Consensus workshop on advanced diagnostic andrology techniques. ESHRE Andrology Special Interest Group

Fraser, Lin; Barratt, Christopher L.R.; D, Canale; Cooper, T. B.; DeJonge, Christopher J.; Irvine, Stewart; Mortimer, David; Oehninger, Sergio; Tesařík, Jan

doi:10.1093/oxfordjournals.humrep.a019580

Cited by 17 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, 2006). Nevertheless, these bioassays were proven to be cumbersome, time‐consuming, expensive and depending on the availability of scarce human biological material (Fraser et al. , 1997).…”

Section: Introductionmentioning

confidence: 99%

Clinical management of male infertility in assisted reproduction: ICSI and beyond

Oehninger

2011

International Journal of Andrology

Self Cite

View full text Add to dashboard Cite

The advent of in vitro fertilization and its augmentation with intracytoplasmic sperm injection (ICSI) has allowed a large number of couples suffering from moderate to severe male infertility, and also presenting with female pathologies, to achieve their reproductive dreams. Notwithstanding the existence of fundamental questions about the pathophysiological mechanisms leading to sperm dysfunction, and still unanswered concerns about health risks following ICSI, it appears that overall ICSI is safe and here to stay. Although on one hand ICSI possibly hampered advances of the knowledge in some areas of gamete biology and interaction, on the other it definitely gave impulse to studies designed to unveil the sperm contributions during and beyond fertilization, including the normalcy of the DNA/chromatin as well as molecular mechanisms of genetic/epigenetic control and nuclear organization status. In all, almost entering the fourth decade of assisted reproductive technologies, we should continue monitoring the safety of the technique and long-term development of offspring, whereas at the same time prioritizing areas of research addressing these fundamental questions.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical management of male infertility in assisted reproduction: ICSI and beyond

Oehninger

2011

International Journal of Andrology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Categories of sperm function tests that have been studied in the clinical setting include the sperm-zona pellucida binding assays, the induced-acrosome reaction tests, and the assessment of motion parameters by computerized methods (25,26). However, only a handful of studies have addressed the role of such sperm function tests on the outcome of IUI (27)(28)(29).…”

mentioning

confidence: 99%

Predictive value of the hemizona assay for pregnancy outcome in patients undergoing controlled ovarian hyperstimulation with intrauterine insemination

Arslan

Morshedi

Arslan

et al. 2006

Fertility and Sterility

View full text Add to dashboard Cite

“…Since the ionophore challenge bypasses the biological signalling that initiates the AR, and uncapacitated spermatozoa respond poorly (93), this test is accepted as a measure of the capacitation status and the integrity of the chain of events between entry on calcium and exocytosis. Likewise, enhanced versions of the HEPT, including procedures which stimulate acrosome exocytosis (ionophore challenge or sperm preincubation at 4°C in TEST-yolk buffer) would have a higher biological and clinical efficacy (89).…”

Section: Effects On Sperm Capacitation Acrosome Reaction and Oocyte-mentioning

confidence: 99%

Naturally-occurring antisperm antibodies in men: interference with fertility and clinical implications. An update

Francavilla¹

2007

Front Biosci

View full text Add to dashboard Cite

Naturally-occurring anti-sperm antibodies (ASA) in men can affect fertility by various mechanisms. Some of them are mainly related to the extent of the sperm autoimmunization (e.g., sperm-agglutination and impaired cervical mucus penetration); others are also related to immunoglobulin (Ig)-isotype (e.g., complement-mediated sperm injury through the female genital tract), or to antigenic specificity of ASA (e.g., interference with gametes interaction). The unavailability of current diagnostic tests to determine the antigenic specificity of ASA, and the difficulty in quantifying the antibody density on the sperm surface make it hard to establish in each individual patient, whether, or to what extent, these interfering effects occur, apart from sperm-agglutination and the impairment of cervical mucus penetration. However, the rational use of current ASA-tests can be effective in screening and quantifying sperm autoimmunization relevant to infertility. The degree of sperm-autoimmunization is the only empirical (rather effective) criterion in choosing more or less invasive assisted reproductive techniques (ART) for couples, where male immunological infertility is diagnosed. A more rational treatment strategy would be possible with the development of tests detecting ASA directed against defined fertilization-related antigens. In this article, the growing knowledge in this field is reviewed.

show abstract

Consensus workshop on advanced diagnostic andrology techniques. ESHRE Andrology Special Interest Group

Cited by 17 publications

References 0 publications

Clinical management of male infertility in assisted reproduction: ICSI and beyond

Clinical management of male infertility in assisted reproduction: ICSI and beyond

Predictive value of the hemizona assay for pregnancy outcome in patients undergoing controlled ovarian hyperstimulation with intrauterine insemination

Naturally-occurring antisperm antibodies in men: interference with fertility and clinical implications. An update

Contact Info

Product

Resources

About