Consensus Statement on the Management of Paediatric Asthma

Monge, Rosa María Busquets; Montaner, Amparo Escribano; Benítez, M. Fernández; García‐Marcos, Luis; Garde, J.; Iborra, M. Ibero; Rocamora, L. Pardos; Jiménez, J. Sánchez; Sánchez, Eduardo Sánchez; Ortega, J. Sanz; Asensi, José Ramón Villa

doi:10.1157/13088174

Cited by 10 publications

(2 citation statements)

References 104 publications

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“…3 With this in mind, various clinical guidelines for childhood asthma have recently been developed in different countries. [5][6][7] One of the requirements of these guidelines is the need to assess the level of asthma control. Questionnaires such as the ''Asthma Control Questionnaire'' (ACQ) 8 and the ''Asthma Control Test'' (ACT) 9 have been developed to evaluate the perception of disease control from the patient's point of view in adult populations.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a questionnaire to assess asthma control in pediatrics

Pérez-Yarza

Badı́a²,

Badiola

et al. 2008

Pediatric Pulmonology

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on behalf of the CAN Investigator Group { Summary. Objective: To develop and validate a questionnaire to assess asthma control in children (CAN). Design: Two versions of the CAN (for carers and children) were developed. Both versions were validated in an observational, prospective, multicenter study performed in 38 hospital outpatient clinics throughout Spain. Four hundred fifteen patients and their carers agreed to participate. Of these, 414 patients under 14 years old with frequent episodic or persistent (moderate to severe) asthma completed the questionnaire on 3 occasions (baseline, week 2, and week 12). For patients aged 2-8 the questionnaire was only completed by the carers, but for patients aged 9-14 the questionnaire was completed by the carers and the children. Clinician ratings of asthma control were used as a gold standard to assess the sensitivity, specificity, PPV and NPV of the new measure. Results: Evaluable responses were obtained from 215 carers for children aged 2-8 years and 199 children aged 9-14 years, and their parents. Using a questionnaire total score cut-off of 8 the patient version had a sensitivity of 76.3% and a specificity of 62.9%. For carer version these values were 73% and 69.7%, respectively. A cut point of 8 was selected to maximize the screening accuracy of the CAN questionnaire. Effect sizes in patients with clinician-rated improvements in asthma control were 0.33 and 0.57 for the carer and child versions, respectively. Conclusions: The screening accuracy and validity of the CAN questionnaire make it suitable for use in research and clinical practice. The sensitivity and specificity were close to 70%, which is acceptable for the study objective: obtain a tool to measure the level of asthma control.

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Section: Introductionmentioning

confidence: 99%

Development and validation of a questionnaire to assess asthma control in pediatrics

Pérez-Yarza

Badı́a²,

Badiola

et al. 2008

Pediatric Pulmonology

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“…Wheezing has been reported in approximately 50% of preschool children, and although most cases are attributed to viral illness, 1 recurrent wheeze and persistence of wheeze symptoms through childhood have been strongly associated with adult asthma. 2,3 Early identification of preschool-aged children at risk for asthma is critical as we seek to prevent morbidity associated with chronic asthma, 4 such as long-term lung function decline. 5,6 Yet, asthma is a heterogeneous condition, and diagnosis can be challenging in children.…”

Section: Introductionmentioning

confidence: 99%

Lung clearance index predicts persistence of preschool wheeze

Safavi

Dai

Breton

et al. 2021

Pediatric Allergy Immunology

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Background The lung clearance index (LCI) is a measure of pulmonary function. Variable feasibility (50‐>80%) in preschool children has been reported. There are limited studies exploring its relationship to respiratory symptoms and how it predicts persistent wheeze. We aimed to assess the association with respiratory symptoms in preschool‐aged children with LCI and determine its utility in predicting persistent wheeze. Methods LCI was measured in a subcohort of the CHILD Cohort Study at age 3 years using SF6 multiple breath washout test mass spectrometry. Respiratory symptom phenotypes at age 3 were derived from children's respiratory symptoms reported by their parents. Responses were used to categorize children into 4 symptom groups: recurrent wheeze (3RW), recurrent cough (3RC), infrequent symptoms (IS), and no current symptoms (NCS). At age 5 years, these children were seen by a specialist clinician and assessed for persistent wheeze (PW). Results At age 3 years, 69% (234/340) had feasible LCI. Excluding two children with missing data, 232 participants were categorized as follows: 33 (14%) 3RW; 28 (12%) 3RC; 17 (7%) IS; and 154 (66%) NCS. LCI z‐score at age 3 years was highest in children with 3RW compared to 3RC (mean (SD): 1.14 (1.56) vs. 0.09 (0.95), p < .01), IS (mean (SD): −0.14 (0.59), p < .01), and NCS (mean (SD): −0.08 (1.06), p < .01). LCI z‐score at age 3 was predictive of persistent wheeze at age 5 (PW) (AUROC: 0.87). Conclusions LCI at age 3 was strongly associated with recurrent wheeze at age 3, and predictive of its persistence to age 5.

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Changes in IL-10 and specific antibodies associated to successful Dermatophagoides pteronyssinus immunotherapy in children during the first year of treatment

Martín-Muñoz¹,

Pineda²,

Muiños³

et al. 2013

Allergologia et Immunopathologia

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Thirty-eight children completed the study. At T1 all had rhinitis and 34 also had asthma. At T3, 30 patients had improved, six experienced no changes and two worsened. Improvement was associated to FEV1/FVC and VAS improvement; to a reduction in D. pteronyssinus skin prick test; to a progressive increase in serum levels of D. pteronyssinus IgE, and D. pteronyssinus, Der p1 and Der p2 IgG4. IL-10 levels showed an early increase at T2f (the end of initial build-up immunotherapy phase), and then a reduction at T3 (the end of a year of immunotherapy). Improvement associated to an early increase in IL-10 and was correlated with VAS and specific IgG4 evolution.

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Consensus Statement on the Management of Paediatric Asthma

Cited by 10 publications

References 104 publications

Development and validation of a questionnaire to assess asthma control in pediatrics

Development and validation of a questionnaire to assess asthma control in pediatrics

Lung clearance index predicts persistence of preschool wheeze

Changes in IL-10 and specific antibodies associated to successful Dermatophagoides pteronyssinus immunotherapy in children during the first year of treatment

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