Consequences of metformin intoxication.

Lalau, Jean–Daniel; Mourlhon, C; Bergeret, Agnès; Lacroix, Christian

doi:10.2337/diacare.21.11.2036

Cited by 59 publications

(50 citation statements)

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“…Metformin alone is not (7,8) or only rarely (1) associated with hypoglycemia (defined as symptoms and signs of hypoglycemia and/or plasma glucose levels Ͻ3.3 mmol/l and clinical response to glucose administration). According to a recent review (9), the reported risks of hypoglycemia for metformin users varied between 0 and 21%.…”

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confidence: 99%

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia

et al. 2008

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OBJECTIVE -Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral antidiabetes drugs. RESEARCH DESIGN AND METHODS-This study is a nested case-control analysis using the U.K.-based General Practice Research Database to identify patients with type 2 diabetes who used oral antidiabetes drugs. Within the study population, all incident cases of lactic acidosis and hypoglycemia were identified, and hypoglycemia case subjects were matched to up to four control patients based on age, sex, practice, and calendar time.RESULTS -Among the study population of 50,048 type 2 diabetic subjects, six cases of lactic acidosis during current use of oral antidiabetes drugs were identified, yielding a crude incidence rate of 3.3 cases per 100,000 person-years among metformin users and 4.8 cases per 100,000 person-years among users of sulfonylureas. Relevant comorbidities known as risk factors for lactic acidosis could be identified in all case subjects. A total of 2,025 case subjects with hypoglycemia and 7,278 matched control subjects were identified. Use of sulfonylureas was associated with a materially elevated risk of hypoglycemia. The adjusted odds ratio for current use of sulfonylureas was 2.79 (95% CI 2.23-3.50) compared with current metformin use.CONCLUSIONS -Lactic acidosis during current use of oral antidiabetes drugs was very rare and was associated with concurrent comorbidity. Hypoglycemic episodes were substantially more common among sulfonylurea users than among users of metformin.

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confidence: 99%

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia

et al. 2008

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“…It accumulates in the intestine, leading to an increased production of lactate, which lowers the pH within the liver and decreases lactate metabolism by suppressing pyruvate carboxylase. It also decreases glucose utilization and increases lactate production by the hepatocytes [11]. We did not find any reports of a direct link between metformin administration and rhabdomyolysis, but such a link has previously been reported with phenformin [12].…”

Section: Discussionmentioning

confidence: 43%

Acute rhabdomyolysis during treatment with amisulpride and metformin

Ursini

Succurro

Grembiale

et al. 2009

Eur J Clin Pharmacol

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“…Fenformin which belongs to the biguanides was recalled from market in USA in 1976. Lactic acidosis related to acute excessive metformin may be fatal (1). Here, a patient who was followed up with metformin intoxication has been presented.…”

Section: To the Editormentioning

confidence: 99%

Bir ergende metformin zehirlenmesi

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2012

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Consequences of metformin intoxication.

Cited by 59 publications

References 0 publications

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia

Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia

Acute rhabdomyolysis during treatment with amisulpride and metformin

Bir ergende metformin zehirlenmesi

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