Consensus statement from the consensus conference on blood‐borne human immunodeficiency virus and hepatitis: optimizing the donor‐selection process

King, Susan; AuBuchon, James P.; Barrowman, Nicholas J.; Folléa, Gilles; Giroux, Michael J.; Kim, W.; Kreppner, J.; Millson, Peggy; Squires, Bruce P.; Shaul, Randi Zlotnik

doi:10.1046/j.1423-0410.2002.00214.x

Cited by 8 publications

(10 citation statements)

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“…The 241 adults enrolled were primarily men (63%), median age was 28 years (interquartile range [IQR] 25-34), 73% had a postsecondary school level education, and half were unemployed ( Table 1). The median time between the last HIVnegative test and the first HIV-positive test was 7 months (IQR, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The median time from the estimated date of seroconversion to enrollment in the cohort was 9 months (IQR, 5-18).…”

Section: Resultsmentioning

confidence: 99%

“…In this context where most first‐time blood donors are unaware of their HIV status, the residual risk of HIV transmission from blood products in the Abidjan National Blood Transfusion Center was estimated to be 1 in 5780 blood donations in the period 2002 through 2004 8 . The prevention of HIV transmission through blood products includes the limitation of transfusions to strictly indicated cases; the fact that blood donors are volunteer, selected, and educated; and that blood is systematically screened for HIV antibodies 9 . Donor selection uses structured questionnaires to exclude recently infected donors at high risk of HIV transmission, that is, donors who may be in the window period of infection before the apparition of HIV antibodies or whose recent HIV infection may not have been detected by the standard serologic screening techniques used at the blood transfusion center.…”

mentioning

confidence: 99%

“…8 The prevention of HIV transmission through blood products includes the limitation of transfusions to strictly indicated cases; the fact that blood donors are volunteer, selected, and educated; and that blood is systematically screened for HIV antibodies. 9 Donor selection uses structured questionnaires to exclude recently infected donors at high risk of HIV transmission, that is, donors who may be in the window period of infection before the apparition of HIV antibodies or whose recent HIV infection may not have been detected by the standard serologic screening techniques used at the blood transfusion center. This step is particularly crucial in a context of high prevalence of HIV infection like in Ivory Coast.…”

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confidence: 99%

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Risk behaviors in volunteer blood donors who seroconverted for HIV, Abidjan, Côte d'Ivoire 1997 to 2005

et al. 2010

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BACKGROUND: The residual risk of human immunodeficiency virus (HIV) transmission from blood products in the Abidjan National Blood Transfusion Center was estimated to be 1 in 5780 blood donations over the period 2002 through 2004. We aimed at describing risk behaviors in blood donors who seroconverted for HIV in Abidjan to improve the pre–blood donation selection. STUDY DESIGN AND METHODS: We investigated the behavioral profile of HIV seroconverters assessed before their HIV diagnosis, during the blood donation selection at the blood bank of Abidjan, and compared it to the profile documented after this HIV diagnosis, at enrollment in the PRIMO‐CI cohort. Since 1997, enrollment in this cohort is offered to every blood donor whose delay since HIV seroconversion was 36 months or less. RESULTS: Among the 418 blood donors who seroconverted for HIV between 1997 and 2005, 241 were enrolled in the cohort. Median age was 28 years and 63% were men. The median time between the last HIV‐negative test and the first positive test was 7 months. Since the last blood donation, 29% of donors reported unprotected sexual intercourse with multiple casual sexual partners, 55% unprotected sexual intercourse with one casual sexual partner, and 36% sharing of nail clippers. During the pre–blood donation questionnaire, 69% of HIV seroconverters had reported unprotected sexual intercourse since the last blood donation (vs. 89% reported after donation), and 7% had had multiple casual sexual partners (vs. 32%). CONCLUSION: Volunteer blood donors who seroconverted for HIV in Abidjan reported a high proportion of unprotected sexual intercourse with casual sexual partners.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Risk behaviors in volunteer blood donors who seroconverted for HIV, Abidjan, Côte d'Ivoire 1997 to 2005

et al. 2010

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“…There is likely no simplistic threshold for blood safety risk that may be applied in each RBDM analysis: ‘Risk perception is complex, and consequently, there is probably no single acceptable level of risk with regard to TTI's’ . However, as has often been demonstrated, a transparent, collaborative, multi‐disciplinary, systematic process for review of all of these decision factors remains a principled approach with which to address challenging risk issues such as pathogen risks , non‐infectious risks of transfusion , donor deferral and emerging technologies . The practice of RBDM is not an instant remedy for multi‐faceted risk issues but it is a ‘pathway’ for structuring and supporting required data collection, analysis and decision making .…”

Section: Discussionmentioning

confidence: 99%

Risk‐based decision making in transfusion medicine

Bennett

Devine

2018

Vox Sanguinis

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Formal processes to assess risk are well established in numerous areas of society including the environment, transportation, energy and food production sectors as well as some areas of health care such as new drugs or other therapeutic goods. However, these processes and their associated frameworks have only recently come to be used to make decisions in blood transfusion practice or in blood system policy development. This review describes the evolution of the use of risk-based decision making and discusses the elements that should be considered in its application to blood system issues. Following the identification and characterization of the risk, a structured process is undertaken to assess the magnitude of the risk and the level of risk reduction that can reasonably be achieved in the context of the complexity of the risk management action proposed and its cost. Inputs must be sought from appropriate subject matter experts, but also from those who can consider issues of ethics and social values. Engagement of the public is an essential step. Proposed interventions should be assessed for their likelihood of mitigating the risk and the proportional resource allocation in comparison with similar risks to the blood system or health system. Examples are provided of how a risk-based decision-making framework is used to address identified risks in the blood system.

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“…The goal of the donor health assessment questionnaire (DHAQ) is to ensure that blood donation is safe for both the donor and the recipient 1‐3 . Since its origin in the early 1980s, the Canadian DHAQ has grown over time, with questions added primarily to satisfy regulatory requirements or address emerging threats.…”

mentioning

confidence: 99%

The donor health assessment questionnaire: potential for format change and computer‐assisted self‐interviews to improve donor attention

Goldman

Ram

et al. 2007

Transfusion

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Consensus statement from the consensus conference on blood‐borne human immunodeficiency virus and hepatitis: optimizing the donor‐selection process

Cited by 8 publications

References 2 publications

Risk behaviors in volunteer blood donors who seroconverted for HIV, Abidjan, Côte d'Ivoire 1997 to 2005

Risk behaviors in volunteer blood donors who seroconverted for HIV, Abidjan, Côte d'Ivoire 1997 to 2005

Risk‐based decision making in transfusion medicine

The donor health assessment questionnaire: potential for format change and computer‐assisted self‐interviews to improve donor attention

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