectancy of patients – are still questions of concern that increase the debate on the usefulness of PBT in pediatric treatments. This paper presents a literary review of current applications of PBT in non-Central Nervous System pediatric tumors (such as retinoblastoma, Hodgkin Lymphoma, Wilms tumor, bone and soft tissues sarcomas). We specifically reported clinical results achieved with PBT and dosimetric comparisons between PBT and the most common photon-therapy techniques. The analysis emphasizes that PBT minimizes radiation doses to healthy growing organs, suggesting for reduced risks of late side-effects and radiation-induced secondary malignancies. Extended follow up and confirms by prospective clinical trials should support the effectiveness and long-term tolerance of PBT in the considered setting.

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Consensus Report From the Stockholm Pediatric Proton Therapy Conference

Abstract: 2016-11-03T14:11:40

Cited by 52 publications

References 8 publications

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

Early outcomes and patterns of failure following proton therapy for nonmetastatic intracranial nongerminomatous germ cell tumors

Proton therapy in the most common pediatric non-central nervous system malignancies: an overview of clinical and dosimetric outcomes

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