Consequences of live poliovirus vaccine administration in chronic fatigue syndrome

Vedhara, Kavita; Llewelyn, Meirion B.; Fox, Julie D.; Jones, Matthew D.; Jones, Rhys; Clements, G. B.; Wang, E. C. Y.; Smith, Andrew Paul; Borysiewicz, Leszek K.

doi:10.1016/s0165-5728(97)00032-5

Cited by 11 publications

(11 citation statements)

References 36 publications

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“…Several studies have been conducted intended to examine either the risk for CFS onset associated with vaccination or the effect of using vaccines in patients diagnosed as having CFS 43 . One study performed by Moraq et al .…”

Section: Vaccination and Cfsmentioning

confidence: 99%

“…Another study suggested that vaccination involving aluminum‐containing adjuvants could trigger the cascade of immunological events, which are associated with immune‐disrupting conditions, including CFS and macrophagic myofasciitis 51 . Concerning the effect of vaccination on patients having CFS, several studies have shown the safeness of vaccination use 52 . Noteworthy, polio virus vaccination was not found to be clinically contraindicated in CFS patients; however, there was evidence of minimally altered immune reactivity and virus clearance 52 .…”

Section: Vaccination and Cfsmentioning

confidence: 99%

“…Concerning the effect of vaccination on patients having CFS, several studies have shown the safeness of vaccination use 52 . Noteworthy, polio virus vaccination was not found to be clinically contraindicated in CFS patients; however, there was evidence of minimally altered immune reactivity and virus clearance 52 . By contrast, other researchers have shown that the effect of vaccination with a staphylococcus toxoid in patients with FM and CFS is somehow beneficial (Table 2).…”

Section: Vaccination and Cfsmentioning

confidence: 99%

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Infection, Vaccination, and Autoantibodies in Chronic Fatigue Syndrome, Cause or Coincidence?

Ortega-Hernandez

Shoenfeld

2009

Annals of the New York Academy of Sciences

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Chronic fatigue syndrome (CFS) is a heterogeneous syndrome of unknown etiology and physiopathology. CFS patients complain about disabling fatigue, depression, difficulty with memory, and concomitant skeletal and muscular pain. Interestingly enough, there is certain overlap between CFS symptoms, autoimmune rheumatic disease, and infectious diseases. Certain neuroendocrine-immune abnormalities have also been described, and autoantibodies commonly described in some autoimmune diseases have been found in CFS patients as well. An increasing number of autoantibodies, mainly directed against other nuclear cell components, have been illustrated. Likewise, an association between some infectious agents, antibody production, and later CFS onset has been reported. Similarly, vaccination is depicted as playing an important role in CFS onset. Recently, a case report pointed toward a causal association between silicone breast linkage, hepatitis B virus vaccination, and CFS onset in a previous healthy woman. Such findings suggest that there is a likely deregulation of the immune system influenced by specific agents (infections, vaccination, and products, such as silicone). Evidence suggests that CFS is a complex disease in which several risk factors might interact to cause its full expression. Thus, although different alterations have been found in CFS patients, undoubtedly the main feature is central nervous system involvement with immunological alterations. Therefore, a new term neuro-psycho-immunology must be quoted. New studies based on this concept are needed in order to investigate syndromes, such as CFS, in which immunological alterations are thought to be associated with concomitant psychological and health disturbances.

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Section: Vaccination and Cfsmentioning

confidence: 99%

Section: Vaccination and Cfsmentioning

confidence: 99%

Section: Vaccination and Cfsmentioning

confidence: 99%

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Infection, Vaccination, and Autoantibodies in Chronic Fatigue Syndrome, Cause or Coincidence?

Ortega-Hernandez

Shoenfeld

2009

Annals of the New York Academy of Sciences

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“…In addition, immunisation with various vaccines have been reported to trigger CFS. These vaccines include MMR, pneumovax, influenza, hepatitis B, tetanus, typhoid and poliovirus (Lloyd et al, 1988;Symmons et al, 1993;Gross et al, 1995;Grotto et al, 1998;Hyde, 1999;Report, 1993;Vedhara et al, 1997;Chia and Chia, 2003).…”

Section: Vaccinationmentioning

confidence: 99%

Chronic fatigue syndrome

Devanur

Kerr

2006

Journal of Clinical Virology

131

101

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“…This view is supported by several pieces of evidence. Perhaps the strongest evidence that CFS patients show abnormalities of their anti-viral mechanisms comes from a study involving polio vaccine challenge (Vedhara et al, 1997). CFS patients often report more negative life events, perceived stress, daily hassles and negative affect than healthy controls.…”

mentioning

confidence: 99%

Chronic fatigue syndrome and susceptibility to upper respiratory tract illness

Smith¹,

Thomas²,

Borysiewicz³

et al. 1999

British J Health Psychol

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Objectives. First, to determine whether chronic fatigue syndrome (CFS) patients report increased susceptibility to upper respiratory tract illnesses (URTIs) compared with healthy volunteers. Second, to determine whether symptom severity and use of medication is greater in CFS patients. Finally, to assess the impact of the URTIs on the subsequent clinical state of the patients. Design. A 10‐week diary study. Methods. The frequency and severity of URTIs were recorded over a 10‐week period by CFS patients (N = 62) and healthy controls (N = 44). The patients were selected according to the Oxford criteria and had previously been assessed at the Cardiff Chronic Fatigue Clinic. One group of patients and controls carried out the diary study from October to December, and another group from January to March. At the end of each of the 10‐week periods the volunteers completed standard questionnaires about the frequency and severity of symptoms of colds and influenza and their general clinical condition. Results. CFS patients reported more cold and influenza illnesses than the controls. The patients also reported greater symptom severity and use of medication for the URTIs; these differences were still observed when trait anxiety was covaried. There was little evidence of the URTIs leading to longer term changes in the primary symptoms of CFS. Conclusions. CFS patients report more URTIs, greater symptom severity and greater use of medication for these illnesses than healthy controls. Further studies are now necessary to determine whether these results reflect greater susceptibility to infection or differences in symptom reporting. The present findings also suggest that acute infections do not play a major role in the pathogenesis of CFS.

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Consequences of live poliovirus vaccine administration in chronic fatigue syndrome

Cited by 11 publications

References 36 publications

Infection, Vaccination, and Autoantibodies in Chronic Fatigue Syndrome, Cause or Coincidence?

Infection, Vaccination, and Autoantibodies in Chronic Fatigue Syndrome, Cause or Coincidence?

Chronic fatigue syndrome

Chronic fatigue syndrome and susceptibility to upper respiratory tract illness

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