Consequences of endocrine disrupting chemicals on reproductive endocrine function in birds: Establishing reliable end points of exposure

Ottinger, Mary Ann; Quinn, Michael J.; Lavoie, Emma T.; Abdelnabi, Mahmoud; Thompson, Nichola; Hazelton, Julie L.; Wu, Julie M.; Beavers, J.; Jaber, Mark

doi:10.1016/j.domaniend.2005.02.038

Cited by 53 publications

(33 citation statements)

References 38 publications

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“…If pollution from endocrine disrupting chemicals continues, it may be difficult for birds to escape some fitness reducing consequences (Halldin 2005;Ottinger et al 2005). How rapidly could a bird evolve resistance to environmental oestrogens without disrupting its normal sexual differentiation processes and essential egg production functions?…”

Section: The Sexual Differentiation Cascadesmentioning

confidence: 99%

Do hormonal control systems produce evolutionary inertia?

Adkins‐Regan

2007

Phil. Trans. R. Soc. B

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Hormonal control systems are complex in design and well integrated. Concern has been raised that these systems might act as evolutionary constraints when animals are subject to anthropogenic environmental change. Three systems are examined in vertebrates, especially birds, that are important for assessing this possibility: (i) the hypothalamic-pituitary-gonadal (HPG) axis, (ii) the activational effects of sex steroids on mating effort behaviour, and (iii) sexual differentiation. Consideration of how these systems actually work that takes adequate account of the brain's role and mechanisms suggests that the first two are unlikely to be impediments to evolution. The neural and molecular networks that regulate the HPG provide both phenotypic and evolutionary flexibility, and rapid evolutionary responses to selection have been documented in several species. The neuroendocrine and molecular cascades for behaviour provide many avenues for evolutionary change without requiring a change in peripheral hormone levels. Sexual differentiation has some potential to be a source of evolutionary inertia in birds and could contribute to the lack of diversity in certain reproductive (including life history) traits. It is unclear, however, whether that lack of diversity would impede adaptation to rapid environmental change given the role of behavioural flexibility in avian reproduction.

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Section: The Sexual Differentiation Cascadesmentioning

confidence: 99%

Do hormonal control systems produce evolutionary inertia?

Adkins‐Regan

2007

Phil. Trans. R. Soc. B

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“…these chemicals are known to interfere with endocrine functions, leading to reproductive and developmental anomalies in wildlife populations (Cooper and Kavlock 1997), which may cause malformations on sexual characters and disturb the reproductive function in fish (Harrison et al 1997;Tyler et al 1998;Mills and Chichester 2005;Goksoyr 2006) and other vertebrates (Colborn et al 1993;Guillette and Gunderson 2001;Halldin 2005;Ottinger et al 2005).…”

mentioning

confidence: 99%

Tilapia Larvae Aroclor 1254 Exposure: Effects on Gonads and Circulating Thyroid Hormones During Adulthood

Coimbra

Reis-Henriques

2007

Bull Environ Contam Toxicol

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Aroclor 1254 a polychlorinated biphenyls (PCBs) mixture, when administrated through the diet, was previously found to inhibit adult tilapia (Oreochromis niloticus) reproduction. Since fish larvae can be more sensitive to contaminants, the objectives of this study were to evaluate in adults the impact in gonad development and in thyroid function of Aroclor 1254 administrated at larvae stages. Aroclor 1254 exposed tilapia presented both ovary and testicular alterations and a decline in T4 plasma concentration while T3 remained unaltered. This work shows exposure to Aroclor 1254 during tilapia early life stages causes a disruption of the reproductive axis that enables reproduction.

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“…As such, egg injection studies mimic maternal deposition of chemicals, providing an opportunity to dose the embryo with known concentrations of compound and track effects throughout ontogeny. These studies have shown impacts of EDCs on reproductive and metabolic endocrine systems, behavior, and heart function, especially with exposure during embryonic development (Ottinger et al 2005;2009;Ottinger and Dean, 2011). Findings from comparison of existing studies reveal that many EDCs do impact avian species in support of observations of wild populations (Rattner et al, 2004).…”

Section: Validation Of the Mysid Two-generation Toxicity Test For Thementioning

confidence: 67%

Endocrine disruption: Where are we now: Tier 2 testing

Ottinger

Flynn

Degitz

et al. 2016

Preprint

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The focus of this session was on the proposed USEPA Endocrine Disruption Screening Program (EDSP) Tier 2 testing protocols. Tier 2 tests have been developed to evaluate the potential impacts of endocrine disrupting chemicals (EDCs) over the life cycle across organisms representing vertebrate and invertebrate classes. Key aspects of these Tier 2 testing protocols rely on selecting appropriate measurement end points to reveal differential sensitivity and adverse impacts across an organism's life stages. To this end, certain Tier 2 tests utilize a multigenerational protocol, which detect both short-and longterm effects. However, multigenerational testing protocols can be time consuming and costly. As such, other testing protocols have also been considered, including partial lifecycle and extended one-generation tests. Regardless of the specifics of the multigenerational protocol, it is critical to identify key measurement end points that are responsive, reliable, and repeatable indicators of exposure to endocrine disrupting chemicals; these measures should also provide information to enable initial assessments Presentations in this session considered the strengths and weaknesses of the Tier 2 assays across several classes of organisms, and provided an industry perspective on Tier 2 testing. The interactive panel discussion provided an interesting perspective that balanced regulatory needs for reliable testing protocols that are highly repeatable and utilize consistent indices of exposure and adverse effect.

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Consequences of endocrine disrupting chemicals on reproductive endocrine function in birds: Establishing reliable end points of exposure

Cited by 53 publications

References 38 publications

Do hormonal control systems produce evolutionary inertia?

Do hormonal control systems produce evolutionary inertia?

Tilapia Larvae Aroclor 1254 Exposure: Effects on Gonads and Circulating Thyroid Hormones During Adulthood

Endocrine disruption: Where are we now: Tier 2 testing

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