Consequences of brucellosis infection during pregnancy: A systematic review of the literature

Alsaif, Manal; Dabelah, Kamal; Featherstone, Robin; Robinson, Joan

doi:10.1016/j.ijid.2018.05.023

Cited by 19 publications

(14 citation statements)

References 42 publications

(55 reference statements)

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“…Early life is a critical developmental period, and experiences in this stage, i.e., embryonic stage and adolescence have been shown to have a long-term influence on developmental and aging processes ( Li X. Y. et al, 2016 ; Höltge et al, 2019 ). The embryonic period is associated with a greater vulnerability to bacterial and viral infections owing to an immature immune system ( Khan et al, 2017 ; Alsaif et al, 2018 ). It is well documented that pregnant animals have increased sensitivity to LPS than non-pregnant ones ( Kunnen et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Zhang

et al. 2020

Front. Aging Neurosci.

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Accumulating evidence has indicated that embryonic inflammation could accelerate age-associated cognitive impairment, which can be attributed to dysregulation of synaptic plasticity-associated proteins, such as RNA-binding proteins (RBPs). Staufen is a double-stranded RBP that plays a critical role in the modulation of synaptic plasticity and memory. However, relatively few studies have investigated how embryonic inflammation affects cognition and neurobiology during aging, or how the adolescent psychosocial environment affects inflammation-induced remote cognitive impairment. Consequently, the aim of this study was to investigate whether these adverse factors can induce changes in Staufen expression, and whether these changes are correlated with cognitive impairment. In our study, CD-1 mice were administered lipopolysaccharides (LPS, 50 µg/kg) or an equal amount of saline (control) intraperitoneally during days 15-17 of gestation. At 2 months of age, male offspring were randomly exposed to stress (S), an enriched environment (E), or not treated (CON) and then assigned to five groups: LPS, LPS+S, LPS+E, CON, and CON+S. Mice were evaluated at 3-month-old (young) and 15-month-old (middle-aged). Cognitive function was assessed using the Morris water maze test, while Staufen expression was examined at both the protein and mRNA level using immunohistochemistry/western blotting and RNAscope technology, respectively. The results showed that the middle-aged mice had worse cognitive performance and higher Staufen expression than young mice. Embryonic inflammation induced cognitive impairment and increased Staufen expression in the middle-aged mice, whereas adolescent stress/an enriched environment would accelerated/mitigated these effects. Meanwhile, Staufen expression was closely correlated with cognitive performance. Our findings suggested embryonic inflammation can accelerate age-associated learning and memory impairments, and these effects may be related to the Staufen expression.

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Section: Discussionmentioning

confidence: 99%

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Zhang

et al. 2020

Front. Aging Neurosci.

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“…Congenital brucellosis can be contracted transplacentally, whereas neonatal brucellosis can be acquired through the contact with body fluids secreted during delivery or by breastfeeding in the postpartum period [43,[56][57][58]. However, congenital brucellosis is a rare condition, most of the cases are associated with preterm delivery [55,59], and it occurs in approximately 2% of infants exposed to brucellosis in utero [60]. From 1988 to 2007, only 15 cases of congenital brucellosis were reported in the literature [55].…”

Section: Outcome For Infantsmentioning

confidence: 99%

“…Obstetric manifestations in women with brucellosis were vaginal bleeding in 9.1% (22 out of 242) [23], postpartum endometritis in 28.6% (2 out of 7) [30], groin pelvic pain in 23.5% (8 out of 34) [23], as well as preterm rupture of membranes [43,55,56] and chorioamnionitis [60,67]. Repeated abortions were also described among women with brucellosis [24,27], and one old report found infertility in 19% [10] but this was not further confirmed [24,27].…”

Section: Outcome For Pregnant Womenmentioning

confidence: 99%

Human brucellosis in pregnancy – an overview

Bosilkovski

Arapović

Keramat

2019

Bosn J of Basic Med Sci

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Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported to be 1.5–12.2% and 0.42–3.3, respectively. Depending on the region, frequency of pregnant women in the cohorts of patients with brucellosis was from 1.5% to 16.9%. The most common and the most dramatic unfavorable outcomes during brucellosis in pregnancy are the obstetric ones, manifested as abortions (2.5–54.5%), intrauterine fetal death (0–20.6%) or preterm deliveries (1.2–28.6%), depending on the stage of pregnancy. Other unfavorable outcomes due to brucellosis are addressed to infant (congenital/neonatal brucellosis, low birth weight, development delay or even death), the clinical course of disease in mother and delivery team exposure. When diagnosed in pregnant women, brucellosis should be treated as soon as possible. Early administration of adequate therapy significantly reduces the frequency of adverse outcomes. Rifampicin in combination with trimethoprim-sulfamethoxazole for 6 weeks is the most commonly used and recommended regimen, although monotherapies with each of these two drugs are also widely used while waiting for the results from prospective randomized therapeutic trials. As no effective human vaccine exists, screening of pregnant women and education of all women of childbearing age about brucellosis should be compulsory preventive measures in endemic regions.

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“…Although suspected, since the initial report of abortion of a farmer's wife in the 1900s (Eyre, ), pregnancy complications in infected women have long been underestimated. However, it is now recognised, with a growing number of epidemiological studies describing increased risks of adverse obstetric outcomes (preterm delivery, spontaneous abortion, fetal death, or low birthweight; Ali et al, ; Alsaif, Dabelah, Featherstone, & Robinson, ; Al‐Tawfiq & Memish, ; Elshamy & Ahmed, ; Giakoumelou et al, ; Gulsun, Aslan, Satici, & Gul, ; Kurdoglu et al, ; Mohammad, El Ghazaly, Zaalouk, Morsy, & El‐Ghazaly, ; Mujuni et al, ; Vilchez, Espinoza, D'Onadio, Saona, & Gotuzzo, ), arguing that brucellosis is a threat for pregnant women. Infection can also be transmitted to the fetus (congenital brucellosis), most probably through transplacental spreading (Alsaif, Dabelah, Girim, Featherstone, & Robinson, ; Aydin et al, ; Giannacopoulos, Eliopoulou, Ziambaras, & Papanastasiou, ; Glocwicz, Stonecipher, & Schulte, ; Koklu et al, ; Mesner et al, ; Poulou, Markou, Xipolitos, & Skandalakis, ; Vilchez et al, ), or to the neonate (neonatal brucellosis), upon exposure to maternal fluids during delivery (Carbajo‐Ferreira, Ochoa‐Sangrador, Canut‐Blasco, & Castaño‐García, ; Singer et al, ).…”

Section: Introductionmentioning

confidence: 99%

Infection by Brucella melitensis or Brucella papionis modifies essential physiological functions of human trophoblasts

García‐Méndez

Hielpos

Soler-Lloréns

et al. 2019

Cellular Microbiology

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Brucellosis is a zoonosis caused by bacteria of the Brucella genus. In ruminants, brucellosis causes abortion, followed by chronic infection and secretion of bacteria in milk. In humans, it usually presents as flu‐like symptoms, with serious complications if untreated. Epidemiological studies have only recently established that brucellosis can also cause pregnancy complications in women, but the pathogenic mechanisms are unknown. Pioneering studies in ruminants showed that Brucella infect trophoblasts and then colonise the placenta where they grow to high density. A recent study showed that the main zoonotic Brucella species can infect human cytotrophoblasts (CTB) and extravillous trophoblasts (EVT). In this work, we show that Brucella papionis (associated with stillbirth in primates) also infects human trophoblasts. However, it replicates actively in CTB, whereas its replication is very restricted within EVT. We also observed alteration of several trophoblastic functions upon infection by B. papionis or Brucella melitensis (the most prevalent species in human brucellosis). Infection altered the production of hormones, the ability of CTB to form syncytiotrophoblasts, and the invasion capacity of EVT. We also found that infection can spread between different types of trophoblasts. These findings constitute a new step in understanding how Brucella infection causes adverse pregnancy outcomes.

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Consequences of brucellosis infection during pregnancy: A systematic review of the literature

Abstract: Brucellosis almost certainly causes SA with increasing evidence that it also leads to IUFD and prematurity. Congenital brucellosis occurs in approximately 2% of infants exposed in-utero.

Cited by 19 publications

References 42 publications

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Human brucellosis in pregnancy – an overview

Infection by Brucella melitensis or Brucella papionis modifies essential physiological functions of human trophoblasts

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